mammalian orthoreovirus
Guanidine Hydrochloride Inhibits Mammalian Orthoreovirus Growth by Reversibly Blocking the Synthesis of Double-Stranded RNA
... Nonfusogenic mammalian orthoreovirus (MRV) is the pro- totype member of the family Reoviridae (40). Members of this family have genomes comprising 9 to 12 segments of double- stranded RNA (dsRNA), which are ...
13
Persistent mammalian orthoreovirus, coxsackievirus and adenovirus co infection in a child with a primary immunodeficiency detected by metagenomic sequencing: a case report
... of Mammalian orthoreovirus (MRV) infection in a child with a primary immunodeficiency ...with Mammalian orthoreovirus are very rare and probably of zoonotic ...
5
A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States
... porcine orthoreovirus is unique in morphology and biological ...porcine orthoreovirus induces syncytia in BHK-21 cells and dwarfing in developing chicken ...of mammalian orthoreovirus 3 1 ...
11
First identification of mammalian orthoreovirus type 3 in diarrheic pigs in Europe
... species Mammalian orthoreovirus (MRV) has been divided into three serotypes according to the capacity of type-specific antisera to neutralize virus infectivity and inhibit hemagglutination, with the ...
5
Detection of mammalian orthoreovirus type 3 (Reo 3) infections in mice based on serotype specific hemagglutination protein sigma 1
... anti-mammalian orthoreovirus type 3 serum (Lot: S1099); GE Healthcare (Fairfield, CT, USA): HisTrap™ HP (1 mL); Jackson ImmunoResearch Laboratories, ...
11
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1
... ABSTRACT Mammalian orthoreovirus (MRV) infection induces phosphorylation of translation initiation factor eIF2 ␣ , which promotes the formation of discrete cyto- plasmic inclusions, termed stress granules ...
23
Mammalian Orthoreovirus Particles Induce and Are Recruited into Stress Granules at Early Times Postinfection
... many mammalian orthoreovirus (MRV) strains results in shutoff of host, but not viral, protein synthesis via protein kinase R (PKR) activation and phosphorylation of translation initiation factor eIF2 ␣ ...
12
Characterization of a Replicating Mammalian Orthoreovirus with Tetracysteine-Tagged μNS for Live-Cell Visualization of Viral Factories
... ABSTRACT Within infected host cells, mammalian orthoreovirus (MRV) forms viral factories (VFs), which are sites of viral transcription, translation, assembly, and repli- cation. The MRV nonstructural ...
18
Mammalian Orthoreovirus Escape from Host Translational Shutoff Correlates with Stress Granule Disruption and Is Independent of eIF2α Phosphorylation and PKR
... nonfusogenic mammalian orthoreoviruses (MRV) are members of a large family of animal and plant viruses (Reo- viridae) that includes many members that are of considerable importance in human, animal, and plant ...
13
Localization of Mammalian Orthoreovirus Proteins to Cytoplasmic Factory-Like Structures via Nonoverlapping Regions of μNS
... We have previously shown that in addition to recruiting each of the viral core proteins and NS to VF, parental input core particles are recruited to FLS when cells transfected with a pl[r] ...
16
Virion Structure of Baboon Reovirus, a Fusogenic Orthoreovirus That Lacks an Adhesion Fiber
... MRV, Mammalian orthoreovirus; BRV, Baboon orthoreovirus; NBV, Nelson Bay orthoreovirus; ARV, Avian orthoreovirus; AqRVA, Aquareovirus A; AqRVC, Aquareovirus C; and AqRVG, Aquareovirus ...
13
Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes
... ments), mammalian orthoreovirus (MRV, ten), cyto- plasmic polyhedrosis virus (CPV, ten), and rotavirus (eleven) suggest that, among the Reoviridae , viral + RNAs undergo assortment to form ordered complexes ...
7
Structural Evolution of Reoviridae Revealed by Oryzavirus in Acquiring the Second Capsid Shell
... the Orthoreovirus core, and the Orthoreovirus ...for Orthoreovirus, Mammalian orthoreovirus subgroup 1, Lang strain (MRV-1; M24734), Jones strain (MRV-2; M31057), and Dearing strain ...
10
High Similarity of Novel Orthoreovirus Detected in a Child Hospitalized with Acute Gastroenteritis to Mammalian Orthoreoviruses Found in Bats in Europe
... with mammalian orthoreovirus (MRV) as the type species, were already recognized in the 1950s as respira- tory and enteric orphan viruses ...various mammalian hosts, including human and animal ...
8
Antimicrobial Peptides: Classification, action and therapeutic potential
... The fundamental differences between microbial and mammalian membranes is to protect mammalian cells against AMPs and enable selective action of these peptides (Yeaman and Y[r] ...
6
Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses
... Serology. Fresh blood from each bat was obtained using the Mi- crovette CB 300- l system (Sarstedt) and centrifuged for 5 min at 10,000 ⫻ g at 20°C for serum separation. All sera were stored at ⫺ 20°C for further use. ...
9
Unbiased Characterization of Anopheles Mosquito Blood Meals by Targeted High-Throughput Sequencing
... multiple mammalian hosts in a single blood ...the mammalian mitochondrial 16S ribosomal RNA genes (16S rRNA) should amplify more than 95% of the mammalian 16S rRNA sequences present in the NCBI ...
19
Identification of Mammalian Proteins That Collaborate with Type III Secretion System Function: Involvement of a Chemokine Receptor in Supporting Translocon Activity
... identify mammalian host proteins required for the cytotoxic effects associated with the Yer- sinia translocated substrate YopE, a GTPase-activating protein (GAP) that inactivates the small Rho ...
13
Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
... kinase mammalian target of rapamy- cin (mTOR) is a central regulator of immune responses, and drugs that inhibit the mTOR pathway have been shown to be antip- ...
17
Constitutive PtdIns(3,4,5)P3 synthesis promotes the development and survival of early mammalian embryos
... Mammalian preimplantation embryos develop in the oviduct as individual entities, and can develop and survive in vitro, in defined culture media lacking exogenous growth factors or serum. Therefore, early embryos ...
5