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multiple signal transduction pathway

Wnt signal transduction pathway and apoptosis: a review

Wnt signal transduction pathway and apoptosis: a review

... has multiple func- tional domains. APC is illustrative of the multiple roles that certain tumor suppressors play in a ...wnt signal transduction pathway, of adherens junctions, and the ...

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Model simplification of signal transduction pathway networks via a hybrid inference strategy

Model simplification of signal transduction pathway networks via a hybrid inference strategy

... for signal pathway networks. It integrates multiple techniques including conservation analysis, local sensitivity analysis, principal component analysis and flux analysis to identify the reactions ...

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Reactive oxygen species in signal transduction

Reactive oxygen species in signal transduction

... of multiple stimuli that increase the formation of ROS, such as angiotensin II [77], prostaglandin E2 [78] and shock waves ...signaling pathway, such as MKK3 and MKK6 [80], are also involved in the ...

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Advances in Targeting Signal Transduction Pathways.

Advances in Targeting Signal Transduction Pathways.

... of multiple points in a single signaling ...this pathway. However, this results in reactivation of ligand-dependent signal transduction and increased Ras activity and induces generation of ...

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NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

... Results are presented as the mean ± SD for at least three independent experiments for each group. Chi- squared exact test and Spearman correlation were applied to analyze the association between the expression of NRF2 ...

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Poxvirus MC160 Protein Utilizes Multiple Mechanisms To Inhibit NF-κB Activation Mediated via Components of the Tumor Necrosis Factor Receptor 1 Signal Transduction Pathway

Poxvirus MC160 Protein Utilizes Multiple Mechanisms To Inhibit NF-κB Activation Mediated via Components of the Tumor Necrosis Factor Receptor 1 Signal Transduction Pathway

... considered dispensable for this cytokine-mediated event (fi- broblasts from IKK1-deficient mice remain responsive to TNF- ␣ [26, 32]), it was initially perplexing as to how the MC160 protein’s effect on IKK1 altered ...

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Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction

Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction

... and signal transduction in mouse brain at various times after scrapie ...STAT signal transduction ...STAT signal trans- duction ...

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Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

... progression of cancer, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. High expression of EGFR has been observed in numerous human tumors, including lung, colon, breast, head and neck, ...

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Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans

Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans

... In the present study, we observed a significant correlation between the pa- tients’ age and MD development. This could be attributed to multiple genetic and mechanical factors. Experiments in rabbits have shown ...

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A Systems Approach to Cellular Signal Transduction

A Systems Approach to Cellular Signal Transduction

... of signal flow through diverging pathways downstream of the receptor, our calculations provided a mechanistic explanation for the clinical observation that therapeutic tyrosine kinase inhibitors can control tumor ...

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Signal transduction in vasculogenesis and developmental angiogenesis

Signal transduction in vasculogenesis and developmental angiogenesis

... Genetic studies have implicated the Notch signaling pathway in the regulation of angiogenesis. Notch 1 null mice die at E11 and although they possess a normal primary vascular plexus, they eventually display ...

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Signal Transduction with Hybridization Chain Reactions

Signal Transduction with Hybridization Chain Reactions

... In Section 2.6 we demonstrated that multiplexing with two HCR systems in a single test tube is feasible. Since the ability to multiplex more than two genes at once is highly useful in a variety of applications including ...

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Signal transduction in cells of the immune system in microgravity

Signal transduction in cells of the immune system in microgravity

... Cell migration is an essential characteristic of life. Multicel- lular organisms must be motile to obtain nourishment, evade being eaten in their own right, respond to environ- mental changes and reproduce. Likewise, ...

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Signal transduction by the Fat cytoplasmic domain

Signal transduction by the Fat cytoplasmic domain

... specifically impairs Fat-Hippo signaling (Cho et al., 2006; Feng and Irvine, 2009). A portion of Fat is phosphorylated on its intracellular domain (ICD); this phosphorylation depends upon both Ds and Dco, suggesting that ...

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Signal Transduction in the Footsteps of Goethe and Schiller

Signal Transduction in the Footsteps of Goethe and Schiller

... The Workshop Signalling Induced By Pathogens has established itself as a "traditional" constituent of the STS Meetings which readily reflects the increasing general interest in this research field. It is now that ...

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CO2 concentrating mechanism and signal transduction pathway associated with limiting CO2 acclimation in Chlamydomonas reinhardtii

CO2 concentrating mechanism and signal transduction pathway associated with limiting CO2 acclimation in Chlamydomonas reinhardtii

... reinhardtii cells grown in different CO2 and light conditions Im and Grossman, 2002; Im et al., 2003; Miura et al., 2004, and their analyses have revealed that in addition to L7/L12, sev[r] ...

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Original Article Role of TLR4/NF- B signal transduction pathway in the formation of bone cancer pain in rats

Original Article Role of TLR4/NF- B signal transduction pathway in the formation of bone cancer pain in rats

... Abstract: Background: To investigate the role of Toll-like receptor 4 (TLR4)/NF-κB signal transduction pathway in formation of bone cancer pain (BCP) in rats. Methods: The experiments were performed ...

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Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax.

Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax.

... T C GT A A among -179 to -159 -35 to -55 A cCC C G G T T AA to 48 -48 to -68 -39 to -59 68 the TREs, CREs, and the 5'-CCCACAGTCCCCCGTGACGTCACCCGGGAGCCCGGGGGATCC-3' 3'-CCTAGGGGGTGTCAGGGGG[r] ...

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Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1

Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1

... 58). Since vIRF1 expression considerably reduced the Ser15 phosphorylation of p53, we examined whether vIRF1 expres- sion affected the activation of ATM kinase activity upon treat- ment with etoposide, a DNA ...

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The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

... Real-time (RT) PCR was used to detect expression of PKG1 mRNA in the dorsal horn of the spinal cord in each group (Fig. 3). Compared with the CCI group, ex- pression of PKG1 mRNA in the HBO group was signifi- cantly ...

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