MGUS—Monoclona Gammopathy of Undetermined Significance
Altered mRNA Expression of Telomere-Associated Genes in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
... monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma ...with MGUS and 68 with MM, were ...analysis. MGUS patients showed increased TRF1 levels (P = ...
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Monoclonal Gammopathy of Undetermined Significance with Amyloid Deposition in the Lung and Non-Amyloid Eosinophilic Deposition in the Brain: A Case Report
... MGUS was diagnosed 9 months ago on serum pro- tein electrophoresis (SPEP) as patient was referred to our institution’s center for cancer and blood related diseases for hyperglobulinemia on routine blood work. At ...
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Altered Cortical Microarchitecture and Bone Metabolism in Patients with Monoclonal Gammopathy of Undetermined Significance
... Introduction Population-based studies have shown that fracture risk is increased in MGUS.1,2 Previously,3 we used high-resolution peripheral quantitative computed tomography HRpQCT imagi[r] ...
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Active multiple myeloma suppresses and typically eliminates coexisting MGUS
... monoclonal gammopathy of undetermined significance (MGUS) (Landgren et al, 2009; Weiss et al, 2009), are characterised by monoclonal plasma cells (PCs) in the bone marrow and monoclonal ...
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Original Article Gene expression profiling based on microarray among monoclonal gammopathy of undetermined significance, smoldering multiple myeloma and multiple myeloma
... Monoclonal gammopathy of undeter- mined significance (MGUS) and smoldering multiple myeloma (SMM), which are character- ized by no myeloma-related organ or tissue injury [4, ...premalignant ...
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Data quality of the monoclonal gammopathy of undetermined significance diagnosis in a hospital registry
... the MGUS diagnosis requires a concentration of the serum M-component of less than 30 g/L, percentage of monoclonal plasma cells in the bone marrow less than 10%, and no sign of organ or tissue impairment related ...
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Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study
... with MGUS has recently discovered 10 susceptibility loci with varying degree of significance (Thomsen et ...as MGUS would possibly be subject to ‘missing herit- ability’ which asserts, an association ...
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<p>Immunogenicity And Safety Of The 13-Valent Pneumococcal Conjugate Vaccine In Patients With Monoclonal Gammopathy Of Undetermined Significance – Relationship With Selected Immune And Clinical Parameters</p>
... blood collected to tubes with a clotting factor). 9 According to the studies published before, days 7 and 30 post-vaccination were chosen to monitor plasmablast levels and antibody titers. Detection of plasmablasts in ...
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Comparative Study of Immune Status to Infectious Agents in Elderly Patients with Multiple Myeloma, Waldenstrom's Macroglobulinemia, and Monoclonal Gammopathy of Undetermined Significance
... monoclonal gammopathy of undetermined significance ...and MGUS (n ⴝ 18) and in age-matched controls (n ⴝ ...and MGUS patients, and highest in the ...and MGUS, particularly ...
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Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study.
... and MGUS MABs in ...and MGUS MABS in ...Importantly MGUS response <25% was seen in 16/44 (36%) patients receiving a wide spectrum of therapies including intensive ...benign MGUS to MM) are ...
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Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report
... Monoclonal gammopathy of undetermined significance (MGUS) is a pre-malignant B-cell condition character- ized by the presence of a monoclonal protein and fewer than 10% clonal plasma cells in ...
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Increased activated regulatory T cell subsets and aging Treg-like cells in multiple myeloma and monoclonal gammopathy of undetermined significance: a case control study
... in MGUS, MM patients was sig‑ nificantly lower than that of controls (P = ...from MGUS to MM patients with normal controls (P = ...in MGUS and MM cohort compared with healthy controls (P < ...in ...
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Repurposing Dichloroacetate for the Treatment of Multiple Myeloma
... Multiple myeloma (MM) is an incurable B-cell malignancy with unsatisfactory conventional therapies, and new treatments are needed. MM presents with a glycolytic phenotype, which can be used as a potential target. About ...
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Early alterations in stem-like/marrow-resident T cells and innate and myeloid cells in preneoplastic gammopathy
... monoclonal gammopathy of undetermined significance (MGUS) ...(1). MGUS/MM is an attractive model to gain basic insights into early host response in human cancer because the precursor ...
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Smoldering multiple myeloma: prevalence and current evidence guiding treatment decisions
... monoclonal gammopathy of undetermined significance (MGUS), SMM has a much higher risk of progression to ...for MGUS patients, SMM patients need to be studied more intensively in order ...
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Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature
... known MGUS, our patient has never had any malig- nant disease and was never treated with chemotherapy or ...that MGUS, in addition to hematologic malignancies, may also be a risk factor in the development ...
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Prevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study
... Ghanaian study were older, with an age range of 50- 74 years while in this study, the age ranged 20-84 years with a mean of 45.68 ± 10.3 years. The prevalence of MGUS have been clearly reported to increase with ...
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Abnormal function of B lymphocytes from peripheral blood of multiple myeloma patients Lack of correlation between the number of cells potentially able to secrete immunoglobulin M and serum immunoglobulin M levels
... concentrations was seen in 42% of patients assessed at two or more time points. Of 44 patients, 52% showed a lack of correlation between the number of surface IgM+ (sIgM+) B cells and serum IgM concentration. One subset ...
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The untold stories of the speech gene, the FOXP2 cancer gene
... myelomas, MGUS (Monoclonal Gammopathy of Undetermined Significance), several subtypes of lymphomas [5,11], as well as in neuroblastomas [12] and ERG fusion-negative prostate cancers ...
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Role of erythropoietin in the angiogenic activity of bone marrow endothelial cells of MGUS and multiple myeloma patients
... monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) patients (MGECs and MMECs, respectively) and assessed whether Epo plays a role in MGECs- and MMECs-mediated ...
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