mitochondria-mediated apoptosis
<p>JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells</p>
... into mitochondria and inhibi- tion of Bcl-2 mitochondrial translocation are two strategies to induce mitochondria-mediated ...induced apoptosis in PC-9, PC- 9/GR and H1975 cells, we ...
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Bufothionine induced the mitochondria-mediated apoptosis in H22 liver tumor and acute liver injury
... of apoptosis [23], disruption of the cell cycle [24], promotion of cell differentiation [25], and suppression of angiogenesis ...of apoptosis was a crit- ical step for ...the mitochondria- ...
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The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex
... cell apoptosis in A549 and NCI-H460 cells through extrinsic and intrinsic mitochondrial ...into mitochondria more faster, which lead to the decline of membrane potential and mitochondrial dysfunction, and ...
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Astaxanthin Prevents Atrophy in Slow Fiber Muscles by Inhibiting Mitochondrial Reactive Oxygen Species Via a Mitochondria-Mediated Apoptosis Pathway
... of mitochondria that have a lipid ...on mitochondria using Sol8 myotubes derived from the soleus ...a mitochondria- mediated apoptosis pathway and thus prevented muscle ...
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Induction of Mitochondria Mediated apoptosis in Ca ski human cervical cncer cells triggered by mollic acid arabinoside isolated from Leea indica
... to apoptosis and thus dictates the fate of life and death of a cell [35, ...in mitochondria-mediated apoptosis ...Since apoptosis is regulated by many genes, one possible explanation is ...
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Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway
... the mitochondria-mediated apoptosis pathway played an important role in VP16-induced ...the mitochondria induces the mitochondrial permeability transition, the event that releases cytochrome c ...
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Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species
... ABSTRACT Ent-kaurane diterpene compounds have attracted considerable attention in recent years due to its antitumor, antibacterial, and antiviral activities. However, the clinical development of natural kaurane ...
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The Mechanisms of Mitochondria-Mediated Apoptosis in Cancer Chemotherapy
... An imbalance between cellular production of ROS and the inability of cells to defend against them is called oxidative stress [32]. Multiple antioxidant defense mechanisms exist in a cell e.g. antioxidant enzymes ...
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Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B
... and apoptosis of hepatocytes. Genetic manipulation of the autophagy- mediated pathway indicated that autophagy might be a protagonist of apoptosis ...and apoptosis of hepatocytes in ...to ...
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Costunolide induces mitochondria mediated apoptosis in human gastric adenocarcinoma BGC 823 cells
... . Apoptosis of gastric tumor was detected by Tunel assay. Apoptosis related proteins (Bax, Bcl-2, cleaved caspase 9, cleaved caspase 3, β-actin is internal reference protein) of gastric tumor was detected ...
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<p>Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis</p>
... The xenograft assay in nude mice demonstrated DSG effectively inhibited the growth of CCA in vivo without obvious toxic and side effects. Down-regulated PCNA and Ki67 protein expression of DSG implied decreased prolif- ...
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Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis.
... AA but not in CA TN breast cancer cells. Interestingly, a decline in anti-apoptotic Bcl2 and depolarization of MMP was observed in AA breast cancer cells. In sharp contrast, Bcl2 levels remained steady or even increased ...
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Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells
... celastrol-induced apoptosis of HL-60 cells, the effects of celastrol on nuclear morphology, cell membrane permeability and mitochondrial membrane potential changes were evaluated using High Content Screening ...
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Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway
... to mitochondria, we assessed Bcl-2 family activation in METH-treated SH-SY5Y cells by immunoblot ...of mitochondria, which was observed as decreased membrane potential in METH-stimulated SH-SY5Y cells ...
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Anti-proliferation of MDA-MB-231 cells by Averrhoa bilimbi extract is associated with G0/G1 perturbation and mitochondria-mediated apoptosis independent of p53
... Practiced as folk medicine since ancient times, bilimbi (Averrhoa bilimbi) is commonly consumed and widely cultivated in Malaysia. In search for naturally occurring anticancer agents, a potential fruit extract was found ...
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Potent organometallic osmium compounds induce mitochondria mediated apoptosis and S phase cell cycle arrest in A549 non small cell lung cancer cells
... the mitochondria and inhibit thioredoxin reductase. 31 Targeting mitochondria in cancer cells appears to be a promis- ing strategy, since enhanced mitochondrial stability and resis- tance to ...
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Nanoparticle Delivery of Artesunate Enhances the Anti tumor Efficiency by Activating Mitochondria Mediated Cell Apoptosis
... and mitochondria matrix secretion, that makes a electropositive outside and negative inside transmembrane potential which can make a favoring delivery of ...in mitochondria could effectively trigger ...
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Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat
... dysfunctional mitochondria into cytosol and the activation of caspse-9, -3 and the cleavage of PARP indicated that mitochondria- mediated apoptosis was activated in hepatocytes by ...trigger ...
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Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water
... induced mitochondria-mediated apoptosis via increasing the expression level of proapoptotic protein, Bax, but decreasing the expression level of antiapoptotic protein, Bcl-2, resulting in an ...
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NS 398 induces caspase dependent, mitochondria mediated intrinsic apoptosis of hepatoma cells
... from mitochondria to cy- tosol in time-dependent manner following NS-398 treatment to hepatoma ...dependent, mitochondria-mediated intrinsic apop- tosis ...
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