minor groove recognition
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
... impact minor groove ...other minor groove binders such as Hoechst33258 in complex with A-tract dsDNA ...uences groove width but also reduces allosteric modulation in a DNA ...of ...
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ATP-Dependent Minor Groove Recognition of TA Base Pairs Is Required for Template Melting by the E1 Initiator Protein
... origin recognition complex has been identified as the factor that marks the replicator (2), an activity that can melt the DNA in preparation for replication has still not been ...
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Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... that minor groove recognition by small molecules can be enthalpically or entropically driven or both and that the ther- modynamic signature of MGBs is highly dependent on ligand structure and the ...
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Constructing Empirical Likelihood Confidence Intervals for Medical Cost Data with Censored Observations
... bp recognition by DB2120, molecular modeling studies were conducted with the A4GT4 sequence using experimentally derived ...DNA minor-groove shape and makes excellent van der Waals interactions with ...
218
Shape selective recognition of the DNA minor groove by hairpin polyamides
... of minor groove-binding polyamides as tools for genomic analysis and expansion of the minor groove recognition code by designing internal and N-terminal replacements for ...
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Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... DNA minor groove carries with it the advantage that a comparison can be drawn between the assembled structure of AIK-18/51 in both free and DNA bound ...DNA minor groove would be substantially ...
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Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... in minor groove binder-DNA interactions is the 'phasing' of the bond forming moieties of the ligand and the DNA (Lown, ...the minor groove of DNA (Goodsell & Dickerson, ...
227
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... A series of novel bis-benzothiazole derivaties with head-to head orientation were synthesised, and their anti- proliferative activities on U937, HL60 and HeLa cells were investigated. Most of these new compounds showed ...
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Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes
... and minor groove binders, which attach between the helical ...the minor groove binders, such as SYTO-13, have been less well studied despite being potentially less perturbative to the DNA ...
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Characterization and recognition of minor histocompatibility antigens
... FB recognition patterns as observed in figure 4, we quantified MiHA gene expression levels of 6 EBV-LCL and 4 FB by micro- array ...FB recognition (Figure 5A, right ...T-cell recognition bars (Figure ...
229
Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups
... this minor groove binder rather than any intrinsic property of the ...Nevertheless, minor groove binders with both nitroalkenyl (11a,c) and tri- fl uoroacetamido (14c) tail groups showed signi ...
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Four pyrrole derivatives used as building blocks in the synthesis of minor groove binders
... amido)-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide}, are inter- mediates used in the synthesis of modified DNA minor-groove binders. In all four compounds, the nitro groups lie in the plane of the ...
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C60 Fullerene Effects on Diphenyl N (trichloroacetyl) amidophosphate Interaction with DNA In Silico and Its Cytotoxic Activity Against Human Leukemic Cell Line In Vitro
... small groove of DNA helix), 1XRW (CCTCGTCC - intercalation of compound into a small groove of DNA helix), and 2M2C (GCGCATGCTACGCG - binding of compound with large and small grooves of DNA ...
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Triplex Forming Oligonucleotides – Tool for Gene Targeting
... the minor groove of DNA in a sequence-specific manner, and usually refer to polymers containing N-methylimida- zole and N-methylpyrrole amino ...the minor groove of DNA ...
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Racial Disparity in Social Spatiality: Usage of National Parks and Opera Attendance
... DNA minor groove, the ligand curvature has been considered as one of the important factors along with hydrogen-bonding and hydrophobic interactions ...the minor groove to yield full contact ...
193
Establishment of a minor groove binder probe based quantitative real time PCR to detect Borrelia burgdorferi sensu lato and differentiation of Borrelia spielmanii by osp A specific conventional PCR
... Background: Borrelia burgdorferi sensu lato (sl), the causative agent of Lyme borreliosis, is transmitted by ticks of the genus Ixodes as vector. For identification of Borrelia infections in ticks a TaqMan™ minor ...
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Ethyl 2 aminooxazole 5 carboxylate
... & Minor, 1997) and COLLECT (Hooft, 1988); cell re®nement: DENZO and COLLECT; data reduction: DENZO and COLLECT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to re®ne ...
7
A simplified duplex real time PCR incorporating TaqMan minor groove binder (MGB) probes and an exogenous internal positive control for the simultaneous detection of Mycoplasma gallisepticum and Mycoplasma synoviae cultures
... cause their small size enables binding in the minor groove of double-stranded DNA, thus stabilising the duplex, which results in high melting temperature (Tm) values (Kutyavin et al. 2000; Guo et al. 2009), ...
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Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
... SG2000 demonstrated a similar level of potent in vitro ac- tivity against a panel of canine tumour cell lines as has been previously demonstrated against human tumour cells. Cytotoxicity correlates with the formation and ...
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Chemical and photo-induced nuclease activity of a novel minor groove DNA binder Cu(II) complex
... a groove binder molecule DAPI was studied by fluor- escence spectroscopy in order to understand whether the complex is able to displace DAPI molecules from DNA minor groove or EB molecule from DNA ...
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