Mitochondrial impairment
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
... intriguing. Mitochondrial dysfunction is a common theme in a wide group of neurodegenerative disorders in which axon degeneration is central, including Parkinson's disease (PD), Charcot-Marie-Tooth disease, ...
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Mitochondrial Impairment Induced by Sub-Chronic Exposure to Multi-Walled Carbon Nanotubes
... the mitochondrial compartment and the MWCN-induced ...of mitochondrial activity was detected by assessing the expression of PDK1 that regulates glucose metabolism by phosphorylation of the E1α subunit of ...
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Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
... Although α-syn deposits are primarily found in neurons in the PD brain, they also appear frequently in astrocytes [14–19]. Being the most numerous glial cell type in the CNS, astrocytes have great impact on the brain ...
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Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
... mechanisms are proposed to be involved in the regula- tion of cancer cell growth induced by Sodium butyrate including the inhibition of DNA double strand break re- pair and stress oxidative [9, 11]. It has been shown ...
11
Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach
... The partially nephrectomized (PNx) rat is a well- established model for investigation of archetypal patho- logical changes in CKD. Similar to human disease, the remnant kidney develops adaptive compensatory growth ...
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The Cuprizone-Induced Experimental Demyelination A Promising Animal Model for Multiple Sclerosis Type III-IV. Ph.D. Thesis. Péter Ács M.D.
... of mitochondrial respiratory chain and complex ...the mitochondrial impairment and consequent DNA damage is associated with poly(ADP-ribose) polymerase (PARP) overactivation contributing to OL cell ...
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The point mutations of mitochondrial tRNA threonine and proline in idiopathic repeated pregnancy loss
... Our data showed that the Mean±SD age of the women with RPL was 28.73±5.86 years and the mean±SD for the gestational age at the time of miscarriages was 10.35±3.75 weeks. These women had the history of 3 to 11 ...
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Company Registration No D
... recognised impairment losses may no longer exist or may have ...recognised impairment loss is reversed only if there has been a change in the estimates used to determine the asset’s recoverable amount since ...
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Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
... genetically inhibiting p47phox significantly attenuates this oxidative damage, mitochondrial dysfunction, pro- apoptotic changes, and dopaminergic impairment. We demonstrated that PKCδ is an oxidative ...
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SLOW, GO SLOW. population. system (3A4 and 2D6) à drug interactions (often theoretical). patients co-infected with hepatitis viruses.
... Minor Cognitive /Motor Disorder HIV Dementia marked cognitive impairment with marked functional impairment cognitive impairment with mild functional impairment Neuropsyc[r] ...
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Mitochondrial disorders: aetiologies, models systems, and candidate therapies
... for mitochondrial dysfunction involves delivery of polycistronic RNAs (pcRNAs) encoding parts of the mitochondrial genome ...of mitochondrial pcRNA delivery. A protozoan- derived mitochondrial ...
10
Regulation of muscle mitochondrial design
... Isoform shifting provides a cell with plasticity by allowing it to respond to physiological or developmental cues by producing a protein demonstrating a more appropriate function. Evolutionary processes also give rise to ...
9
“Mitochondrial remodeling” in coronary heart disease
... Abstract: Coronary heart disease is a major cause of morbidity and mortality in advanced countries. Despite remarkable developments and achievements in the field of coronary inter- vention, such as percutaneous catheter ...
12
jbc.M117.812834.full.pdf
... that mitochondrial membrane phospholipidome remodeling was having on respiratory complex activity, it is noteworthy that coupled ADP- stimulated respiration was not altered with EPA and DHA (data not ...of ...
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Mitocans as Novel Agents for Anticancer Therapy: An Overview
... [13,14]. Electrons are transported through the mitochon- drial respiratory complexes during oxidative phosphory- lation and this establishes a proton gradient across the mitochondrial membrane for ATP production. ...
15
Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes
... ABSTRACT A dozen mRNAs are edited by multiple insertions and/or deletions of uridine residues in the mitochondrion of Trypanosoma brucei. Several protein com- plexes have been implicated in performing this type of RNA ...
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Clinical Determinants and One Year Follow-Up of Dementia and Mild Cognitive Impairment following Ischemic Stroke.
... Cognitive impairment and presence of significant cerebrovascular disease are common to all criteria, but the method of establishing their presence and the causal relationship between them is ...
100
Residual effects of sleep medication on driving ability
... of impairment are included for illustrative purposes, and it must be kept in mind that the SDLP increments for alcohol were found in healthy volunteers, whereas the subjects in on-the-road driving studies ...
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Mitochondrial quality control mechanisms and the PHB (prohibitin) complex
... mitochondrial dynamics, mitophagy and the mitochondrial unfolded protein response (UPR mt ).. We.[r] ...
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Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists
... generally, mitochondrial function is highly degenerate (65, ...the mitochondrial Fe-S cluster assembly pathway by a bacterial type “Nif”-type system ...
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