Mechanical allodynia
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1
... Activation of spinal microglia and astrocytes is emer- ging as key mechanism underlying chronic pain [15]. Activation of astrocytes has been shown to contribute to the development of chronic pain in various preclinical ...
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CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries
... Compared with sham-operated animals, αβTCR + cells with morphological features of T cells (lobular or U-shaped large nuclei) are obviously present de novo in the pia and arachnoid mater covering either the prox- imal L4 ...
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The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury
... surgery. Mechanical and heat sensitivity of the hind paw were then assessed once daily for one week ...the mechanical withdrawal threshold corresponding to robust mechanical allodynia occurred ...
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Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats
... It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory pain. The present study was designed ...
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Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation
... In conclusion, we have shown here that continuous intra- thecal administration of lamotrigine could prevent the devel- opment of L5/6 SNL-induced mechanical allodynia in rats by suppressing the activation ...
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Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes
... To examine the effects of intrathecal administrations of cef- triaxone on mechanical allodynia and hyperalgesia, separate groups of ZDF rats received intrathecal catheter implantation 1 week after arrival ...
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Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats
... In conclusion, our study demonstrates that DEX admin- istration 1 hour before reperfusion significantly suppresses the development of mechanical allodynia in a CPIP rat model in a dose-dependent manner. ...
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An evaluation of the analgesic effect of AnestaGel™ on mechanical allodynia in a rat model of postoperative incisional pain
... ischial tuberosity. All animals recovered from anesthesia and returned to their general housing area. Nociceptive testing was performed at 2, 6, 10, 24, 48, 72, 96, and 120 hours postinjection. Mechanical ...
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A feed forward spinal cord glycinergic neural circuit gates mechanical allodynia
... In 1965, Melzack and Wall proposed a well-known hypothesis, the gate theory of pain, which has been highly influential for nearly 50 years (1). However, the theory remains primarily a matter of conjecture, due to ...
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Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting
... on allodynia development by the von Frey fila- ment test (Figure ...induction, mechanical allodynia following TH was completely abolished, and the effect lasted for at least 2 weeks after we stopped ...
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The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats
... attenuated tibial nerve crush induced cold and mechanical allodynia. It is known that diclofenac, as other non-selective NSAIDS, is able to impair prostaglandin synthesis by inhibition of the cyclooxygenase ...
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<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>
... In summary, we have designed an ef fi cient antioxidant defense platform for ROS elimination in partial sciatic nerve transection-induced neuropathic pain by using MONPs as intelligent ROS scavengers. A series of impor- ...
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Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis
... determined mechanical allodynia (pain caused by stimuli that do not normally evoke pain [23]) and locomotive function of the hindlimbs by using the TreadScan ™ gait analysis system (CleverSys ...
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<p>Co-Administered Low Doses Of Ibuprofen And Dexamethasone Produce Synergistic Antinociceptive Effects On Neuropathic Mechanical Allodynia In Rats</p>
... neuropathic mechanical allodynia in the rats with inferior alveolar nerve ...inhibited mechanical allodynia before the pain had been ...on mechanical allodynia on POD 7 – 9, when ...
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Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
... mediated immunoreaction in PDN of type 2 diabetes. Previously, we reported that intrathecal SB203580 treat- ment reduced mechanical allodynia [17] and the upregulation of IENF densities in db/db mice [43]. ...
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Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn
... To examine the anti-allodynia effect of RvD1 on CP- induced neuropathic pain, we intrathecally injected RvD1 at 5 w after TNBS infusion and observed the behavioral consequences. Compared to the vehicle control ...
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Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines
... alleviate mechanical allodynia in CIBP by inhi- biting the MAPK signaling pathway and NF-kappa B acti- vation to inhibit the production of pro-inflammatory ...
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CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5
... Next, we examined whether inhibition of miR-186-5p could induce CXCL13-dependent pain hypersensitivity. We i.t. injected miR-186-5p inhibitor into naive mice daily for 3 days and checked pain behavior 6 hours after each ...
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Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models
... to mechanical and heat stimuli in contralateral ...The mechanical or thermal thresholds were measured before and 1 h after each dose ...alleviated mechanical allodynia ...anical ...
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Immune cell–derived opioids protect against neuropathic pain in mice
... reversed mechanical allodynia measured at 30 minutes after CRF application, at early and later stages of neuropathy (P < ...change mechanical thresholds in paws ipsilateral (P > ...
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