mammary carcinomas
Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status
... feline mammary tumor cells (FMCp, Figure 4A, lane 2), and cross-reacts with the recombinant human HER2-ECD (Figure 4A, lane 3, 84-90 ...negative mammary carcinomas (Figure 4B, lines 3 and 4) or ...
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Expression of matrix metalloproteinase 2 (MMP-2), E-cadherin and Ki-67 in metastatic and non-metastatic canine mammary carcinomas
... mammary carcinomas in women and found that MMP-2 plays an important part in the metastasis of those tumours to regional lymph nodes. In addition, the authors found a significantly higher MMP-2 expression in ...
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Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice
... of mammary carcinomas, whereas the Atm null allele exhibited ...enhanced mammary carcinoma development in p53-heterozygous deficient mice, but the effect of Atm defi- ciency was not as ...
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T-cell epitope strength in WAP-T mouse mammary carcinomas is an important determinant in PD1/PD-L1 immune checkpoint blockade therapy
... for mammary carcinomas, we compared the response to immune checkpoint blockade therapy in tumor mice expressing either SV40 T-antigen containing the LCMV NP-epitope (T-Ag NP in WAP-T NP mice), or the ...
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Immunoexpression of Cathepsin D and S100A4 Protein and Their Molecular Subtyptes in Canine Mammary Carcinomas
... canine mammary carcinomas ...luminal mammary cells was associated with an infil- trative tumor mode of growth, consequently leading us to conclude that S100A4 protein could be related to progression ...
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Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers
... of mammary cancer ...primary mammary carcinomas, we should be able to find such cells in the ...Primary mammary tumor cells from MMT mice were used as positive control in the left panels of ...
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Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform
... chemically-induced mammary carcinomas arising in rats injected with MNU; the tumours were highly heterogeneous and presented with a range of fibrosis levels as previously observed in this model and typical ...
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Snai 1 and Epithelial Mesenchymal Transition Related Protein Immunoexpression in Canine Mammary Carcinomas
... Epithelial-mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metasta- sis of various cancers in ...
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Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu induced retroviral rat model
... rat mammary carcinogenesis model, approximately 50% of mammary carcinomas in the intact model are hormonally responsive and can therefore be pre- vented by tamoxifen (2 mg/kg diet) ...of ...
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Spontaneous Mammary Carcinomas in Female Dogs: Association between Immunohistochemical Degrees of Neoplasia Aggressiveness and Residual Pyrethroids
... highest mammary neoplasias ...with mammary neoplasia, however was not investigate the influence of this insecticide in the genesis and aggressiveness of mammary ...of mammary carcinoma in ...
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Spontaneous Mammary Carcinomas in Female Dogs: Association between the Immunohistochemical Degree of Aggressiveness of Tumors, Intensity of DNA Damage and Residues of Pyrethroids
... Detection of DNA damage was performed using the Comet Assay performed on cells harvested by citopunc- ture of mammary tumors surgically excised (Groups I and II) and 11 fragments of biopsied breast of animals in ...
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Prolactin induced mouse mammary carcinomas model estrogen resistant luminal breast cancer
... Activity of the NRL-PRL promoter is not altered by estrogen [15], enabling us to examine the role of this steroid in the disease process. Proliferation of both mor- phologically normal MECs and preneoplastic epithelial ...
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STAT1 deficient mice spontaneously develop estrogen receptor α positive luminal mammary carcinomas
... The authors thank Drs. Paul Allen, Barry Sleckman, Emil Unanue, Ravi Uppaluri, Matthew Vesely (Washington University School of Medicine), Mark Smyth (Peter McCallum Cancer Centre), and Michel Aguet (Swiss Institute for ...
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Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
... ductal mammary carcinomas that are represented in vitro by MCF7 and HCC1419 cells derived from estrogen receptor–positive ductal carcinomas of the luminal subtype ...lobular mammary ...
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The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution
... of mammary cancers is indeed higher in women with fibrocystic mastopathy ...of mammary carcinomas (for review ...of mammary gland epithelia and connective tissue and which results in ...
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Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα positive breast carcinomas
... The relation of diet, especially fat intake, to recognized breast cancer prognostic indicators was investigated in humans as well in animal models. In rats, a high-fat diet significantly stim- ulated tumor proliferation ...
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Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα-positive breast carcinomas
... The relation of diet, especially fat intake, to recognized breast cancer prognostic indicators was investigated in humans as well in animal models. In rats, a high-fat diet significantly stim- ulated tumor proliferation ...
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Targeted activation of β catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
... breast carcinomas express phenotypic markers suggestive of a luminal origin, cDNA microarray analysis has revealed a distinct subclass of tumors that strongly express the genes encoding basal keratins, ECM ...
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The role and function of cadherins in the mammary gland
... the mammary gland, but in several breast cancer cell lines and during mammary carcinomas, cadherin-11 becomes expressed in the epithelial cells, suggesting an EMT has occurred ...the mammary ...
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Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis
... primary mammary carcinomas with normal breast tissues from the same sub- ...in carcinomas, but whole genome methylation profiling in primary mammary carcinoma indicates that the frequency of ...
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