metastatic liver colorectal cancer (CRLM)
Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer
... of colorectal cancer (CRC) patients are diagnosed with metastatic CR ...of metastatic CRC is the liver, accounting for 30–40% of metastatic CRC cases, and the most common cause ...
10
Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors
... with liver-limited disease that was (1) ideally detected metachronously after a previous potentially cura- tive resection of the primary tumor; (2) confined to only one lobe of the liver; (3) showed no more ...
19
A single-institution experience with bevacizumab in the treatment of metastatic colorectal cancer and in conjunction with liver resection
... of liver function showed that, 3 months after resection, livers had regenerated as anticipated with enzyme levels and synthesizing capacity returned to the baseline ...
8
Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
... in metastatic SLN(s) and clinicopathological charac- teristics, no previous report was ...in metastatic SLN(s) is asso- ciated with age, type of tumor, tumor cell differentiation, tumor invasion depth, ...
8
Treatment of colorectal liver metastases
... the cancer cells, with a very acceptable toxicity ...of metastatic CRC ...in metastatic setting showed that adding cetuximab to FOLFIRI or FOLFOX, improved outcomes (ORR and PFS) in patients with ...
12
Synchronous and metachronous liver metastases in patients with colorectal cancer—towards a clinically relevant definition
... whom liver metastases were detected, the elec- tronic patient records of all included in the study were reviewed for at least 5 years after time of diagnosis of the primary tumour, or until time of ...of ...
10
Mutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapy
... We investigated DNA of primary (P) and corresponding meta- static (M) samples from 12 RAS and BRAF wild-type patients (five men and seven women) with a median age of 61 years (Table 1). Eight patients were nonresponsive ...
9
Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy
... to colorectal cancer, a recent miRNA array analysis reported that miR-885-5p is significantly up-regulated in liver metastases compared with that in primary colorectal cancer tissue, ...
12
Critical appraisal of bevacizumab in the treatment of metastatic colorectal cancer
... with colorectal liver metastases, because it correlates with statistically significant overall and disease-free survival of patients in this ...setting. Liver surgery is usually feasible after ...
13
Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF
... The liver metastasis model was based on orthotopic CRC model established previously with ...of liver were isolated. Then, Metastatic tumor fragments were minced into 1-mm cubes and digested in ...
12
Enumeration and targeted analysis of KRAS BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer
... of metastatic CRC [55, 56], as it has been demonstrated that a significantly higher number of CTCs can be isolated from mesenteric blood of colorectal cancer patients compared to peripheral blood, ...
16
Clinical and molecular determinants of extrahepatic disease progression in patients with metastatic colorectal cancer with liver-limited metastases deemed initially unresectable
... one liver-directed procedure, the smaller sample size prevented to derive robust conclusions on ePD determinants, though high- lighting the positive impact of subsequent liver re-treat- ments on the ...
9
Hepatic artery infusion therapy is effective for chemotherapy resistant liver metastatic colorectal cancer
... Colorectal cancer is highly prevalent in Japan and Western countries, and the number of deaths resulting from malig- nant tumors is substantial ...recurrent colorectal cancer has been im- ...
6
<p>Prognostic Usefulness Of Advanced Lung Cancer Inflammation Index In Locally-Advanced Pancreatic Carcinoma Patients Treated With Radical Chemoradiotherapy</p>
... versus 10.97 months; P<0.001). Similarly, Jank et al 27 reported that ALI>37.6 was signi fi cantly associated with superior 5-year disease-free survival (83.5% versus 47.0; P<0.001) and OS (73.6% versus 44.4; ...
9
Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy
... In cancer, VEGFR-1 appears to play a role in the epithelial-to-mesenchymal transition ...breast cancer [41] and it inhibited tumor growth in a mouse pancreatic neuroendocrine tumor model ...ian, ...
9
A Single Institutional Experience with Panitumumab in Metastatic Colorectal Cancer
... This study was a single-institution retrospective analysis of patients diagnosed with mCRC who were treated with panitumumab. The study was approved by The Ohio State University Internal Review Board. The study in- ...
8
DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer
... on cancer cell motility and invasive ...colon cancer cell lines (Figure ...colon cancer cell lines with their invasion and migration ...colon cancer metastasis, DDX3 level was suppressed using ...
11
The relationship between comorbidity medication adherence and health related quality of life among patients with cancer
... with cancer, and lack of adherence can compound health issues resulting in worsening of overall health ...breast cancer, as compared to a matched cohort of women without breast cancer; however, these ...
12
Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
... Our study has several limitations. It is retrospective, and the sample size of patients is small. The study was conducted over a decade; MSI tests were not homogenous, as they were performed over the years in different ...
8
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
... a colorectal cancer (CRC) patient presenting with synchronous lung metastasis and metachronous thyroid, chest wall and urinary tract metastases over the course of 5 ...and metastatic sites we ...
7