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mismatch repair system

Antagonism of Ultraviolet-Light Mutagenesis by the Methyl-Directed Mismatch-Repair System of Escherichia coli

Antagonism of Ultraviolet-Light Mutagenesis by the Methyl-Directed Mismatch-Repair System of Escherichia coli

... MutHLS mismatch-repair system can process UV-irradiated DNA in vivo and that the human MSH2·MSH6 mismatch-repair protein binds more strongly in vitro to photoproduct/base mismatches ...

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PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor

PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor

... Although direct sequencing of affected genes is defini- tive and identifies the specific mutation in a family, mutations involving exon skipping or located outside the amplified fragment may be missed on DNA-based ...

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Original Article Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women

Original Article Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women

... Table 2 reports the semiquantitative score of immunostaining (H-score) for the studied MMR system proteins. Bivariate analysis showed no significant differences between proliferative and secretory eutopic ...

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Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.

Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.

... Role of mismatch recognition proteins in hom- eologous recombination: From the data reported in this paper, we conclude that the mismatch recognition proteins MutS and [r] ...

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TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia

TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia

... DNA repair pathway found by this study have not been evaluated in ...DNA mismatch repair system mainly in favourable histology WT based on the pattern of protein expression of MLH1, PMS2, MSH2 ...

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Repair of single- and multiple-substitution mismatches during recombination in Streptococcus pneumoniae.

Repair of single- and multiple-substitution mismatches during recombination in Streptococcus pneumoniae.

... RADMAN, 1986 Structures of mismatched base pairs in DNA and their recognition by the Escherichia coli mismatch repair system. KNILL-JONES, 1981 DNA polymerase accura[r] ...

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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli

Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli

... DNA mismatch-repair system can protect cells against this mutagenic ...in mismatch-repair-defective mutH, mutL, and mutS strains than in a wild-type ...the mismatch-repair ...

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Conjugational Hyperrecombination Achieved by Derepressing the LexA Regulon, Altering the Properties of RecA Protein and Inactivating Mismatch Repair in Escherichia coli K-12

Conjugational Hyperrecombination Achieved by Derepressing the LexA Regulon, Altering the Properties of RecA Protein and Inactivating Mismatch Repair in Escherichia coli K-12

... the mismatch repair system, derepression of the LexA regu- lon, and specific alterations in RecA protein structure are involved in preventing recombination by one mech- anism, stimulating ...

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Maternal Effect for DNA Mismatch Repair in the Mouse

Maternal Effect for DNA Mismatch Repair in the Mouse

... number identified in mammals and the first to involve final concentration of 1 pmol/ml. The CA probe in hybridiza- a DNA repair gene. tion solution was stable when stored at 4⬚ and was used repeat- edly for a ...

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Mismatch Repair Incompatibilities in Diverse Yeast Populations

Mismatch Repair Incompatibilities in Diverse Yeast Populations

... ABSTRACT An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 ...

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Heterogenous mismatch-repair status in colorectal cancer

Heterogenous mismatch-repair status in colorectal cancer

... Extracted DNA was treated with bisulfite using the EZ DNA Methylation-Lightning™ Kit (Zymo Research, CA, USA) according to the manufacturer’s instructions. MLH1 promoter methylation status was analyzed by means of a ...

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HBV infection increases the risk of macular degeneration: the roles of HBx mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation

HBV infection increases the risk of macular degeneration: the roles of HBx mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation

... The National Health Research Institutes (NHRI) built a large database, the National Health Insurance Research Database (NHIRD), which includes the claims data from the Taiwan National Health Insurance (NHI) program. The ...

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Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans

Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans

... the mismatch repair [MMR] pathway predicted to be required to repair damage to single bases arising from errors in DNA replication) resulted in increased proliferation in a lung assay of ...

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Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D)

Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D)

... At presentation, about 30% of tumours have metastasised via cerebrospinal fl uid to other parts of the central nervous system. The diagnosis can be established using MRI and CT scanning. To evaluate whether the ...

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A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae

A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae

... strain. Repair in F-A strains is inef fi cient due to rejection of the heteroduplex intermediate created by annealing of the 3% divergent URA3 ...to repair by SSA (perhaps multiple times) but ultimately fail ...

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Characterisation of unusual DNA glycosylases from Trichomonas vaginalis

Characterisation of unusual DNA glycosylases from Trichomonas vaginalis

... DNA repair mechanism requires the recognition of DNA ends by the Ku heterodimer, made up of Ku70 and Ku80 proteins, which binds to the DSB (Davis and Chen, ...subsequently repair the ...

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The archaeal RecJ like proteins : nucleases and ex nucleases with diverse roles in replication and repair

The archaeal RecJ like proteins : nucleases and ex nucleases with diverse roles in replication and repair

... excision repair and mismatch repair, while in eukaryotes, the RecJ-like protein Cdc45 (which has lost its nuclease activity) is a key component of the CMG (Cdc45-MCM-GINS) complex, the replicative ...

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Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors

Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors

... Microsatellites are short tandem repeats of DNA bases scattered throughout the genome, and vary in size from tens to hundreds of bases. Micro- satellite regions are at particular risk of mutation such as the insertion or ...

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DNA damage repair in ovarian cancer: unlocking the heterogeneity

DNA damage repair in ovarian cancer: unlocking the heterogeneity

... damage repair (DDR) mechanisms as a stratification tool, has enormous ...to repair DNA damage is one of the hallmarks of the cancer cell, however rendering a cell defective in DNA damage repair is ...

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Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

... DNA repair systems (11–13, 16, 17, ...DNA repair defects may result in increases in mutational rates from 10-fold to greater than 1,000-fold, resulting in hypermutator phenotypes (27, 29, ...DNA ...

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