Molecular Profiling
Cancer diagnostics: The journey from histomorphology to molecular profiling
... and molecular profiling, there are currently no perfect methods to guide cancer ...in molecular diagnosis and targeted therapy by offering a combined or integrated tumor classification ...limit ...
13
Elemental and molecular profiling of licit, illicit and niche tobacco
... develop a spectral library of tobaccos to aid rapid identification of unknown samples. The observation of palladium within EDX spectra sees the detection of residual palladium (II) containing pesticides, which are ...
35
Handling of Clinical Tissue Specimens for Molecular Profiling Studies
... for molecular profiling is significantly influenced by the manner of specimen ...allow molecular profiling analysis and the use of a web- based 3-dimensional model to combine these data to ...
10
Molecular profiling in the treatment of colorectal cancer: focus on regorafenib
... mutation profiling for EGFR ...The molecular and genetic markers associated with regorafenib treatment response are yet to be ...mCRC molecular profiling, such as RAS, BRAF, and MMR testing, ...
9
Staging of biliary atresia at diagnosis by molecular profiling of the liver
... into molecular inflammation or fibro- sis and found significant association with age at portoen- terostomy and transplant-free ...that molecular profiling at diagnosis may stage the liver disease by ...
13
Automated tumor analysis for molecular profiling in lung cancer
... of molecular biomarkers in solid tumors, increasingly relies on nucleic acid extraction from FFPE tissue sections and subsequent molecular ...NSCLC molecular evaluation and emphasising the need for ...
15
Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.
... This thesis aimed to evaluate some of these aspects related to outcome of TJA, from patient perspectives to molecular profiling (e.g. metabolic health). Characteristics of different nature were included: ...
167
Treatment of patients with refractory metastatic cancer according to molecular profiling on tumor tissue in the clinical routine: an interim-analysis of the ONCO-T-PROFILE project
... From March 2014 until April 2015, 50 patients with refractory solid cancer were enrolled in our ONCO-T- PROFILE project. As illustrated in Figure 1, so far, 19 patients were treated according to molecular ...
8
Comprehensive molecular profiling of lung adenocarcinoma.pdf
... report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...
8
Molecular profiling of patient derived breast cancer xenografts
... Preclinical experimental models that reproduce the heterogeneity of this disease have become a major chal- lenge in order to investigate the biology of each BC sub- type and evaluate new targeted therapies. Such models ...
14
Post-mortem molecular profiling of three psychiatric disorders
... underlying molecular pathologies within and across these types of disorders are necessary to address the immense burden of psychiatric disease around the world and improve care for the millions of people diagnosed ...
12
Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?
... Abbott Molecular, Des Plaines, IL, USA), ROS1 (ZytoLight SPEC ROS1 Dual Color Break Apart Probe, Zytovision, Bremerhaven, Germany) and EGFR (Vysis LSI EGFR spectrumOrange/ CEP7 spectrumGreen Probe, Abbott ...
12
Molecular profiling of bacterial species in the geese cecum
... by molecular analysis of 16S rRNA ...as molecular analysis of 16S rRNA genes have shown greater diversity of the bacterial population than had been achieved by culture-dependent methods (Gong et ...
12
Molecular profiling of dilated cardiomyopathy that progresses to heart failure
... phenotypically normal yet displayed proliferation of nonmyocytes (59% relative increase vs. WT, P = 8 × 10 –4 ) and activation of proinflammatory signaling with notable cardiomyocyte- specific induction of a subset of ...
19
Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity
... global molecular profiling technologies, we identified obesity-related gene expression changes paired with changes in DNA methylation, noting coordinated changes in the PI3K/AKT signaling pathway, ...
12
Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand
... Ex vivo drug susceptibility testing and molecular profiling of clinical Plasmodium falciparum isolates from Cambodia from 2008 to 2013 suggest emerging piperaquine resistance.. Antimicro[r] ...
12
In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane
... Molecular profiling of angiogenic factors after treatment with HRL indicated that angiogenic potential of leptin mainly depends on the functional activation of VEGF A (VEGF 165) and ...
13
OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing
... expression profiling using RNA-Seq generates vast amounts of ...performing molecular profiling, assessing altered genes and pathways, identifying mutations and fusion gene transcripts and by ...
8
Cost-comparison analysis of a multiplatform tumour profiling service to guide advanced cancer treatment
... One major concern of this analysis is the great diver- sity of cancer patients included in studies on molecular profiling. Patients usually do not have the same stage or clinical presentation and this may ...
5
Precision medicine in pediatric oncology
... current molecular profiling programs for patients with relapsed or refractory tumors aim to sequence tumor ge- nomes, in order to identify genetic alterations and switch off related genes with targeted ...
15