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MAPK/ERK signaling pathway

Original Article Upregulation of CD147 promotes cell invasion, epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in colorectal cancer

Original Article Upregulation of CD147 promotes cell invasion, epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in colorectal cancer

... activated MAPK/ERK pathway, ERK inhibitor U0126 suppressed the CD147-induced cell invasion, migration and MMP-2, MMP-9 ...and MAPK/ERK signaling pathway is involved ...

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Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways

Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways

... associated signaling to regulate melaogenesis via manip- ulating a -MSH-induced ...and MAPK/ERK path- way [21] due to the decrease of tyrosinase gene expres- sion and melanin ...of MAPK/ ...

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FOXC2 Promotes Oxaliplatin Resistance by Inducing Epithelial-Mesenchymal Transition via MAPK/ERK Signaling in Colorectal Cancer

<p>FOXC2 Promotes Oxaliplatin Resistance by Inducing Epithelial-Mesenchymal Transition via MAPK/ERK Signaling in Colorectal Cancer</p>

... the MAPK/ERK pathway in ...assumed, MAPK/ERK signaling is activated in OXA- resistant HCT116/OXA cells, and inhibition of MAPK/ ERK can sensitize HCT116/OXA cells ...

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Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4

Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4

... the MAPK/ERK signaling pathway through downregulation of ...downstream MAPK/ERK signaling, thus, highlighting the potential of miR-98-5p as a therapeutic target for ...

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CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway

<p>CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway</p>

... several signaling pathways as well as the related proteins involved in cell proliferation regulation was ...MEK/ERK signaling pathway was regulated by the expression of CCNY in Hep2 ...The ...

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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway

Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway

... ticular tumor microenvironment, the autophagy performed a complex dual roles during the anti- cancer treatment [17, 18]. On the one hand, autophagy as a tumor suppressor, it can be a negative regulator of tumor formation ...

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Original Article Propranolol induces apoptosis in endothelial cells by inhibiting Akt and ERK phosphorylation and MAPK signaling pathway

Original Article Propranolol induces apoptosis in endothelial cells by inhibiting Akt and ERK phosphorylation and MAPK signaling pathway

... Propranolol may inhibit the phosphorylation of Akt and ERK through β-ADR pathway. Therefore, we treated ECs with high concentra- tions of epinephrine (100 μM) and propranolol (20 μM) to observe whether ...

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Decreased MALL expression negatively impacts colorectal cancer patient survival

Decreased MALL expression negatively impacts colorectal cancer patient survival

... the ERK signaling ...the ERK signaling ...the ERK MAPK signaling pathway and the MALL gene ...Ingenuity Pathway Analysis (IPA) software (http:// ...the ...

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Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway

<p>Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway</p>

... Human tissue microarrays were purchased from Shanghai Outdo Biotech, (catalog no. HCol-Ade180Sur-07, Shanghai, China). Demographic and clinicopathological data, including clinical stage (according to the American Joint ...

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Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

... many signaling cascades ...enhances ERK/MAPK signal ...and ERK phosphorylation ...of ERK/MAPK pathway (PD98059) decreased the MMP-2 mRNA and protein expression ...

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Original Article p38 regulates mRNA stability of cytokines stimulated by Zymosan A

Original Article p38 regulates mRNA stability of cytokines stimulated by Zymosan A

... the MAPK signaling ...of MAPK signaling pathways and blocking experiments in pMΦs treated with Zymosan A were identified by western blot, and the change in TTP, which is a type of RNA binding ...

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Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans

Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans

... the ERK MAPK pathway genes downstream of Ras showed clear sup- pression of activated Gq, we were surprised to find that partial loss-of-function mutations in Ras did not ...the ERK ...

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Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

... RAS signaling in AML blasts ...PI3K/AKT pathway, L-744832 targeting RAS, PD98059 targeting ERK/MAPK signaling and AG1296 targeting FLT3, the authors found that NF- κB DNA-binding ...

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Natural gypenosides: targeting cancer through different molecular pathways

<p>Natural gypenosides: targeting cancer through different molecular pathways</p>

... MAPK/ERK pathway, also known as the Ras-Raf-MEK- ERK pathway, possesses several cascades and is mostly deregulated in human ...The MAPK/ ERK pathway molecules are ...

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ERK1/2 and MEK1/2 Induced by Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Early during Infection of Target Cells Are Essential for Expression of Viral Genes and for Establishment of Infection

ERK1/2 and MEK1/2 Induced by Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Early during Infection of Target Cells Are Essential for Expression of Viral Genes and for Establishment of Infection

... for signaling molecules in KSHV infection of target ...induced ERK in viral and host gene ...Moderate ERK induction with soluble gB was seen only in ...

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MAPK/ERK Signaling in Regulation of Renal Differentiation Kristen Kurtzeborn 1,2,# , Hyuk Nam Kwon 1,2,# , and Satu Kuure 1,2,3,

MAPK/ERK Signaling in Regulation of Renal Differentiation Kristen Kurtzeborn 1,2,# , Hyuk Nam Kwon 1,2,# , and Satu Kuure 1,2,3,

... the MAPK pathway shows very dynamic activation patterns in the UB ...of MAPK activity as the tips are abnormally expanded and accompanied by short UB ...by MAPK activity as chemical MEK ...

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Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells

<p>Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells</p>

... of MAPK signaling pathways in the migra- tion and invasion of NSCLC cells and found that the levels of p-MEK and p-ERK were signi fi cantly increased after OPN overexpression, which were dramatically ...

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FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway

<p>FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway</p>

... Protein was extracted using RIPA lysis buffer (Beyotime Biotechnology, Shanghai, China) containing protease inhibitors (Roche, Guangzhou, China) and then quanti fi ed with BCA ™ Protein Assay Kit (Pierce, Appleton, WI, ...

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Crucial requirement of ERK/MAPK signaling in respiratory tract development

Crucial requirement of ERK/MAPK signaling in respiratory tract development

... via MAPK pathways throughout lung development, including members of the fibroblast growth factor (FGF) family, such as FGF1, -2, -7, -9, -10 and -18, the platelet-derived growth factor A (PDGFA) and the epidermal ...

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Requirement for Map2k1 (Mek1) in extra embryonic
ectoderm during placentogenesis

Requirement for Map2k1 (Mek1) in extra embryonic ectoderm during placentogenesis

... (MAPK) signaling pathways consist of protein kinase cascades linking extracellular stimuli with various targets scattered in the cytoplasm, the cytoskeleton, the cellular organelles and the nucleus (Seger ...

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