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microRNA-152-3p

Original Article MicroRNA-152-3p negatively regulates ischemia-reperfusion induced cardiomyocyte apoptosis by inhibiting PTEN

Original Article MicroRNA-152-3p negatively regulates ischemia-reperfusion induced cardiomyocyte apoptosis by inhibiting PTEN

... The PI3K/Akt signaling pathway is a classical protective pathway, and it has been involved in the maintenance of cell proliferation, apoptosis and inflammatory responses in most tissues [33, 34]. A study conducted by ...

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HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3p

<p>HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3p</p>

... Background: The aberrant expression of long non-coding RNAs (lncRNAs) plays a pivotal role in the development and progression of multiple cancers, including gastric cancer (GC). However, the underlying molecular ...

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Long non-coding RNA LINC00174 promotes glycolysis and tumor progression by regulating miR-152-3p/SLC2A1 axis in glioma

Long non-coding RNA LINC00174 promotes glycolysis and tumor progression by regulating miR-152-3p/SLC2A1 axis in glioma

... Long-chain non-coding RNA (lncRNA) is a kind of RNA with a length range of 200 nucleotides to 100,000 bases, which lacks an effective open reading framework and is transcribed by RNA polymerase II without protein coding ...

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The expression of microRNA 574 3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma

The expression of microRNA 574 3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma

... Man microRNA reverse transcription kit on the ABI Prism 7000 real-time PCR system, according to the manufacturer’s instructions (Applied ...Man microRNA assays for hsa-miR-574-3p (Assay ID 002349) ...

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Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer

Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer

... Epithelial to mesenchymal transition (EMT) involves loss of an epithelial phenotype and activation of a mesenchymal one. Enhanced expression of genes associated with a mesenchymal transition includes ZEB1/2, TWIST, and ...

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Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis

<p>Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis</p>

... Bioinformatic analyses were performed to search for potential miRNAs targeting E2F3. According to the two bioinformatics programs (Targetscan and Pictar), a miR- 152 binding sequence was predicted in the E2F3 3 ʹ ...

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Original Article MicroRNA-140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2

Original Article MicroRNA-140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2

... Migration and invasion abilities are two essen- tial respects for cancer cell metastasis includ- ing lung cancer. We found that miR-140-3p reduced the migratory rate of both lung cancer cell lines by about 50% ...

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Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

... Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs ...

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MicroRNA-155-3p promotes hepatocellular carcinoma formation by suppressing FBXW7 expression

MicroRNA-155-3p promotes hepatocellular carcinoma formation by suppressing FBXW7 expression

... To corroborate this assumption, we tested whether overexpression of miR-155-3P in BEL-7405 cells pro- motes cell growth and colony formation ability by using MTT and colony formation assay. Overexpression of ...

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MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1

MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1

... Methods: The expression of DDR1 on OSCC patients was determine by quantitative real-time PCR (qRT-PCR) and immunohistochemistry. Specific targeting by miRNAs was determined by software prediction, luciferase reporter ...

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MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

... The let-7 family miRNAs is a group of key regulators of differentiation processes in development; changes in let-7 expression could lead to dedifferentiation via EMT and tumor progression [57]. Let-7 down-regulation is ...

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microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells

microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells

... MicroRNAs (miRs) are small non-coding RNA molecules 18-25 nucleotides in length, which negatively regulate gene expression at the post-transcriptional level by binding to imperfect complementary sites in the 3 ’ -UTR ...

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Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells

<p>Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells</p>

... MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway. Ettinger DS, Akerley W, Borghaei H, et al[r] ...

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MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas

MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas

... The microRNA- mediated post-transcriptional regulation of gene expression is achieved through several mechanisms, including (1) site-specific cleavage; (2) enhanced mRNA degradation; and (3) translational ...

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MicroRNA-19b-3p suppresses gastric cancer development by negatively regulating neuropilin-1

MicroRNA-19b-3p suppresses gastric cancer development by negatively regulating neuropilin-1

... and progression is not clear. To our knowledge, this is the first report to demonstrate that miR-19b-3p negatively regulates NRP1 expression in GC. Rescue experiments validated that overexpression NRP1 partially ...

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MicroRNA-126-3p suppresses cell proliferation by targeting PIK3R2 in Kaposi’s sarcoma cells

MicroRNA-126-3p suppresses cell proliferation by targeting PIK3R2 in Kaposi’s sarcoma cells

... We chose to study PIK3R2, among hundreds of genes, because it is closely involved in cell migration, proliferation, and survival [29, 30]. Dual-luciferase reporter assays showed that the cotransfection of miR- ...

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Original Article MicroRNA-21-3p serves as a novel biomarker for diagnosis of laryngeal cancer

Original Article MicroRNA-21-3p serves as a novel biomarker for diagnosis of laryngeal cancer

... Total RNA was isolated from all serum samples with TRIzol (Invitrogen, Carlsbad, CA, USA), respectively. Then reverse transcriphase was conducted to synthesize the first chain of cDNA with TaqMan MicroRNA Reverse ...

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MicroRNA-96-3p promotes metastasis of papillary thyroid cancer through targeting SDHB

MicroRNA-96-3p promotes metastasis of papillary thyroid cancer through targeting SDHB

... MicroRNAs (MiRNAs) are small, non-protein-coding RNAs which can regulate the gene expression post-tran- scriptionally by binding to mRNA 3 ′ untranslated region (3 ′ UTR), leading to translational repression or mRNA ...

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Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells

Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells

... MicroRNAs (miRNAs/miRs) are small, non-coding RNAs that modulate gene expression such as mRNA deg- radation by binding to the 3 ′ -untranslated region [13]. miRNAs have been suggested as potential drug targets in various ...

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The expression of microRNA-324-3p as a tumor suppressor in nasopharyngeal carcinoma and its clinical significance

The expression of microRNA-324-3p as a tumor suppressor in nasopharyngeal carcinoma and its clinical significance

... Notes: (A) Luciferase results confirmed that miR-324-3p could directly regulate the expression of GLI3 gene. The luciferase activity in cells containing wild-type GLI3-3′-UTr was significantly inhibited, compared ...

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