metastatic melanoma
CCN Proteins in Metastatic Melanoma
... malignant melanoma (Sha and Leask ...of melanoma, the majority of studies involving the role of CCN proteins in cancer have only correlated expression levels of the proteins with tumour progression without ...
169
Profile of ipilimumab and its role in the treatment of metastatic melanoma
... eradicate melanoma tumors in most ...attack melanoma have traditionally had marginal success, and served to remind us of the immense complexity of the balance between activating and inhibiting regulators of ...
7
The Pattern and Cost of Palliative Surgeries in Patients with Metastatic Melanoma
... tatic melanoma diagnosed between 2005 and 2011. Patient characteristics, patterns and cost of surgery, and length of hospital stay were evaluated. Results: Of the 2399 patients identified, 888 (37.0%) underwent at ...
6
Adoption of immunotherapy in the community for patients diagnosed with metastatic melanoma
... of melanoma patients with immunotherapy within 90 days of diagnosis increased from ...for metastatic melanoma has increased over time, adoption varies widely across ...
11
First-line treatment of metastatic melanoma: role of nivolumab
... advanced melanoma patients and has rightfully taken a center seat in the field of ...of metastatic melanoma treatment options by creating clinically relevant durable ...in melanoma and other ...
10
Ipilimumab in the treatment of metastatic melanoma: management of adverse events
... The most frequent GI side effect is diarrhea, characterized by watery/bloody stools, reported with a frequency of 20%–31% in the ipilimumab groups of the MDX010-20 Phase III trial, which led in 2011 to US Food and Drug ...
7
Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma
... highly metastatic melanoma [16], suggesting an involvement of Met in the phenotypic plasticity and heterogeneity of ...of melanoma cells are regulated by Met could promote an understanding of stage ...
15
Hospitalisation costs of metastatic melanoma in France; the MELISSA study (MELanoma In hoSpital coSts Assessment)
... The impact of the introduction of immunotherapies such as ipilimumab on the direct medical costs of management of metastatic melanoma would be expected to be two-fold. Firstly, since these agents reduce the ...
13
Trametinib: a MEK inhibitor for management of metastatic melanoma
... Last year, the results of a survey conducted during the METRIC study assessing quality of life for the first time during MEK inhibitor trials in metastatic melanoma patients were published. Quality of life ...
9
Enhanced IL-34 expression in Nivolumab-resistant metastatic melanoma
... malignant melanoma that acquired therapeutic resistance after several rounds of chemother- apy and Nivolumab-based immunotherapy, and compare the expression levels of IL-34 between primary or refrac- tory ...
5
Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors
... The clones segregated into three clusters, which we compared using gene set enrichment analysis (GSEA) (Table 1, full results in Additional file 7: Table S2). Inter- estingly, the clones with the expression profile most ...
13
Metastatic Melanoma of Unknown Primary: A Unique Entity? November 2012
... with melanoma of unknown a primary are based on these ...ocular melanoma; however, this was never ...for metastatic melanoma with unknown primary, but suggested a focused search based on ...
8
Pembrolizumab in Combination with Radiotherapy for Metastatic Melanoma - Introducing the PERM Trial.
... with metastatic melanoma unsuitable for combination immunotherapy and useful toxicity data to help trial design for other tumour sites, which may benefit from a similar treatment approach of radiotherapy ...
5
Medical Costs by Disease Stage in Medicare Patients with Metastatic Melanoma
... of melanoma patients, but rather a model with a number of assumptions, some of which have been questioned ...T3a melanoma were $35,407 (in 2008 US $) compared to $38,335 for stage T3b melanoma, ...
11
Drug targets and predictive biomarkers in the management of metastatic melanoma
... At present, vemurafenib is the only approved therapy that specifically targets an aberrant molecule in melanocytes. However the field is rapidly expanding, and many newer molecules are likely to be approved in the near ...
10
Spontaneous splenic rupture in patient with metastatic melanoma treated with vemurafenib
... IV melanoma [3]. In patients with metastatic melanoma featuring BRAF V600E muta- tion, phase 1 and 2 clinical trials of the BRAF kinase in- hibitor vemurafenib (PLX4032) have shown response rates of ...
5
Acute visual loss after ipilimumab treatment for metastatic melanoma
... with melanoma of the left forearm: nodular melanoma, Breslow thickness ...with metastatic melanoma (microscopic metastases with 2 foci <1 mm) and no additional involved lymph nodes on ...
7
Update on use of aldesleukin for treatment of high-risk metastatic melanoma
... Another treatment modality incorporating treatment with IL-2 involves the use of adoptive T-cell therapy (ACT). ACT using ex vivo-expanded T-cell clones or tumor-infiltrating lymphocytes (TILs) has been extensively ...
11
Original Article Increased expression of melanoma stem cell marker CD271 in metastatic melanoma to the brain
... Human melanoma contains multipotent stem cells that express the neural crest stem cell marker ...CD271-expressing melanoma cells in murine xenografts give rise to metastatic ...ous melanoma, ...
5
Current Choices and Strategies In the Treatment of Metastatic Melanoma
... Over the past 5 years, new treatment options for unresectable or metastatic melanoma have changed the field completely, resulting in improved OS for the first time. We are seeing long- term survivors in our ...
12