multiple mutations
Multiple- mutations in the katG gene of Mycobacterium tuberculosis isolates correlate with high- level of resistance to isoniazid in patients with active pulmonary tuberculosis from Belarus
... of mutations, which may be important for achieving the higher level of resistance or maintaining virulence in a human ...of mutations, ultimately leading to katG and/or inhA mutations in virtually ...
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High Level Rifampin Resistance Correlates with Multiple Mutations in the rpoB Gene of Pulmonary Tuberculosis Isolates from the Afghanistan Border of Iran
... of multiple mutations in the rpoB gene as well as predominant nucleotide changes and their correlation with high levels of resistance to rifampin (rifampicin) in Mycobacterium tuberculosis isolates that ...
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Multiple mutations of lung squamous cell carcinoma shared common mechanisms
... whether mutations of two different genes co-occurred and the lower triangle showed that whether the expression levels of two different genes were ...their mutations occur simultaneously. But mainly, these ...
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Hepatitis B Surface Antigen Variant with Multiple Mutations in the a Determinant in an Agammaglobulinemic Patient
... revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype ...these mutations had a profound effect on the antigenicity of this region, ...
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The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations
... of mutations was increased from one to four ...of mutations. Alternatively, the 3 putative phosphorylation site mutations that were not tested individually (S151A, T220A and T224A) may have been ...
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Emerging 8 Methoxyfluoroquinolone Resistance among Methicillin Susceptible Staphylococcus epidermidis Isolates Recovered from Patients with Endophthalmitis
... Fluoroquinolone resistance among staphylococci endophthalmi- tis isolates is a major and increasing concern in ophthalmology. The documentation of high-level moxifloxacin and gatifloxacin resistance in ...
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Predicting the combined effect of multiple genetic variants
... for multiple types of variation ...by multiple genes and/or multiple mutations on individ- ual genes [7], so quantitatively measuring the effect of multiple variants together should be ...
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Mutation hot spots in Spike protein of COVID-19
... showed multiple mutations at few frequent locations whereas some of the parts of this protein was seen to be ...of mutations observed in isolates of USA. Although there were many mutations ...
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Identification of the multiple beta thalassemia mutations by denaturing gradient gel electrophoresis
... beta-thalassemia mutations in the Chinese ...known mutations on the basis of the mobility of the homoduplexes and ...detecting multiple mutations in genetic ...
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Mutations in sfdA and sfdB Suppress Multiple Developmental Mutations in Aspergillus nidulans
... C ONIDIATION of Aspergillus nidulans follows a de- Genes that are important for normal brlA activation velopmental program of cell differentiation to re- and development have been identified by mutational sult in the ...
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<p>Mutations In Thirty Hotspot Genes In Newly Diagnosed Chinese Multiple Myeloma Patients</p>
... revealed mutations in 66% of the 47 analyzed ...in multiple myeloma by Lohr et al, the most commonly mutated genes were KRAS, NRAS, FAM46C, DIS3 , and TP53 , 2 while in our study the most commonly mutated ...
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RDL mutations predict multiple insecticide resistance in Anopheles sinensis in Guangxi, China
... Methods: Two hundred and forty adults of An. sinensis collected from nine locations across Guangxi Zhuang Autono- mous Region were used. Two fragments of An. sinensis RDL (AsRDL) gene, covering the putative insecticide ...
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Mutations in the Ty3 major homology region affect multiple steps in Ty3 retrotransposition.
... these mutations in the more complex but physiological context of the Ty3 Gag3 and Gag3-Pol3 proteins, the Q86R, G87V, E90D, E90N, E90K, and Q98R mutations were introduced into a Ty3 element carried on the ...
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The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients
... EGFR-TKI osimertinib is a potent and irreversible EGFR inhibitor. Osimertinib effectively slows disease progres- sion in NSCLC patients with both exon 19del and L858R mutations and T790M resistance ...
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Cutaneous mosaicism: right before our eyes
... of multiple mechanisms, including decreased cell and growth factor response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of which can contribute to lack of heal- ing in persons ...
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A Population Genetic Study of the Evolution of SINEs. II. Sequence Evolution Under the Master Copy Model
... Since mutations that occur in the ancestral ele- ments at the master copy locus result in changes of nucleotide in present multiple elements, such muta- tions af[r] ...
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Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes
... Additional genetic analysis of mutations in the SAGA genes SPT20, SPT7, GCN5, and SPT3, strongly suggests that SAGA is required for multiple activities, only a subset [r] ...
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Integrating the processes in the evolutionary system of domestication
... if multiple different traits were fixed in parallel in different regions, then the resulting composite crop might be expected to have single mutations, but with different phylogeographic affiliations, Fig ...
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The Fitness Effects of Spontaneous Mutations Nearly Unseen by Selection in a Bacterium with Multiple Chromosomes
... of mutations has studied mutants that have been screened by selection, which presumably purged deleterious variants and enriched bene- ficial ...most mutations independent of the biases of natural ...
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Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene
... DIN1 mutations have been described (MIM#603718) and cause ichthyosis, vacuolated leukocytes and alopecia but without brain ...with mutations in the AMOT gene so ...JAM3 mutations [13] presented all ...
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