Mismatch repair protein
A Role for DNA Mismatch Repair Protein Msh2 in Error-Prone Double-Strand-Break Repair in Mammalian Chromosomes
... We examined error-prone nonhomologous end joining (NHEJ) in Msh2-deficient and wild-type Chinese hamster ovary cell lines. A DNA substrate containing a thymidine kinase (tk) gene fused to a neomycin- resistance (neo) ...
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Original Article Loss of DNA Mismatch Repair Protein hMSH6 in Ovarian Cancer is Histotype-Specific
... DNA mismatch repair genes may be involved in the development of a subset of human ovarian ...hMSH6 protein in different histotypes of ovarian carcinoma and the associations between loss of hMSH6 ...
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Original Article Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer
... Abstract: The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and ...
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Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans
... EspB protein is secreted by this system and is required for translocation of effector proteins into the host ...effector protein translocation and AE do not occur ...cell protein phosphorylation, ...
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Heterogenous mismatch-repair status in colorectal cancer
... MMR protein immunostainings are generally stable and rela- tively easy to interpret; though challenges and pitfalls have been reported with false positive as well as false negative interpretations ...MMR ...
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DNA damage repair in ovarian cancer: unlocking the heterogeneity
... The alternative, (also known as the back up or microho- mology mediated end joining) pathway is less well char- acterised than the classical pathway. As the name suggests, it has been found to be active when other ...
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HBV infection increases the risk of macular degeneration: the roles of HBx mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation
... HBx protein in retinal epithelial cells, ARPE19 cells were stably trans- fected with either a mock plasmid or HBx-containing ...HBx protein was sta- bly expressed in the HBx-transfected ARPE19 cells, after ...
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Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D)
... DNA mismatch repair genes: MLH1, MSH2, MSH6 and ...biallelic mismatch repair gene mutations causing a syndrome referred to as ‘ constitutional mismatch repair-de fi ciency ’ ...
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Mismatch repair-induced meiotic recombination requires the pms1 gene product.
... The pmsl-1 mutation reduces the frequency of mismatch repair-induced events: We wished to test the hypothesis that the repair of heteroduplex DNA containing closely [r] ...
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Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
... the mismatch repair [MMR] pathway predicted to be required to repair damage to single bases arising from errors in DNA replication) resulted in increased proliferation in a lung assay of ...
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Role of Repair Enzymes - Damage Control of DNA From Ageing pans
... Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA. It plays a prominent role in faithfully duplicating the genome by ...
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An Escherichia coli Effector Protein Promotes Host Mutation via Depletion of DNA Mismatch Repair Proteins
... by protein heterodimers, termed the MutS and MutL com- ...abundant mismatch binding factor, while MutS  is composed of MSH2 and ...tual repair by DNA polymerase ␦ (reviewed in reference ...either ...
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Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
... DNA mismatch repair enzymes and is usually dependent on four key genes: mutL homologue 1 (MLH1), postmeiotic segregation increased 2 (PMS2), mutS homologue 2 (MSH2), and mutS 6 ...single-base ...
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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... Figure 2.—dP-induced mutant frequencies in wild-type and mismatch-repair-defective mutL strains and in wild-type strains carrying the MutL- overproducing plasmid pMQ350. (A) F⬘CC102 (䊊) and F⬘CC102 mutL ...
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Mismatch Repair Incompatibilities in Diverse Yeast Populations
... We developed a model to explain how a genetic incom- patibility involving the DNA mismatch repair genes MLH1 and PMS1 could arise in yeast (Figure 1; Heck et al. 2006; Demogines et al. 2008b; Bui et al. ...
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Maternal Effect for DNA Mismatch Repair in the Mouse
... number identified in mammals and the first to involve final concentration of 1 pmol/ml. The CA probe in hybridiza- a DNA repair gene. tion solution was stable when stored at 4⬚ and was used repeat- edly for a ...
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Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
... coli mis- match repair mutants, we found that mutations in yeast mismatch repair genes had no discernable effect upon either transcription-coupled repair or global nucleotide [r] ...
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Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime Avibactam Resistance in Pseudomonas aeruginosa Acute Infection
... To determine whether the apparent MutS defect results in an increase in the spontaneous mutation rate, we first used a rifampin reversion assay (51). We found the substitution frequency as measured by this assay to be ⬎ ...
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Conjugational Hyperrecombination Achieved by Derepressing the LexA Regulon, Altering the Properties of RecA Protein and Inactivating Mismatch Repair in Escherichia coli K-12
... the mismatch repair system, derepression of the LexA regu- lon, and specific alterations in RecA protein structure are involved in preventing recombination by one mech- anism, stimulating ...
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Advances in using PARP inhibitors to treat cancer
... excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), single strand annealing (SSA), homologous recombination (HR), and nonhomologous end joining (NHEJ) ...DNA ...
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