muscle derived- stem cell
Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration
... In order to test whether the age of donor hMDSCs affects their osteogenic potential and bone regenerative capacity, we isolated three gender-matched pairs of young and old hMDSCs. We transduced each population of the ...
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Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration
... skeletal muscle, regenerative medi- cine represents a promising therapeutic strategy, which has involved the use of seed cells with myogenic origin such as satellite cell (SC), myoblast and ...
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Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair
... heart muscle grafts has so far only been attempted in animal models, with encouraging results ...the cell sheet technology is presently under clinical investigation in Japan with skeletal myoblasts as a ...
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Substrate and strain alter the muscle-derived mesenchymal stem cell secretome to promote myogenesis
... other cell types, and topog- raphy [17]. In skeletal muscle, the extracellular environ- ment consists of a variety of matrix proteins, including but not limited to collagen type 1 (COL) and laminin (LAM) ...
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Electrospinning of poly (ester amide) fibres for mesenchymal progenitor cell differentiation
... adult stem cells is a promising alternative to primary vascular smooth muscle cells (VSMC) and endothelial cells (ECs) due to their increased proliferative capacity compared to differentiated primary cells, ...
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Pluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy
... smooth muscle rhabdomyosarcoma origin [7] displayed relatively high expression of both early neural differentiation markers: (PAX6, Musashi1, & βIII-tubulin ...skeletal muscle tumors ...Rhabmyosarcoma- ...
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Skeletal Muscle Stem Cells from Animals I. Basic Cell Biology
... skeletal muscle structures are finalized during the fetal stage of de- ...are derived from pools of embryonic stem cells (see ...these stem cells from myogenesis to adipogenesis may increase ...
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Effects of sildenafil and/or muscle derived stem cells on myocardial infarction
... fibrosis, cell loss, and the resulting dysfunction in tissues of various rat organs and that implantation of skeletal muscle-derived stem cells (MDSC) exerts some of these ...and stem ...
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Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration
... progeroid stem cells can be rescued, at least in part, by exogenous factors secreted by the WT stem ...of stem and progenitor cells in response to environmental ...the muscle atrophy and ...
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Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
... tenogenic differentiation of progenitor cells, tendon regen- eration and functional recovery in relevant in vivo models. This is attributable to the specific hierarchical order of the tendon unit. Indeed, such scaffold ...
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Differences in the cargos and functions of exosomes derived from six cardiac cell types: a systematic review
... smooth muscle cell-derived exosomes (HAoSMC-EXOs) also play roles in cardiovascular dys- function and atherosclerosis by modulating autophagy of ECs via the PTEN/Akt signaling pathway ...smooth ...
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A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors
... needed. Stem cells may provide the basis for a new approach. Emerging stem cell therapy of brain tumors The lack of efficacy for conventional treatments of malig- nant brain tumors can be readily ...
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Human adipose derived mesenchymal stem cells attenuate collagen antibody induced autoimmune arthritis by inducing expression of FCGIIB receptors
... Adipose-derived MSCs (ASCs) and BM-MSCs can both differentiate toward multiple mesodermal tissue types, in- cluding bone, cartilage, and adipose tissue, are both im- munosuppressive, and have similar surface ...
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Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma
... Figure 4. Effect of isotretinoin (INN) on apoptosis and cell proliferation in the tumor model. (a) Fluorescence images showing apoptotic cells by TUNEL assay (red) in untreated controls and treated tumor models ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... Cardiac toxicity remains a major cause of restriction or withdrawal of drugs from the market [1]. Between 1990 and 2001, eight non-cardiovascular drugs were with- drawn at an estimated cost of $12 billion due to drug- ...
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Advancing stem cell therapy from bench to bedside: lessons from drug therapies
... that stem cell ther- apy would surpass the conventional synthetic drug ther- apy, which is the only treatment modality currently available for many ...can stem cells themselves can be considered as a ...
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Experimental neurotransplantation treatment for hereditary cerebellar ataxias
... Taken together, it has been shown in mouse models of hereditary cerebellar degeneration that it is possible to suppress the degenerative process and thereby prevent or delay irreversible neuropathological changes and to ...
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Fast Adipogenesis Tracking System (FATS)—a robust, high-throughput, automation-ready adipogenesis quantification technique
... depend on particular commercial software (capable of taking existing images), not require lipid droplets overlaid with nu- clei (instead taking their proximity to nuclei into account), and can deal with other staining ...
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Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas
... different cell surface markers, such as desmin, vascular endothelial (VE)-cadherin, α-smooth muscle actin (α-SMA), nestin, and nerval/glial antigen (NG2) (Table 1) ...multiple cell lines, such as ...
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Therapeutic applications of adipose cell-free derivatives: a review
... Adipose-derived stem cell; ADSC-CM: Adipose- derived stem cell-conditioned medium; ADSC-Exo: Adipose-derived stem cell exosomes; ALS: Amyotrophic lateral ...
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