miRNA, cancer
MiRNA-based therapeutic intervention of cancer
... of cancer [18]. Diverse cellular mechanisms contribute to miRNA deregu- lation in cancer, and genetic changes [19], aberrant DNA methylation [20] and histone acetylation [21] have been at- tributed ...
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Review Article Research progress on miRNA, miRNA-regulated signaling pathways and breast cancer
... breast cancer cells, in order to deeply under- stand cytological characteristics of breast can- cer, scientifically evaluate clinical progresses in breast cancer, assess prognosis of the cancer and ...
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Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer
... candidate cancer miRNA biomarkers from cancer condi- tional miRNA regulatory networks, and then applied this pipeline for PCa study, as described in the Methods sec- ...PCa miRNA ...
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Seven protective miRNA signatures for prognosis of cervical cancer
... Cervical cancer is the second cause of cancer death in females in their 20s and 30s, but there were limited studies about its ...identify miRNA related to prognosis and study their ...cervical ...
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Clinical and pathological implications of miRNA in bladder cancer
... bladder cancer oncogenesis, as they also have been linked to clinical outcomes in urothelial ...single miRNA or a signature of multiple miRNAs may improve risk stratification of patients and may supplement ...
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Original Article Correlation between miRNA-196a2 and miRNA-499 polymorphisms and bladder cancer
... of miRNA can be found in several diseases including tumors [7] and cardiovascu- lar diseases ...and miRNA-499 rs3746444 polymorphism is a proven contributor to tumors ...bladder cancer among Chinese ...
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The role of protein inhibitor of activated STAT3 and miRNA-18a expressions in breast cancer
... breast cancer and paired samples of non-can- cerous tissue from the same resected breast were obtained from 25 patients undergoing surgery at the Medical Re- search Institute ...breast cancer were subjected ...
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Plasma Level of miRNA-7, miRNA-409 and miRNA-93 as Potential Biomarkers for Colorectal Cancer
... their cancer cell- specific alteration pattern (Aminisepehr et ...of miRNA-93 (hsa-miR-93-5p), miRNA-7 (hsa-miR-7-5p) and miRNA-409 (hsa- miR-409-5p) were evaluated in plasma of CRC patients ...
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miRNA-21 as a novel therapeutic target in lung cancer
... in cancer, since one miRNA in charge of a specific function or mechanism can simultaneously target several downstream ...lung cancer and other malig- ...efficient miRNA inhibition and which is ...
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RETRACTED ARTICLE: Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network
... of miRNA is involved in the initiation and progression of human cancer [4], and the studies on ovarian cancer are widely conducted in the past few ...of miRNA deregulation in human epithelial ...
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MicroRNA (miRNA) in cancer
... each miRNA: however, the false positive rates were re- ported to be high ...particular miRNA to a specific type of cancer is additionally complicated by the genetic di- versity of tumors, and in cell ...
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The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes
... on cancer risk with significant SNPs then investigated for putative miRNA-binding sites ...der cancer, we previously found an association for the DSB repair MRE11 rs2155209 3 # UTR SNP with increased ...
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Current status and implications of microRNAs in ovarian cancer diagnosis and therapy
... ovarian cancer diagnostics / prognostics Previous studies in ovarian carcinoma have shown that miRNAs can be used in its diagnosis as well as progno- ...The miRNA-200 family plays an important role in ...
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Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs
... of miRNA biogenesis ...and miRNA-330, and consequently up-regulation of Mmp3/Mmp10/Mmp13 particularly? We addressed this question by transfecting ...colon cancer cells with three different siRNAs ...
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MicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7
... SGC-7901 cells transfected with miR-21-5p mimics, inhibitors, and negative miRNA were grown for 24 h. The cells were centrifuged at 1,000 rpm for 5 min and washed with PBS. Then the cells were stained with Hoechst ...
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High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer
... lung cancer but also in many other types of cancer (reviewed in [20, 26, 46, ...antiapoptotic miRNA [48] that was strongly overexpressed in most types of ...
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miR-544a promotes the invasion of lung cancer cells by targeting cadherina 1 in vitro
... LightSwitch™ (Promega, Fitchburg, WI, USA) luciferase assay reagents are from Promega Corporation (Fitchburg, WI, USA). miRNA NC and miR-544a mimic combine with E-cadherin (CDH1) 3 ′ UTR or CDH1 mutated 3 ′ UTR ...
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Recent progress in microRNA-based delivery systems for the treatment of human disease
... Colorectal cancer; CXCL12: Chemokine (C-X-C motif) ligand-12; DOTAP: 1,2-dioleoyl-3-trimethylammonium-propane; DSDAP: 1,2-distearoyl-3- dimethylammonium-propane; DSPC: 1,2-distearoyl- ...
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Original Article Comparison of microRNA expression levels between primary and recurrent breast cancer: microRNA-133a, microRNA-191, and microRNA-204 can predict local recurrence of breast cancer
... PANArray miRNA expression pro- filing system (Panagene, Korea) according to the manufacturer’s ...breast cancer sample in more than 3 out of 5 patients are considered as candidate miRNAs for validation test ...
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Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation
... and cancer development [4-6]. Microarray-based miRNA profiling assays attracted more attention because they constitute the efficient meth- odology to screen in parallel for the expression of hun- dreds of ...
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