Mitochondrial membrane depolarization
Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome
... and mitochondrial damage constitutes an early indicator of cell death in platelets ...[25,33,39,40], mitochondrial dysfunction is not an exclusive sign of cell death and can also occur with microcirculatory ...
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A Caspase-activated Factor (CAF) Induces Mitochondrial Membrane Depolarization and Cytochrome c Release by a Nonproteolytic Mechanism
... A family of cysteine proteases, termed caspases, plays a central part in both induction and execution of apop- tosis mediated by Fas and the p55 TNF receptor. Caspases are expressed as inactive zymogens and become ...
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Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5
... a mitochondrial protein, and a rabbit oligoclonal antibody to cytochrome c (Invitrogen; 710,627, 5 μg ml − 1 ) were diluted in 1% BSA and cover- slips were incubated overnight at 4 ...
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Adaptive respiratory response of rat pancreatic acinar cells to mitochondrial membrane depolarization
... and mitochondrial membrane potential was assessed with rhodamine123 ...on mitochondrial membrane potential and increased respiration elasticity coefficient with respect to the membrane ...
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β sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA MB 231 cells
... The current study shows that β -Sitosterol (ST), a dietary phytosterol has stronger anticancer activity against breast cancer cells compared to lung and skin cancer cells which may be attributed to the differential ...
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Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl 1
... toward mitochondrial depolarization-induced apoptosis were highly selective and were not observed in response to any of the other proapoptotic stimuli used (Figures 1C, 2A, and ...other mitochondrial ...
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Neuroprotective Effects of Caffeine on a Maternally Separated Parkinsonian Rat Model
... Maternal separation plays a major role in affecting proper development of the neurocircuitry. These disruptions early in life have enduring effects and predispose the rat to be particularly vulnerable to ...
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S-nitrosylation of connexin43 hemichannels elicits cardiac stress–induced arrhythmias in Duchenne muscular dystrophy mice
... Figure 6. NO-activated currents from oocytes expressing Cx43 hemichannels. (A) Representative current traces before and after application of 10 μM DEENO in a noninjected oocyte or an oocyte expressing Cx43. Oocytes were ...
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In vitro action of bombesin on amylase secretion, membrane potential, and membrane resistance in rat and mouse pancreatic acinar cells A comparison with other secretagogues
... caused depolarization of rat or mouse pancreatic acinar cell membrane, reduction of membrane resistance, and a steep rise in amylase output from superfused pancreatic ...the membrane action of ...
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Endothelial mitochondria determine rapid barrier failure in chemical lung injury
... the mitochondrial depolarization resulted from alveolar HCl–initiated H 2 O 2 diffu- sion from the alveolar epithelium, we transfected the alveolar epithelium with ...the mitochondrial ...
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Ionic Mechanism of Thermoreception in Paramecium
... In the anterior fragment, an increase in the frequency of directional changes in swimming and depolarization of the membrane was produced by cooling below the temperature of the culture.[r] ...
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Original Article Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
... into 50 μl of prepared mitochondrial suspen- sion for 10 s, then 50 μl of ANT inhibitor ATR (3.2 nmol/L) was added and mixed immediate- ly to terminate ANT transporter function. The mixture was centrifuged for 20 ...
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Electrical Responses of the Carnivorous Ciliate Didinium Nasutum in Relation to Discharge of the Extrusive Organelles
... Effects of the membrane depolarization and hyperpolarization produced by injection of electric currents on the electrical responses of Didinium nasutum in association with the discharge [r] ...
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Calmodulin antagonists effect on Ca(2+) level in the mitochondria and cytoplasm of myometrium cells
... with participation of calmodulin. We had shown in a previous work using two experimental models: isolated mitochondria and intact myometrium cells, that calmodulin antagonists reduce the level of mitochondrial ...
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Increased susceptibility of striatal mitochondria to calcium-induced permeability transition
... Mitochondrial depolarization could be caused by increased permeability of the inner mitochondrial membrane, inhibition of respiration, or ...to depolarization of both types of ...
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1 Mitochondrial dynamics in stem cells and
... mitochondrial outer membrane (MOM) fusion, mediated by mitofusin proteins (Mfn1 and Mfn2) 48.. [13-17] and mitochondrial inner membrane (MIM) fusion, mediated by Opa1, and could be poss[r] ...
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Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
... the membrane and the cytoplasm [36, 51, ...and membrane translocation of p47phox are critical for apocynin-mediated protective potentials against oxidative stress (mitochondria > cytosol), neu- ...
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Original Article Ulinastatin mediates protection against vascular hyperpermeability following hemorrhagic shock
... estimation. Mitochondrial release of cytochrome c and caspase-3 activation was esti- mated in ...assay; mitochondrial mem- brane potential (∆Ψ m ) was determined with JC-1; intracellular ATP content was ...
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The mitochondrial origin of postischemic arrhythmias
... sarcolemmal APD were triggered after a highly localized laser flash (3 minutes before the train of oscillating APDs shown in this panel). APs evoked by brief current injections were recorded during the oscillations. ...
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Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization
... pro-apoptotic mitochondrial network abnormalities were attributed to the Drp1 pathway, we analyzed the effect of TRAIL on the mitochondrial network in A375 cells in which Drp1 protein levels were down- ...
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