Melanocortin receptor
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice
... MC4R: Melanocortin receptor 4; MPO: Myeloperoxidase; NeuN: Neuronal specific nuclear protein; p38 MAPK: p38 mitogen-activated protein kinase; PBS: Phosphate-buffered saline; RO: RO27-3225; ROS: Reactive ...
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Melanocortin Receptor 1 (MC1R) Mutations and Coat Color in Pigs
... The melanocortin receptor 1 (MC1R) plays a central role in regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis within the mammalian melanocyte and is encoded by the classical ...
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Identification of the minimal melanocyte-specific promoter in the melanocortin receptor 1 gene
... the melanocortin receptor 1 (MC1R), the pre- cursor of the α-melanocortin (α-MSH) and its seven- transmembrane G-protein coupled receptor, respectively ...
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Sweet Regulation of Melanocortin Receptor (MC1R, Mc3r, and MC4R) Transcription Activity
... Citation: Wen X, Zeng WW (2016) Sweet Regulation of Melanocortin Receptor (MC1R, Mc3r, and MC4R) Transcription Activity. Int J Endocrinol Metab Disord 2(1): doi http://dx.doi.org/10.16966/2380-548X.122 ...
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A +2138InsCAGACC Polymorphism of the Melanocortin Receptor 3 Gene is Associated in Human with Fat Level and Partitioning in Interaction with Body Corpulence
... genotype was similar to other genotypes, whereas in the obese subjects the 2138 insertion variant homozygotes showed less abdominal fat, particularly subcutaneous in contrast to visceral fat, than other genotypes. These ...
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Mouse models for the central melanocortin system
... nocortin receptor in the central nervous system that is antagonized by agouti and Agrp was enabled by a knock- out experiment in ...synthetic melanocortin receptor agonist melanotan II ...
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High Polymorphism at the Human Melanocortin 1 Receptor Locus
... The melanocortin 1 receptor (MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are known in many ...the melanocortin ...
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Candidate Gene Analysis for Quantitative Traits Using the Transmission Disequilibrium Test: The Example of the Melanocortin 4-Receptor in Pigs
... Population-wide associations between loci due to linkage disequilibrium can be used to map quantitative trait loci (QTL) with high resolution. However, spurious associations between markers and QTL can also arise as a ...
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Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling
... the melanocortin receptor family sig- nals by increasing levels of intracellular cAMP (42), which in turn leads to the phosphorylation of CREB, which activates transcription through the recruitment of the ...
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Role of leptin and melanocortin signaling in uremia associated cachexia
... The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-asso- ciated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 ...
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Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors
... Phenotypic leanness associated with high intrinsic aerobic capacity in rats is coupled with elevated total EE, and the predominant source of this is activity-related EE stemming from high daily physical activity along ...
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Energy Balance Effects of Central Melanocortin, Cocaine and Amphetamine Related Transcript and Leptin: Moving Outside of the Hypothalamic Box.
... endogenous melanocortin signaling in a given nucleus through the use of site-specific receptor antagonist or via viral knockdown of a given melanocortin ...
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Melanocortin 4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
... of receptor by the different pools of stably transformed cells was assessed by Northern ...The melanocortin receptor activation assay was adapted from Lu et ...
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Feeding induced by cannabinoids is mediated independently of the melanocortin system
... [24,25], often with greater effects than in lean littermates. In rats, Verty et al. (2004) demonstrated that central THC (a CB1-R agonist) increased food intake and central a-MSH decreased food intake, but that ...
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The central melanocortin system directly controls peripheral lipid metabolism
... nervous melanocortin system (CNS-Mcr) in the control of adiposity through effects on nutrient partitioning and cellular lipid metabolism independent of nutrient ...of melanocortin receptors (Mcr) in rats ...
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Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
... the Melanocortin-1 receptor (MC1R) gene, SKin cancer and Phenotypic characteristics (M-SKIP) project, we describe the most important steps in planning and conducting a pooled-analysis of genetic ...
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Central melanocortin receptors regulate insulin action
... were given intracerebroventricularly (17). Indeed, here we show that hypothalamic melanocortinergic neurons exert a tonic modulatory effect not only on feeding behavior but also on fat distribution and insulin action. In ...
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Motivational valence is determined by striatal melanocortin 4 receptors
... MC4Rs in the ventral striatum are critical for aversion. MC4Rs are expressed on striatal neurons (26), including a population of D1R-expressing medium spiny neurons (MSNs) (14, 27). Using mice with reporter constructs ...
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Melanocortin peptides inhibit urate crystal induced activation of phagocytic cells
... Alpha-melanocyte-stimulating hormone (α-MSH) is an endog- enous tridecapeptide with multiple effects on host cells. The synthetic peptide inhibits inflammatory responses in experimental models of acute and chronic ...
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NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice
... the melanocortin family, a group of peptides derived from pro-opiomelanocortin (POMC) ...five melanocortin re- ceptors (termed Mc1r to Mc5r) [6]. Melanocortin-1 re- ceptor (Mc1r), a G protein-coupled ...
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