Matrix metalloproteinase 2/9
Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well ...
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Role of matrix metalloproteinase-2/9 (MMP2/9) in lead-induced changes in an in vitro blood-brain barrier model
... Previous studies have shown that the expression of MMP-2/9 affected tight junctions and basement membrane proteins [14]. To test whether Pb-induced the expression of MMP in C6 cells led to barrier-loss in ...
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Attenuation by fruit extract of (Amla) Emblica officinalis: Arsenic elevated concentration of serum matrix metalloproteinase 2 and 9 with high risk of cardiovascular diseases in mice
... The study was approved by the institutional animal ethics committee of King George’s Medical University, Lucknow (No. 121 IAH/Pharma-11), India, and all experiments were carried out in accordance with guidelines set by ...
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Identification of matrix metalloproteinase-2 and -9 activities within the intestinal mucosa of dogs with chronic enteropathies
... The association between an aberrant intestinal expres- sion of MMP-2 and -9 and human IBD is now well estab- lished [33]. MMP-2 and -9 have been investigated as biomarkers and diagnostic tool ...
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Effects of Diosgenin on Myometrial Matrix Metalloproteinase-2 and -9 Activity and Expression in Ovariectomized Rats
... Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and ...
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Circulating Matrix Metalloproteinase-2 and -9 Enzyme Activities in the Children with Ventricular Septal Defect
... maintain matrix homeostasis when present in the dynamic interstitial compart- ...of matrix remodeling and its reduction may promote a transition from compensated to end-stage congestive heart failure ...
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Activation and localization of matrix metalloproteinase 2 and 9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)
... Frozen skeletal muscles were homogenized in an extrac- tion buffer (62.5 mM Tris-HCl pH 6.8, 2% sodium dodecyl sulfate (SDS) 10% glycerol) and total protein content was assessed by the Bio-Rad DC Assay kit (Bio- ...
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Matrix metalloproteinase 2, 8 and 9 in serum and skin blister fluid in patients with severe sepsis
... Some medications used in sepsis, including vasopressor agents, hydrocortisone and activated protein C (APC), have been shown to affect MMP expression [29,31-33]. The elimination of these clinically central therapies from ...
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Aging is associated with increased activities of matrix metalloproteinase 2 and 9 in tenocytes
... tissue matrix components both in vivo and in vitro, to control the for- mation and degradation of connective tissues ...fibroblast matrix showed that the fibroblasts from aging rabbits produced ...
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Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
... tured in M-199 medium (Beit-Ha'Emek, Israel) contain- ing 10% Fetal Calf Serum (FCS, Beit-Ha'Emek, Israel) and penicillin/streptomycin (Beit-Ha'Emek, Israel). Cell cul- ture was maintained in a humidified atmosphere ...
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The Distribution of Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-4 in Psoriatic Skin
... Forty Psoriasis vulgaris patients between the age of 18 and 70 (31 men, 9 women) were selected. Patients had at least a six weeks history of characteristic psoriatic eruptions in typical localization sites. ...
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Active synovial matrix metalloproteinase 2 is associated with radiographic erosions in patients with early synovitis
... In the joint, MMP-9 is expressed in macrophages in the synovial lining layer, in vascular endothelial cells, leuko- cytes, chondrocytes, and osteoclasts. It is also expressed on cultured fibroblasts and on ...
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Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis
... Fig. 2 Effect of atorvastatin and amygdalin on matrix metalloproteinase-2 (MMP-2) and MMP-9 in the peritoneal fluid of Sprague-Dawley rats with experimentally induced ...
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Elevated matrix metalloproteinase 9 in patients with systemic sclerosis
... Detection of MMP-9 activities by gel zymography MMP-9 and MMP-2 activities were also tested by gelatin zymography. A 0.5-µl sample of serum diluted in 30 µl of SDS buffer was separated in 10% ...
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Matrix metalloproteinase 9 modulates collagen matrices and wound repair
... to 2-mm fragments) from the main body of fixed zebrafish embryos (so tail fins lay approximately flat) in a drop of PBS in a glass-bottomed imaging dish (Fluodishes, World Precision ...
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Original Article Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma
... of matrix metalloproteinase (MMP)-2 and tissue factor pathway inhibitor (TFPI)-2 not only correlate with tumorigenesis, but also with tumor invasion and ...
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Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways
... Cells lysates were prepared as described previously [27,28,35]. Equal amounts of protein were determined by the bicinchoninic acid protein assay (Pierce, Rock- ford, IL, USA). Samples were added to 5× Laemmli sam- ple ...
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Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
... Central sensitization refers to the process through which a state of hyperexcitability is established in the central ner- vous system, leading to enhanced processing of nocicep- tive (pain) messages. Although numerous ...
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Original Article Immunohistochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma
... Gleason’s grades in tumors were histologically evaluated [17] and a correlation with the most pronounced anaplastic changes in the tumor cells biopsy in this patient was observed. Level of total prostate-specific antigen ...
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<p>MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma</p>
... extracellular matrix breakdown in breast ...nases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumor- ...al. Matrix metalloproteinase (MMPs) expression by ...
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