Mast cell-deficient mice
The Effects of PM2.5 on Allergic Inflammation in Mast Cell Deficient Mice
... BALB/cJ mice do not display enhanced eosinophil infiltration or AHR following CAPs exposures ...of mice, and examined particles concentrated from the Boston airshed, which could have contributed to the ...
211
Physiological and immunological responses to Culicoides sonorensis blood feeding: a murine model
... node cell populations and cytokine expression profiles clearly showed a Th-mediated cellular response ...multiple cell types including CD4 + lymphocytes and acti- vated mast ...activated mast ...
13
Mast cell dipeptidyl peptidase I mediates survival from sepsis
... that mast cell DPPI enhances the likelihood of death from sepsis in WT mice, notwithstanding the net protective role of mast cells suggested here and in prior studies in mast ...
8
Cetirizine a histamine H1 receptor antagonist improves viral myocarditis
... years, mast cells have been implicated in the pathogenesis of cardiovascular and atherosclerotic disor- ...that mast cells cause apoptosis of cardiac myocytes and proliferation of nonmyocytes in vitro ...
6
Adenosine and inosine increase cutaneous vasopermeability by activating A3 receptors on mast cells
... Using mice deficient in the A 3 adenosine receptor (A 3 AR), we show that increases in cutaneous vascular permeability observed after treatment with adenosine or its principal metabolite inosine are ...
8
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
... Mast cell degranulation is important in the pathogenesis of anaphylaxis and allergic ...induce mast cell degranulation, and this has been thought to contribute to the pathology and mortality ...
13
Augmentation of reverse arthus reaction by mast cells in mice
... role mast cells in immune complex-mediated injury in mouse ...in mast cell-deficient WBB6F1-W/Wv mice and their congenic controls ...WBB6F1-W/Wv mice the neutrophil influx was ...
7
Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis Correction of the diminished secretory response in genetically mast cell deficient W/Wv mice by bone marrow transplantation
... genetically mast cell-deficient WBB6F1-W/Wv (W/Wv) mice and congenic normal WBBGF1(-)+/+ (+/+) ...+/+ mice, antigen caused increases in Isc which were significantly inhibited by ...
8
Galectin-3: its role in asthma and potential as an anti-inflammatory target
... 3+/+ mice developed significantly enhanced allergic airway inflammation and ...Gal-3+/+ mice, not only in the peribronchial inflammatory cells, but also in the fluid lining the airways as ...Gal-3+/+ ...
9
Involvement of chymase mediated angiotensin II generation in blood pressure regulation
... in mast cell–deficient (Kit w /Kit w-v ) mice and their mast cell–sufficient littermate (MC +/+ ) controls revealed that, in contrast to the latter, Kit w /Kit w-v mice ...
10
Macrophage inflammatory protein–1α as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions
... in mice deficient in macrophage inflammatory protein–1α (MIP-1α) despite normal numbers of tissue mast cells and no decrease in the levels of allergen- specific ...of mast cells in situ was ...
10
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis
... Mast cell–derived IL-4 controls phagocytosis by peritoneal macro- ...phagocytosis. Mast cells can rapidly release a number of cytokines upon ...of mast cell–derived IL-4 in the ...
14
Mast cell activation enhances airway responsiveness to methacholine in the mouse
... Mast cell-deficient mutant mice and their normal littermates were used to determine whether activation of mast cells by anti-IgE enhances airway responsiveness to bronchoactive agonists ...
8
Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype
... mutant mice were used: Lyn-/- mice ( Lyn -/- ) [44] and SHIP1-/- mice ( Inpp5d -/- ) ...these mice resulted in Lyn +/- Inpp5d +/- F1 progeny. F1 mice were mated to obtain wt, Lyn-/-, ...
16
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
... in mast cell function. First, we analysed whether cultured mast cells express RP105, which is indeed the case at both mRNA and protein level (Supplemental Figure ...in mast cell ...
13
Improved Simultaneous Estimation of Location and System Reliability via Shrinkage Ideas
... 3.3 Mast cells degranulation and S1P levels increase in OVA-treated skin tissues ...in mice deficient for SphK1 or mast cells: S1P-mediated skin mast cell degranulation and ...
138
Differences in the expression of the cardiopulmonary alterations associated with anti immunoglobulin E induced or active anaphylaxis in mast cell deficient and normal mice Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses
... genetically mast cell-deficient WBB6F1-W/Wv and congenic normal (+/+) ...W/Wv mice, and +/+ mice sensitized to develop high circulating levels of IgE exhibited HR, Cdyn, and GL ...
12
Mast cell hyperactivity underpins the development of oxygen induced retinopathy
... to mast cell degranu- lation, we measured β-hexosaminidase released from BMCMCs cultured in 75% oxygen for 5 days and then 20% oxygen for 12 hours in ...after mast cells were moved from hyperoxic to ...
15
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis
... potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis ...EG/EGE mice. ...
16
Mice that “conditionally” lack basophils, AT LAST
... However, using their mouse model of inducible basophil ablation, Wada et al. have provided indisputable evidence that it is indeed basophils that have a nonre- dundant role in Ab-mediated acquired immunity against ...
5