Minor groove binding ligands
Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... involving minor groove binders and DNA processing enzymes demonstrate inhibition of the proteins, there are some reports of an increase in enzyme activity in the presence of minor groove ...
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The antibacterial drug MGB-BP3 : from discovery to clinical trial
... the minor groove of DNA and details of the configuration of binding were known from X-ray crystallography ...new minor groove binding ...the ligands so that binding ...
9
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... side-by-side binding of ligands with the DNA minor groove it has become possible to develop tailored approaches to drug ...of minor groove binders (MGBs) proceeded from the ...
13
Protein and drug interactions in the minor groove of DNA
... of ligands with an important architectural feature of DNA, its minor ...non-covalent binding agents (1–3) and, in particular, for designed polyamide-based sequence-specific molecules ...the ...
10
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... DNA minor groove carries with it the advantage that a comparison can be drawn between the assembled structure of AIK-18/51 in both free and DNA bound ...of binding. Global rearrangement of a dimer ...
37
Dinuclear polypyridyl ruthenium(II) complexes as stereoselective probes of nucleic acid secondary structures
... subsequent binding resulting in some degree of modulation of the gene ...Selectively binding a unique DNA sequence in the human genome would require an incredibly complex drug able to recognise a sequence ...
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Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition
... DNA binding drugs, at least in part, are directly linked to their relatively weak DNA sequence targeting ...of binding to particular DNA sequences ...DNA minor groove binders (to be referred ...
9
Shape selective recognition of the DNA minor groove by hairpin polyamides
... crescent-shaped ligands that bind predetermined DNA sequences with affinities and specificities rivaling naturally occurring ...of minor groove-binding polyamides as tools for genomic analysis ...
18
Interaction of DNA with groove binding ligands
... of minor groove binding it is interesting to discover what role the charge of the netropsin plays in determining its ...the minor groove by reducing its ...the minor ...
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Why antibacterial minor groove binders are a good thing
... MGB-BP-3 is a lipophilic molecule that is known to undergo self-association in aqueous solution. Self association of MGB-BP-3 and its relatives has been studied in detail by NMR spectroscopy (Parkinson et.al. Med. Chem. ...
21
Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives
... CT-DNA, minor hyperchrom- ism with no obvious red or blue shift was ob- ...Intercalation binding mode of small molecules into the DNA helix results in hypochromism and red ...intercalation binding ...
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Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... target minor grooves of duplex DNA in order to control specific gene expression implicated in a disease ...of minor groove bin- ders on DNA ...enhanced binding affinity towards DNA when ...
9
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... in binding to proteins, but rarely invoked in small-molecule-DNA ...ligand binding to the minor groove of target dsDNA ...the binding of H33258 28 to a preferred A- tract sequence, ...
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Molecular pharmacology of a series of nitrogen mustard containing-and AT- and GC- recognising minor groove binding agents related to distamycin
... D evelopm ent of the technique closely follow ed the in tro d u ctio n of the M axam and Gilbert chemical sequencing m ethodologies. The original study utilised DNase I as the cleaving agent and studied the b inding of ...
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Minor groove binders: some recent research in drug development
... the minor groove of DNA at regions with four or five AT base pairs, ...DNA binding molecules, one of which is the treatment of MRSA, hospital acquired infections caused by Staphylococcus aureus and ...
11
An evaluation of minor groove binders as anti-lung cancer therapeutics
... groove of the DNA where the drug interferes with the genetic transcription. These modifications result in variations in the product from crucial genes involved in cell-cycle replications and finally induce cell ...
11
Microarray and Genome-wide Sequencing Approaches to Characterizing DNA Binding Molecules
... vitro binding are required for increasing frataxin transcription, presumably because of the large number of potential polyamide-binding sites in the human genome and availability of these sites in the cell ...
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DNA Binding Polyamides in Biological Systems
... Minor -groove binding transcription factors, such as TBP Figure 1.3, LEF-l, and TAX, have been excellent targets for polyamide inhibition, resulting in inhibition of RNA polymerase II tr[r] ...
185
Constructing Empirical Likelihood Confidence Intervals for Medical Cost Data with Censored Observations
... RNA G-quadruplexes have been identified as markers for neurodegenerative diseases, such amyotrophic lateral sclerosis (ALS) and other types of dementia, associated with the C9orf72 gene. Healthy individuals were ...
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