Mal/TIRAP
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
... been described previously (15), and site-directed mutagenesis of this plasmid was performed to obtain HA-tagged MAL mutants using QuikChange II Mutagenesis Kit (Agilent Technologies). These plasmids were used for ...
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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
... lipopolysaccharide; Mal: MyD88-adaptor-like; MyD88: myeloid differ- entiation response factor 88; NF-κB: nuclear factor-κB; OR: odds ratio; PAMP: pathogen-associated molecular pattern; PBS: phosphate buffered ...
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Intrinsic and Extrinsic Regulation of Innate Immune Receptors
... TRIF, MAL/TIRAP, TRAM, IPS-1) which act as important messengers to activate downstream kinases (IKK complex, MAPKs, TBK1, RIP-1) and transcription factors (NF-κB, AP-1, IRF3), which produce effecter ...
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Role of polymorphisms of toll like receptor (TLR) 4, TLR9, toll interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
... the TIRAP/MAL Ser180Leu (rs8177374, assay code C__25983622_10) and the FCGR2A His131Arg non- synonyimous SNPs (rs1801274, assay code C___9077561_20) were then ...
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The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
... as TIRAP), TIR domain-containing adaptor- inducing IFN-  (TRIF), TRIF-related adaptor molecule (TRAM), and sterile ␣ and HEAT/armadillo (ARM) motif pro- tein (SARM) ...
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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling
... in TIRAP (Tirap 200L) were generated to provide an in vivo model of Mtb infection (Figure ...for Mal S200L, the Equivalent of Mal S180L, Develop More Severe Lung Inflammation in Response to In ...
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Genetic variation of TLR 4, TLR 9 and TIRAP genes in Iranian malaria patients
... protein TIRAP (Toll- interleukin-1 receptor domain-containing adaptor pro- tein), also known as MAL (MYD88 adaptor-like), mediates downstream signaling of TLR-2 and TLR-4 inducing pro-inflammatory responses ...
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Evaluation of Bioelement Levels in Rat Tissues in Organophosphate Insecticide (Malathion) Toxicity: Effects of Caffeic Acid Phenethyl Ester (CAPE)
... In this study, it is aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on bioelement levels of plasma, brain, kidney and liver tissues against malathion toxication in rats. The rats in Control group ...
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Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression
... TLRs, TIRAP and MyD88 have used protein overexpression systems, which induced ligand-independent activation of transcription factors such as NF-κB [6, 11, 19, ...and TIRAP caused ligand-independent ...
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Sex and the Single Mal Girl: How Voluntary Intoxication Affects Consent
... Thus far, I have argued for the plausibility that many cases of signifi- cantly intoxicated sex should be considered legal because of the likelihood that the partner made a pre-intoxicat[r] ...
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An Analysis of Glutathionylation in the Modulation of the Critical Innate Immune Regulators Mal and NEK7
... Previous investigations into the role of the deglutathionylating enzyme GSTO1-1 in macrophages have identified that GSTO1-1 is required for TLR4 signalling, as GSTO1-1- deficient J774.1A macrophages have decreased LPS ...
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Intracellular Maltose Is Sufficient To Induce MAL Gene Expression in Saccharomyces cerevisiae
... typical MAL locus is a cluster of three genes, all of which are required for maltose fermenta- ...the MAL-activator, a DNA-binding transcription activator of the MAL genes ...the MAL ...
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The Turkic and Mongol Lexical Units in Dairy Cattle Terms as Used in the Mongol Languages
... First of all, we should mention that the word mal (cattle), presented in the ancient Mongol language, dates back to the ancient Turkic word mal (property, fortune, wealth, goods) and is [r] ...
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Evaluation of Three Live Attenuated H2 Pandemic Influenza Vaccine Candidates in Mice and Ferrets
... H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses reemerge. H2 influenza viruses continue ...
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El mal en México: narco, demonios y mega exorcismos
... Las imágenes que representan al diablo resaltan no sólo porque materializa el mal, sino también porque exhiben un pene descomunal en erección. En un país como México con una violencia expansiva y mortal de género ...
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Maternal & Parinatal Outcome In Elderly Primi Gravida & Its Recent Effective ManagementVibha Moses, Vivek Yonati, Babita Ahirwal
... deliveries, mal-presentations, mal-positions, prolonged labor, increased caesarean section rate, induction of labor, pregnancy induced hypertension, diabetes mellitus, ante and post partum ...
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Tyrosine phosphorylation of MyD88 adapter like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
... of Mal alter Mal interactions with ...Y159A Mal variants compared to WT and Y196 Mal species ...untagged Mal proteins to immunoprecipitate overexpressed Mal ...Subsequently, ...
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THE EFFECTS OF THREE DIFFERENT MAL LOCI ON THE REGULATION OF MALTASE SYNTHESIS IN YEAST
... Our results confirm previous findings that strains carrying different M A L loci produce different levels of maltase (RUDERT and HALVORSON 1962) and demonstrate that th[r] ...
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Activation of Toll-Like Receptor 2 Prevents Suppression of T-Cell Interferon γ Production by Modulating p38/Extracellular Signal-Regulated Kinase Pathways following Alcohol and Burn Injury
... Previous studies have demonstrated that T cells can be activated by PAMPs, and that TLR2 recognizes the largest spectrum of PAMPs among the TLRs (18,43,44). TLR-mediated responses are controlled mainly by the ...
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Mal, more than a bridge to MyD88
... To date the only evidence of a Mal/non-‐TLR receptor association is with the receptor for advanced glycation end products (RAGE) [55]. Despite its name, RAGE is thought to respond not only to advanced glycation ...
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