monoclonal anti-CD8 antibodies
Targeted suppression of autoreactive CD8+ T cell activation using blocking anti CD8 antibodies
... This monoclonal system allowed a rigorous evaluation of DK25-mediated effects as a function of a single variable parameter, namely the affinity of the TCR/pMHCI ...
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Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
... following antibodies: anti- CD11c monoclonal (dendritic cells/inflammatory cells) (Abcam, cat ...RT), anti-CD4/CD8 monoclonal antibodies (Novocastra, cat ...hours), ...
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Anti CTLA4 monoclonal antibodies: the past and the future in clinical application
... Other potential biomarkers could be the mean rate of CD8 change, the resistance of CD4+ T cells to Treg mediated inhibition in vitro, and the frequency of IL-17 secreting CD4+ T cells [20]. Even biomarkers in the ...
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Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats.
... To determine the contribution of different T-cell subsets to the pathogenesis of Borna disease, virus-infected rats were treated with monoclonal antibodies specific for CD4+ and CD8+ cel[r] ...
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Anti-CD19 Monoclonal Antibodies: a New Approach to Lymphoma Therapy
... which is composed of two single chain antibodies (scFvs) to both CD19 and CD3 that are connected via a flexible linker (32-34). Blinatumomab was developed by Micromet and entered phase 1 for NHL in 2004 (12). It ...
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Establishment of anti mesothelioma monoclonal antibodies
... and CD8 cytotoxic T cells or ingested by ...produce antibodies against the tumor cells. These antibodies probably make a major contribution to the rejection of the tumor ...establishing ...
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Trypanosoma cruzi Bromodomain Factor 3 Binds Acetylated α-Tubulin and Concentrates in the Flagellum during Metacyclogenesis
... cruzi, antibodies raised against recombinant protein were purified by affinity ...mouse antibodies showed a single band of the expected molecular weight in total lysates of ...rabbit anti-TcBDF3 ...
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Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down’s syndrome, preterm delivery and preeclampsia
... LHR74 antibodies were initially pro- vided by Dr Hugues Loosfelt (INSERM, France) and subsequently the antibody producing clones were obtained from ATCC (Clone ID CRL-2685 and CRL- ...2686). Antibodies ...
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Therapeutic treatment of New Zealand mouse disease by a limited number of anti idiotypic antibodies conjugated with neocarzinostatin
... of anti-Id antibodies conjugated with NCS brought about an improvement in the survival rate of female NZB/W F1 ...of anti-DNA-producing cells. The suppression of anti-DNA antibody synthesis ...
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Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis.
... We now report that i MAbs specific for each of the reovirus outer capsid proteins and the core spike protein are protective under certain circumstances, ii MAb protection does not univer[r] ...
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Monoclonal yeast killer toxin-like candidacidal anti-idiotypic antibodies.
... few anti-idiotypes might strictly meet the structural requirements of internally imaged KTs for the functional interaction with the KTRs of sensitive microorganisms, it is reasonable to assume that the action of ...
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Novel Antibody Lectin Enzyme Linked Immunosorbent Assay That Distinguishes Prion Proteins in Sporadic and Variant Cases of Creutzfeldt Jakob Disease
... specific for the N-linked glycans. We also depleted the full- length PrP species in the brain homogenates with MAb 8B4- conjugated beads prior to the MAb 8B4-lectin ELISA. Re- moval of the full-length PrP species also ...
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Development and Evaluation of a Novel ELISA for Detection of Antibodies against HTLV-I Using Chimeric Peptides
... An indirect ELISA was established with the use of chimeric peptide as a coating antigen and a monoclonal HRP-conjugated anti-human IgG for the detection of antibodies to HTLV-I in human sera. The ...
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Thymic hyperplasia in patients with Graves' disease Identification of thyrotropin receptors in human thymus
... mouse anti–human TSH- receptor mAb (1:250; TRANSBIO, Boulogne, France), which recog- nize amino acids 604–764 of human TSH receptor (24), overnight at 4 8 C, and visualized by a biotin-streptavidin–amplified ...
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Interactions of CD4+ and CD8+ human T lymphocytes from malaria unprimed donors with Plasmodium falciparum schizont stage
... Monoclonal antibodies to CD3 or the aji-chain T-cell receptor blocked cloned T-cell responses to the schizont extract, and although the responses of the majority of the CD4+ or CD8+ T-ce[r] ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... To our knowledge, this is the first study to analyze the correla- tions between PD-1 and KIR. We observed KIR expression before and after anti-PD-1 monoclonal antibody treatment. We found that the ...
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Molecular properties of human monoclonal anti-DNA and antiphospholipid antibodies
... The major drawbacks of bacterial expression of eukaryotic proteins are that post-translational modifications such as glycosylation are absent and that the molecules may not be folded properly. This applies particularly ...
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Origins of anti DNA autoantibodies
... The animals responded by producing both anti-cardiolipin and anti-DNA antibodies, and hybridomas prepared from their spleens yielded monoclonal antibodies that were indistinguishable fro[r] ...
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Role of the Metabolic Minor Components in the Regulation of Intermolecular Interaction
... with monoclonal antibodies labeled by fluorescein isothiocyanate, which is reflected in the change of the conformational structure of the protein molecule and the ability of antigens to form complexes ...
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Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women
... The lymphoid compartment of the thymus was examined by immunohistological staining using monoclonal antibodies directed to the CD4 and CD8 antigens (Becton-Dickinson, Sunnyvale, CA, and [r] ...
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