MGMT Promoter Methylation
Clinically Relevant Imaging Features for MGMT Promoter Methylation in Multiple Glioblastoma Studies: A Systematic Review and Meta Analysis
... with MGMT promoter methylation, his- tology of underlying disease (WHO grade), mean age (range), and male/female ratio; 2) study characteristics: authors, publication year, institution, patient ...
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MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy
... CD133, a five-transmembrane cell surface protein found in human stem cells from various sources inclu- ding the central nervous system [44], has been proposed to detect GBM CSCs. Considering the inherent resist- ance of ...
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Relationship between Tumor Enhancement, Edema, IDH1 Mutational Status, MGMT Promoter Methylation, and Survival in Glioblastoma
... MGMT promoter methylation was found in 74/190 (39%) patients. MGMT promoter methylation status was associated with better survival (P ⬍ ....0004). Methylation status also ...
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Original Article Low APE1/Ref-1 expression significantly correlates with MGMT promoter methylation in patients with high-grade gliomas
... [17]. Methylation of the CpG island has been reported to be the essential mechanism for loss of MGMT func- tion ...showed MGMT promoter methylation [19]. The incidence of MGMT ...
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Original Article Prognosis value of MGMT promoter methylation for patients with lung cancer: a meta-analysis
... Nine of the studies identified met the inclusion criteria. They were published between 2003 and 2014, and 859 patients were included in the pooled analysis [16-24]. Table 1 lists the identified studies and their main ...
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Impact of MGMT Promoter Methylation as a Prognostic Marker in Patients with High Grade Glioma: A Single Center Observational Study
... Interestingly, the time to progression of patients in the control arm (radiothe- rapy alone) also appears to be more favourable in the patient whose tumors had MGMT promoter methylation suggesting ...
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MGMT promoter methylation in gliomas assessment by pyrosequencing and quantitative methylation specific PCR
... DNA methylation induced by TMZ is located at the O 6 -position of guanine and methylation in this position is considered to be the main contributor to the cytotoxic effect ...of MGMT is therefore ...
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Review Article MGMT promoter-enhancer single nucleotide polymorphism rs16906252 is associated with MGMT promoter methylation in cancer
... the small number of studies was short of suffi- cient statistical power to assess the correla- tions between MGMT rs16906252 polymor- phism and MGMT promoter methylation in can- cer. Further ...
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MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response
... of methylation standards (red=0 %, pink=25 %, blue=50 %, green=75 %, orange=100 %) and an unknown sample ...for MGMT promoter methylation ...known methylation level of the ...the ...
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MGMT promoter methylation and 1p/19q co deletion of surgically resected pulmonary carcinoid and large cell neuroendocrine carcinoma
... and methylation-specific polymerase chain reaction (MSP); MGMT promoter methylation was detected in 17 pa- tients ...of MGMT methylation than SCLC; however, the difference is not ...
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Original Article Detection of MGMT promoter methylation in glioblastoma using pyrosequencing
... for MGMT methylation detection is from 1:80 to 1:100, which is approximately five times less than MSP method ...tell methylation status of individual CpG island which may be more predictive to ...
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Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas
... The promoter methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT), encoding a DNA repair enzyme that confers re- sistance to alkylating drugs, has been by far the most inform- ...
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Original Article Heterogeneity of MGMT gene promoter methylation and protein expression in serial specimens in newly diagnosed glioblastoma
... of MGMT gene promoter methylation and its protein expression across different regions within the same ...of MGMT gene promoter methylation and protein ex- pression in different ...
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A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
... TERT promoter mutation with wild-type IDH tends to be associated with poor prognosis, although its use in predicting outcomes in GBM is controversial [1, 6, 13, 15, 26, ...the methylation status of the ...
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Probabilistic Radiographic Atlas of Glioblastoma Phenotypes
... between MGMT promoter methylation and time to progression, ADIFFI statistical analysis identified 2 distinct clusters (a and b in Fig 8D) in a similar location in all glio- blastomas; however, the ...
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... Glioblastoma is a significant medical problem of modern society because of its high mortality rate. Even with aggressive clinical care, long-term glioblastoma survivors comprise <15% of all cases. Further extensive ...
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<p>The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas</p>
... methylated MGMT and co-deletion may have been affected by the percentage of nor- mal (unmethylated) tissue present in the ...low MGMT methylation should be treated as methylated or unmethylated is ...
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Personalized treatment strategies in glioblastoma: <em>MGMT</em> promoter methylation status
... between MGMT promoter methylation (as being determined by both MSP and sequencing analysis) and MGMT mRNA expression ...mRNA MGMT expression was detected in approximately 25% of ...
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The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients’ survival: a meta analysis
... of MGMT protein causes impaired ability to repair DNA. Hyper-methylation of MGMT gene promoter might result in silencing gene expression and further down-regulate protein concentrations ...
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Original Article The prognostic value of O 6-methylguanine-DNA methyltransferase gene promoter methylation detected by gel-based methylation-specific polymerase chain reaction in patients with glioblastoma multiforme: a systematic review
... described MGMT promoter methylation [as determined by gel-based meth- ylation specific polymerase chain reaction (MS-PCR) analysis] as an independent favor- able prognostic factor in patients with ...
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