MTHFR 677C>T mutation
The Prevalence of Mther 677C >T Missense Mutation, Total Plasma Homocysteine Levels and Associated Risk Factors in Malay Subjects
... The Prevalence of Mther 677C→T Missense Mutation, Total Plasma Homocysteine Levels and Associated Risk Factors in Malay Subjects ORIGINAL ARTICLE The Prevalence of MTHFR 677C 7T Missense Mutation, Tot[.] ...
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ARMS-PCR Based SNP Analysis of MTHFR C677T Allele Using Syber Green in Pancreatic Tumour
... The MTHFR 677 TT genotype led to elevated homocysteine levels and DNA hypomethylation in folate-depleted subjects lead to provide the genomic instability, leading to ...677TT mutation (33%) of MTHFR ...
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Polymorphism study of MTHFR 677C?T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq Muthanna A. Thabit| Gaylany H. Abdullah | Khalid F. AL-Rawi1
... Oxidative stress is linked to female infertility due to its influence on many causes that lead to female infertility such as PCOS and endometriosis and raised the risk of female infertility. The results show a ...
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Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C -> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels
... point mutation, C!T substitution at nucleotide 677 (677C!T), in the coding region of the gene for methylenetetrahydrofolate reductase (MTHFR), resulting in a thermolabile MTHFR ...
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RESEARCH ARTICLE Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese
... in MTHFR gene, and an exonic polymorphism, 677C>T is the widest researched ...The mutation of this polymorphism can result in the conversion of valine to alanine at codon 222, and is linked ...
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Association of Methylenetetrahydrofolate Reductase (MTHFR 677C>T and 1298A>C) Polymorphisms and Haplotypes with Silent Brain Infarction and Homocysteine Levels in a Korean Population
... the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI and plasma homocysteine concentration in a Korean ...the MTHFR gene was carried ...the MTHFR 677TT genotype ...
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Original Article Relationship of folate metabolism related enzymes MTHFR and MTRR gene polymorphisms with unexplained recurrent spontaneous abortion
... The PCR amplification primers and probes of MTHFR C677T and A1298C genetic loci and MTRR A66G genetic locus are shown in Tables 1 and 2. Related instruments and reagents are the products of US Applied Biosystems ...
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Inherited Genetic Markers for Thrombophilia in Northeastern Iran (a Clinical-Based Report)
... Fig. 1. Agarose gel electrophoresis of samples from thrombophilia patients; (A) Analysis of the A1298C polymorphism in the MTHFR gene. The samples were PCR-amplified and digested with MboII. Samples in lanes 1, 2, ...
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Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters
... S-adenosylmethionine, the methyl group donor necessary for DNA synthesis, cell division, tissue growth, among other reactions. Methionine is also essential for DNA methylation as it plays an important role during ...
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MTHFR 677C T and 1298A C Gene Polymorphisms and Its Relation to Levels of Homocysteine, Folate Vitamin B 12
... The enzyme 5, 10 methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in folate and homocysteine metabolism. Folate is implicated in carcinogenesis due to its role in DNA methylation, repair and ...
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<p>Plausible relationship between homocysteine and obesity risk via <em>MTHFR</em> gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization</p>
... that MTHFR 677T allele had an elevated obesity risk with a ...with MTHFR 677C allele in Indian ...between MTHFR C677T and overweight/obesity, the results are con- troversial in different ...
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“Association of Apolipoprotein E, Methylenetetrahydrofolate genotypes, Lipids levels and Alzheimer disease in an Algerian Population” by A.Ouldjaoui, N.Abadi, K.Sifi, Y.Sifi, A. Hamri, C.Benlatreche, Algeria.
... Blood samples were drawn after an overnight fasting into EDTA-containing tubes for analysis of ApoE, MTHFR genotypes and lipid parameters. The dosage of cholesterol and triglycerides have been done by an ...
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Factor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
... Anticoagulated blood was collected from all the participants. Genomic DNA was isolated using SinaClone DNA extraction kit. Primers with the sequences mentioned in Table 1 were purchased from Invitrogen (USA). RFLP ...
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Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation
... levels, MTHFR C677T polymorphism, aging, and ultimately, ...the MTHFR C677T and lipid profiles in long-lived individuals may thus help to provide insight into the biology of human aging and aging-related ...
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Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
... The statistical analysis and graphs were conducted using JMP 10 software. Gaussian variables were expressed as mean ± standard deviation, while median results were re- ported for any data that was not normally ...
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The Relationship Between Homocysteine Levels With The Degree of Severity In Patients With Acute Phase Ischemic Stroke At Haji Adam Malik General Hospital Medan
... Total Normal Homocysteine concentration (tHcy) ranges from 5-15 μmol / L in the fasting state. Hyperhomocysteinemia (HHcy) are classified as moderate (plasma tHcy concentration 15–30 µmol / L), intermediate (plasma tHcy ...
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Effectiveness of Bemiparin Sodium for Preventing Pregnancy Loss in Patients with MTHFR C677T Mutation and Habitual Abortus
... Venous blood of 2 cc were obtained in test tubes containing ethylenediaminetetraacetic acid (EDTA) from all patients with a history of RPL and stored in special containers at +4 degrees celsius, afterwards all stored ...
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MTHFR ), an enzyme involved in homocysteine
... The main results of meta-analysis and hetero- geneity test were summarized in Table 2. Overall, the pooled results showed a significant association between MTHFR C677T polymor- phism and the risk of VaDunder ...
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Is thrombophilia a major risk factor for deep vein thrombosis of the lower extremities among Lebanese patients?
... Aim: Factor V Leiden (R506Q) mutation is the most commonly observed inherited genetic abnormality related to vein thrombosis. Lebanon has one of the highest frequencies of this mutation in the world with a ...
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Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein 1
... Abstract Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyper- homocysteinemia), which is usually ...
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