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mitogen-activated protein kinase 14

MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts

MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts

... G protein- coupled signaling pathways including mitogen-activated protein kinase (MAPK), which subsequently induce sev- eral cellular responses including gene expression and pulmonary ...

11

Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts

Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts

... serine/threonine protein phosphatase 1 (PP1) and/or PP2A as the downstream effector of p38 MAPK ...the kinase Raf-1 in vivo (Abraham et ...for 14-3-3 proteins, which are involved in suppression of ...

12

PKM2, function and expression and regulation

PKM2, function and expression and regulation

... a protein kinase, which forms a complex with β-catenin and binds to the CCND1 promoter region to phosphorylate histone H3, and phosphorylated histone H3 is separated from histone deacetylase 3, which will ...

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Mitogen-Activated Protein Kinase Pathways and Fungal Pathogenesis

Mitogen-Activated Protein Kinase Pathways and Fungal Pathogenesis

... scaffold protein Ste5 and a p21- activated protein (PAK) kinase, Ste20, and is essential for the activation of the Ste11-Ste7–Fus3/Kss1 ...dependent kinase inhibitor Far1 and the Ste12 ...

14

Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.

Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.

... The PKCl gene product, protein kinase C, regulates a mitogen-activated protein kinase (MAPK) cascade, which is implicated in cell wall metabolism.. Previously, we i[r] ...

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Identification of Top-ranked Proteins within a Directional Protein Interaction Network using the PageRank Algorithm: Applications in Humans and Plants

Identification of Top-ranked Proteins within a Directional Protein Interaction Network using the PageRank Algorithm: Applications in Humans and Plants

... extracellular-signal-regulated kinase (ERK) (MAPK signaling pathway) phosphorylate distinct sites on TSC2, and thus its Rheb GTPase-activating protein (GAP) activity is more repressed and, consequently, the ...

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Cryptococcus neoformans Gene Expression during Murine Macrophage Infection

Cryptococcus neoformans Gene Expression during Murine Macrophage Infection

... The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and proliferates within, ultimately establishing latent infection as a facultative intracellular pathogen that can escape macrophage ...

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Supplementing L-isoleucine increases medium protein and alters the expression of genes and proteins involved in milk protein synthesis and energy metabolism in bovine mammary cells

Supplementing L-isoleucine increases medium protein and alters the expression of genes and proteins involved in milk protein synthesis and energy metabolism in bovine mammary cells

... for protein quantification using a bicinchoninic acid assay ...for protein quantification by BCA using the Pierce Protein Assay Kit (Pierce Biotechnology, ...

14

MAP2K6 is associated with radiation resistance and adverse prognosis for locally advanced nasopharyngeal carcinoma patients

MAP2K6 is associated with radiation resistance and adverse prognosis for locally advanced nasopharyngeal carcinoma patients

... tory factor (LIF) receptor was linked to MAPK. An obvious dose–response relationship was observed when 3T30L1 (cell extracts) processed by LIF in vitro was bound to the intracel- lular domain of LIF receptor. The ...

8

Kinase Activity Profiling of Gram-Negative Pneumonia

Kinase Activity Profiling of Gram-Negative Pneumonia

... approach. Kinase activity arrays enable the analysis of 1,024 con- sensus sequences of protein kinase ...a kinase activity array on whole lung lysates, cellular kinase activities were ...

7

Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3

Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3

... vitro protein kinase assay using recombinant RBM8A and ...GSK-3 protein to conduct in vitro kinase ...vitro kinase reaction with recombinant PSF and GSK-3 confirmed that Thr679 is ...

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Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)

... on mitogen-activated protein kinase-activated protein kinase 5 ...MK5 protein is a highly conserved protein kinase within vertebrates sharing 87 to ...

21

Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways

Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways

... The cells were sorted with CD31 Dynabeads, Endothelial Cell (Invitrogen 111.55D; Life Technologies, Grand Island, NY) according to the manufacturer’s instructions. The cells were washed with PBS and trypsinized with ...

12

Stem cells and the impact of ROS signaling

Stem cells and the impact of ROS signaling

... Reactive oxygen species (ROS) have been increasingly implicated in the physiological regulation of crucial developmental processes, e.g. the emergence of embryonic blood stem cells or differentiation of embryonic ...

13

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

... interacting protein kinase (HIPK) 2 and 3, I-kappa B Kinase (IKK), mitogen-activated pro- tein kinase 1 (MAPK2/ERK2), ribosomal protein S6 kinase, 90 kDa, ...

10

Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod

Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod

... The observation of BNP lowering and improved MRI parameters of remodeling post-infarct among losmapimod- treated patients in SOLSTICE is interesting. This potential protective effect of p38 MAPK inhibition on heart ...

8

Multimerization of Adenovirus Serotype 3 Fiber Knob Domains Is Required for Efficient Binding of Virus to Desmoglein 2 and Subsequent Opening of Epithelial Junctions

Multimerization of Adenovirus Serotype 3 Fiber Knob Domains Is Required for Efficient Binding of Virus to Desmoglein 2 and Subsequent Opening of Epithelial Junctions

... Cross-linking of Ad3 fiber knobs is required for efficient binding to DSG2. We then focused our attention on the Ad3 fiber. We produced in E. coli a series of recombinant Ad3 fiber knob proteins containing the fiber knob ...

13

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.

... While MA tyrosine phosphorylation has been shown to fa- cilitate HIV-1 nuclear import (6, 18, 19), the functional signif- icance of MA serine phosphorylation remains unclear. The treatment of virus producer cells with ...

6

Regulation of Sox9 activity by crosstalk with nuclear factor κB and retinoic acid receptors

Regulation of Sox9 activity by crosstalk with nuclear factor κB and retinoic acid receptors

... Sox9 protein level or altered ...nuclear protein lev- els. Moreover, TNF-α did not alter the level of protein com- plexes bound to the Col2a1 48-bp minimal enhancer ...Sox9 protein levels over ...

12

English_unc_0153D_14626.pdf

English_unc_0153D_14626.pdf

... diffusion 80 . From these experiments it is evident that Hog1 is activated processively and phosphorylated maximally in response to low doses of osmostress. In particular, we observed full activation of Hog1 ...

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