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Mitochondrial ROS

Mitochondrial ROS deficiency and diabetic complications: AMP[K] lifying the adaptation to hyperglycemia

Mitochondrial ROS deficiency and diabetic complications: AMP[K] lifying the adaptation to hyperglycemia

... of ROS has deleterious effects on tissue struc- ture and function and gives rise to biochemical and physiological changes associated with organ ...localized ROS metabolites gen- erated by mitochondria and ...

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Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

... In this paper, we report beneficial effects of the ROS-redox modulator small molecule KH176 in the ubiquitous OXPHOS complex I-deficient Ndufs4−/− mouse model based on the loss of brain [r] ...

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Stress induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production

Stress induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production

... mitoSTAT3(4, 5), MEK and ERK inhibition did not affect mitoSTAT3 abundance. This is not surprising because various other kinases can phosphorylate STAT3 at this residue, and there is likely a large degree of crosstalk ...

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The spatial and temporal relationship between oxidative stress and neuronal degeneration in 3 nitropropionic acid model

The spatial and temporal relationship between oxidative stress and neuronal degeneration in 3 nitropropionic acid model

... of mitochondrial reac- tive oxygen species in the presence of 3NP in male Sprague-Dawley ...in mitochondrial ROS following 3NP in either stria- tum or cerebellum; however, calcium addition resulted ...

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SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo

SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo

... significant mitochondrial fusion under oxidative stress (Figure ...of mitochondrial ROS, the dissipation of mitochondrial membrane potential and the reduced intracellular ATP level were ...

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Mitochondria-Modulating Porous Se@SiO2 Nanoparticles Provide Resistance to Oxidative Injury in Airway Epithelial Cells: Implications for Acute Lung Injury

<p>Mitochondria-Modulating Porous Se@SiO<sub>2</sub> Nanoparticles Provide Resistance to Oxidative Injury in Airway Epithelial Cells: Implications for Acute Lung Injury</p>

... numerous mitochondrial-targeting nanodevices have been designed as antitumor strategies and exhibited remarkable ...amplify mitochondrial ROS (mtROS) and endow long-term excessive oxidative stress, ...

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The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism

The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism

... of mitochondrial ROS pro- duction, this study aimed to elucidate whether alterations on the expression levels of SIRT1, SIRT3, SOD2, and lipid peroxidation status are related to the observed oxidative ...

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Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy

Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy

... DR include apoptosis of peripheral blood cells, micro- vascular occlusion, vascular leakage and microaneurysm [30]. REC is the first barrier to sense the changes in blood glucose and the main target of attack from dia- ...

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A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species‐induced delayed cell death

A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species‐induced delayed cell death

... showing mitochondrial morphology in cells treated by bafilomycin or pre-treated with inhibitors for 30 min before bafilomycin ...showing mitochondrial ROS (MitoROS) generation in cells treated by ...

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Decreased hydrogen peroxide production and mitochondrial respiration in skeletal muscle but not cardiac muscle of the green striped burrowing frog, a natural model of muscle disuse

Decreased hydrogen peroxide production and mitochondrial respiration in skeletal muscle but not cardiac muscle of the green striped burrowing frog, a natural model of muscle disuse

... increased ROS production in disused fibres (Min et ...in mitochondrial ROS production and this has only recently received experimental attention in natural models of muscle disuse (Brown et ...

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Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

... increasing mitochondrial density ...and ROS, while switching to easily stored fatty ...in mitochondrial ROS and activation of AMPK; the inference is that glycol- ysis, although inefficient, ...

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Cancer stem cell metabolism

Cancer stem cell metabolism

... a mitochondrial ROS inducer such as menadione do not become resistant, suggesting that increasing mitochon- drial ROS levels to non-viable levels might be a better approach to eliminate CSCs ...

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NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis

NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis

... in mitochondrial biogenesis appears to be critical for sustaining the profibrotic phenotype of ...47). Mitochondrial biogenesis was significantly reduced with a deficiency of either ...factor. ...

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Differential activation of RAW 264.7 macrophages by size-segregated crystalline silica

Differential activation of RAW 264.7 macrophages by size-segregated crystalline silica

... macrophages. This study provided novel data showing that UF silica particles enhance the activation of AM when compared to larger silica particles usually represented in in vitro and in vivo research. These data ...

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Coordinate expression of heme and globin is essential for effective erythropoiesis

Coordinate expression of heme and globin is essential for effective erythropoiesis

... not mitochondrial) ROS, which does not include traditional markers of apoptosis such as mitochondrial cytochrome c release or caspase activation ...heme-induced ROS causes a slow cell death ...

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The Effect of CCCP on Mitophagy in CD4 CD25 Regulatory T Cells in Human Peripheral Blood

The Effect of CCCP on Mitophagy in CD4 CD25 Regulatory T Cells in Human Peripheral Blood

... cell. ROS can oxidise non-fluorescent DCFH to fluorescent DCF, so the fluorescence of DCF can reflect the level of ROS in cells, the higher the fluorescence of DCF, the higher the level of ...P<0.05, ...

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Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS

Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS

... rotenone. ROS generation was measured by 2′,7′-dichloro- fluorescin ...of ROS production was demonstrated in the presence of ...depolarized mitochondrial membrane either under oxidative stress or ...

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Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease

Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease

... cellular ROS have been shown to result in a reduction of telomerase activity, which can be prevented by the pres- ence of ROS scavengers which also delay the onset of cel- lular senescence ...

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Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction

Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction

... of mitochondrial membrane potential was observed (the magnification for the figure is 200×) after the cells were exposed to Ir (3 μM), equivalent lipo-Ir for 24 h, or cccP (as positive ...

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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

... the mitochondrial outer membrane are tar- geted for degradation in a proteasome- and PSMD2 (proteasome [prosome, macropain] 26S subunit, non-ATPase, 2)-dependent manner, which are required for PARK2-mediated ...

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