methionine–choline-deficient
Potential of 99mTc-MIBI SPECT imaging for evaluating non-alcoholic steatohepatitis induced by methionine-choline-deficient diet in mice
... Tc-MIBI scintigraphy is useful for discriminating NASH from simple steatosis in clinical studies [19]. These findings suggest the possibility of 99m Tc-MIBI imaging for the evaluation of hepatic mitochondrial function in ...
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Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis
... a methionine-choline-deficient (MCD) diet, the degree of liver damage is related to dietary sugar content, which drives de novo lipogenesis and promotes the hepatic accumulation of saturated fatty ...
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Gene Set Enrichment Analysis (GSEA) of Differentially Expressed Genes in Green Tea against Methionine-Choline Deficient Diet in High-Fat Patients in the Development of Non-Alcoholic Fatty Liver Disease (NAFLD)
... against methionine-choline deficient diet in high-fat patients in the development of non-alcoholic fatty liver ...a methionine-choline deficient ...
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Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy
... MCD: Methionine/ choline-deficient; MCS: Methionine/choline-supplement; NASH: Non- alcoholic steatohepatitis; NAFLD: Non-alcoholic fatty liver disease; NAS: NAFLD activity Score; ROS: ...
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Original Article Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice
... Abstract: Background: Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. Its histopathology and the effects of nutrition on liver ...
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Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities
... In the MCD diet fed animals there was no difference in any of the hepatic PI species (Fig. 5d and Additional file 1: Table S8B) decreased in both animal groups. 5f) only declined in WT1 [r] ...
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S100A4 Gene is Crucial for Methionine Choline Deficient Diet Induced Non Alcoholic Fatty Liver Disease in Mice
... Materials and Methods: S100A4 KO mice (n=20) and their wild-type (WT) counterparts (n=20) were randomly divided into KO/ MCD, Ko/methionine-choline-sufficient (MCS), WT/MCD, and WT/MCS groups. After 8 weeks ...
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Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH
... the methionine-choline deficient (MCD) diet rapidly produces the NASH phenotype of hepatic ste- atosis, inflammation, and fibrosis in mice within a short timeframe; however, it does not generate the ...
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AIMS In the present study, we evaluated whether RLX affects the development of liver fibrosis in
... AIMS In the present study, we evaluated whether RLX affects the development of liver fibrosis in an experimental mouse model of NASH in C57BL6 male mice fed with a methionine-choline deficient diet ...
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Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF
... The methionine-choline- deficient diet (MCD) is one of the most common tools inducing NAFLD in many studies ...the choline-deficient, L -amino acid de- fined, high-fat diet ...
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Supplementation of Rumen-protected Forms of Methionine, Betaine, and Choline to Early Lactation Holstein Cows
... of methionine, betaine, and choline to a Met-limited corn silage-based total mixed ration (TMR) on microbial metabolism by mixed ruminal ...protected methionine (0.09% of DM as methionine), ...
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Methionine and Choline Deficient Diet-induced Non-Alcoholic Steatohepatitis in Rats: Role of Melatonin
... as methionine and choline is a famous model for inducing NASH (Brunt, ...2005). Methionine and choline deficient (MCD) diet lacks two constituents, which are critical factors for ...
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Rat model of nonalcoholic steatohepatitis created by methionine and choline deficiency: biochemical and histological analyses
... Notes: Data are expressed as means ± standard deviation. in the McD group, serum levels of albumin, γ-glutamyltranspeptidase, alkaline phosphatase, and total bilirubin were increased compared with those in the control ...
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Dietary strategies to treat hyperhomocysteinaemia based on the biochemistry of homocysteine: a review
... after methionine loading is lower in black Africans than in Caucasians, which points towards a more effective Hcy ...that methionine handling capacity is ...
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Considering choline as methionine precursor, lipoproteins transporter, hepatic promoter and antioxidant agent in dairy cows
... 2004). Choline also works as an antioxi- dant in transition cows, it has antioxidant properties that protect cell and reduce the free radical production which damage liver cells (Elsawy et ...tected ...
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COMPARATIVE EFFECTS OF A PURIFIED AND AN ADEQUATE DIET ON THE COURSE OF FATTY CIRRHOSIS IN THE ALCOHOLIC
... Although fatty cirrhosis can be produced in animals by means of low protein diets and prevented by methionine or choline, Eckhardt and his coworkers 7, in a previous study from this labo[r] ...
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THE EFFECTS OF LIPOTROPIC FACTORS ON PHOSPHOLIPIDE TURNOVER IN THE PLASMA OF PATIENTS WITH CIRRHOSIS OF THE LIVER, AS INDICATED BY RADIOACTIVE PHOSPHORUS
... Group 2: Phospholipide turnover studied before and during treatment wcith a large "test dose" of methionine or choline Table 1I and Figure 2 Eight consecutive patients with portal cirrho[r] ...
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Modulatory effect of Kolin PlusTM, a polyherbal formulation on muscle growth development in choline deficient diet model of broilers: a genomic analysis using microarray
... with choline-deficient diet and choline-rich diet caused increased and decreased expression of CALB1 gene ...were deficient in choline, the upregulation of KLF15 has occurred to ...
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Metabolic Assessment of Gliomas Using 11C Methionine, [18F] Fluorodeoxyglucose, and 11C Choline Positron Emission Tomography
... tion was seen in only high-grade tumors.17,18 Using conventional modalities, there are no specific neuroradiologic features that can differentiate between ATs and oligodendroglial tumors[r] ...
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Decreased rates of methionine synthesis by methylene tetrahydrofolate reductase deficient fibroblasts and lymphoblasts
... Methionine synthesis from homocysteine was measured in intact human fibroblasts and lymphoblasts using a [14C]formate label. Seven fibroblast lines and two lymphoblast lines derived from patients with ...
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