Mitochondria and cell death
Mitochondria: pharmacological manipulation of cell death
... for cell death in vivo (for critical commentaries see ...isolated mitochondria from these animals were defective in the PT response, except to extremely high concentrations of Ca 2+ , consistent with ...
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Mitochondria targeting and its consequences for cell death in neuroblastoma
... on mitochondria and its consequences on ...treatment; cell death at this early time point was only detected upon removal of glutamine and stimulation of oxidative ...avoid cell death ...
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Gentian extract induces caspase independent and mitochondria modulated cell death
... the cell death induced by the extract occurs caspase-independently and de- pends on metabolic status of mitochondrial respira- ...in mitochondria confer cells to have different suscepti- bilities to ...
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Mitochondria in energy limited states: mechanisms that blunt the signaling of cell death
... of mitochondria-based pathways for the signaling of apoptotic and necrotic cell death avoided under conditions of hypoxia, anoxia, diapause, estivation and anhydrobiosis? Functional trade-offs in ...
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Endoplasmic reticulum–mitochondria crosstalk in NIX mediated murine cell death
... blood cell formation and can cause heart failure by inducing cell death, but the requisite molecular events are poorly ...NIX-mediated cell death involving direct and ER/sarcoplasmic ...
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The mitochondria–endoplasmic reticulum contact sites: a signalling platform for cell death
... of cell death when constriction sites are stabilized ...in mitochondria during cell death, and there is convincing evidence demonstrating a contribution to BAX channel assembly ...
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Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells
... apoptotic cell death occurred by the intrinsic pathway, with release of cytochrome c in the cytosol, and activation of caspase-9 and ...inhibited cell growth in a concentration-dependent manner and ...
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PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling
... same cell, multiple functions, affecting pro- cesses such as gene transcription, hormone secretion, cell metabolism, cell contraction, cell survival and cell ...the mitochondria ...
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Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products
... their cell surface, we examined whether AGE affected mast cell ...mast cell death, as measured by annexin V/propidium iodide ...from mitochondria, and this release played a key role in ...
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Aluminum induces rapidly mitochondria-dependent programmed cell death in Al-sensitive peanut root tips
... sequence. Mitochondria swelling enhance mito- chondrial membrane permeability, result in the loss of inner membrane potential, enlarge mitochondrial per- meability transition pore, and release Cyt ...lead ...
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Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC
... tumor cell apoptosis, we found that HNSCC cell showed spatially increase of cyto-Ca 2+ and loss of ΔΨm was induced by DZNep ...the mitochondria [33]. In the absence of MICU1, mitochondria ...
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The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells
... lytic cell death in cancer cells, not only by directly attacking the plasma membrane, but also as a result of an injury to vital intracellular organelles, particularly mitochondria, after the ...
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Ovine herpesvirus 2 encodes a previously unrecognized protein, pOv8.25, that targets mitochondria and triggers apoptotic cell death
... various cell types, including bovine lymphocytes, the protein ...the mitochondria, followed by caspase-dependent apoptosis and ...the cell-death causing properties of ...of death and ...
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Coenzyme Q10 Protects Astrocytes from ROS-Induced Damage through Inhibition of Mitochondria-Mediated Cell Death Pathway
... decreased cell viability and this damaging effect was associated with superoxide accumulation, mitochondrial membrane potential hyperpolarization, mitochondrial respiration suppression, cyto-c release, and the ...
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HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death
... as cell growth and death 1 ...of cell growth and death are ...that mitochondria are one of the critical targets of lidocaine 2–4 ...from mitochondria play an essential role in ...
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A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells
... of mitochondria for their anti-cancer ...that mitochondria play a crucial role in B5G9- induced cell ...and cell death (Additional file 2: Figure ...cancer cell death by ...
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Sestrins regulate respiration and cell death through interaction with mitochondria
... endothelial cell func- tion but on the other hand increase the risk of hyperglycaemia due to impaired glucose uptake from the ...lial cell mitochondria, affect mitochondrial biogenesis and net- work ...
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Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death
... to mitochondria-driven apoptosis, which our group already in- vestigated in the past ...with mitochondria where it changes the metabolic phenotype of the cells promo- ting Warburg effect [50] and drives ...
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Co-involvement of the mitochondria and endoplasmic reticulum in cell death induced by the novel ertargeted protein HAP
... of cell apoptosis [6-7]. Various cell death stimuli including growth factor withdrawal, hormonal stimulation, and drug treatment [8] are known to alter the concentration of Ca 2+ in the cytosol, a ...
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Biochemical Changes in Mitochondria and its Role in Cell Death During Myocardial Ischemia-Reperfusion Injury.
... Although mitochondria maintain normal heart function by providing virtually all of the heart´s ATP, is also implicated in the development of ischemic ...of cell loss following myocardial ...heart. ...
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