Metastasis suppressor gene
Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
... Gastric cancer is a prevalent tumor that is usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report that Glypican-3 (GPC3) is absent in invasive tumors and ...
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Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
... target gene expression, we used the MARCM method of clonal analysis, which results in GFP-expression in mutant cells, so as to ensure that lack of gene expression is not the result of cell death (Figure ...
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Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma
... in metastasis” (MIM) gene. Among the multiple MIM gene products including MIM-A, MIM-B and MIM-C, MIM-B is the longest and most abundant protein in the cell, which is representative of MIM protein ...
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Original Article L-22 enhances the invasiveness of endometrial stromal cells of adenomyosis in an autocrine manner
... Abstract: It has reported that interleukin-22 (IL-22) promotes the invasion of tumor cells. IL-22 in the endometriotic milieu stimulates the proliferation of human endometrial stromal cells (ESCs). The present study ...
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Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc
... of metastasis and not the directionality of the ...suppressed metastasis. Further, it was demonstrated that a gene-expression signature induced by ectopic expression of Ndn in this cell line was ...
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<p>MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1</p>
... Results: We found that miR-769 was signi fi cantly underexpressed in PDAC tissues and cell lines. The low miR-769 expression signi fi cantly correlated with the TNM stage and lymph node metastasis. Patients with ...
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Original Article Down regulation of miR-148a is related to enhanced pancreatic cancer pathogenesis through targeting GLUT1
... Abstract: Pancreatic cancer (PC) is an aggressive malignancy with one of the worst mortality rates in the world. Multiple factors, including a complex and poorly understood pathophysiology and difficulty in early ...
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Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies
... In recent years, many studies on breast cancer and MDSCs have been performed. Breast cancer cells can recruit tumor-infiltrating leukocytes, including regulatory T cells (Treg), MDSCs and type 2 macrophages, to form a ...
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Cellular Reproduction
... When tumor suppressor genes don't work properly, cells can grow out of control. – More than 50% of tumors contain a mutation in the tumor suppressor gene p53..[r] ...
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Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer
... Many gene expression profiling analysis and aberrant methylation analysis were introduced for differentially expressed genes (DEGs) and differentially methylated genes (DMGs) ...both gene expression ...
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IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the Ras-Rac1 pathway
... In the present study, the potential role of IRF1 was inves- tigated in CRC cell lines through gain- and loss-of-function assays. The results demonstrated that IRF1 overexpression inhibited cell proliferation and ...
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Theodoropoulou, Marily (2002): Study on transcription factors involved in the pathogenesis of pituitary adenomas. Dissertation, LMU München: Fakultät für Biologie
... Zac1 gene expression in vitro, and this effect is pertussis toxin sensitive and is involving ...ZAC gene expression will facilitate the development of new pharmaceutical approaches which can target the ...
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Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid Associated Ophthalmopathy
... Sequencing of genomic DNA samples from 50 TAO patients revealed six genetic variants in the promoter region of ST3GAL5 and one nonsynonymous variant. In the case of ST8SIA1, three promoter variants were identified, while ...
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The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia
... p53 gene at codons 49, 53, 60, 140, 202, 204, 238, and 239 were observed in blast crisis ...N-RAS gene were rare in typical blast crisis (2 of 27 cases) but were found in megakaryocytic and Ph1 negative ...
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Identification of 42 genes linked to stage II colorectal cancer metastatic relapse
... for SEMG1, SMU1 and ING1. SMU1 and ING1 regulate genomic integrity and cell growth and their function could be altered by aberrant expression or gene structural changes that resulted in their association with MSS ...
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Tumor induced myeloid deviation: when myeloid derived suppressor cells meet tumor associated macrophages
... It appears that, while the expansion of MDSCs is often asso- ciated with poor prognosis, expansion of TAMs is not always a negative prognostic factor. When TAM evaluation is carried out at the molecular level, another ...
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Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.
... FIGURE 7. The fused phenotype is severely increased. LV4 is almost completely deleted and LV3 is thickened. genes involved in a given pathway. At the outset of this stud[r] ...
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Follistatin is a metastasis suppressor in a mouse model of HER2 positive breast cancer
... true metastasis suppressors ...core metastasis-associated expression signature of multiple cancers is INHBA , which encodes an activin and inhibin subunit ...
10
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
... identifies metastasis and invasion downstream genes of ...in metastasis and tumor invasion in AGS cells transfected with miR-335 mimic or with miR-335 ...
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Relationship between EGFR gene mutation and local metastasis of resectable lung adenocarcinoma
... Sole TNM staging is unable to predict early lung adenocarcinoma invasion, unlikely to identify recurrence in patients after surgical resection [19, 20], and unable to predict chemotherapeutic efficacy. The relationship ...
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