myeloid differentiation primary response gene
Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells
... that myeloid differentiation primary response gene 88 (MyD88) lies upstream of BLT2 in LPS-potentiated invasiveness and that this ‘MyD88-BLT2’ cascade mediates activation of NF-κB and ...
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Kaposi's Sarcoma-Associated Herpesvirus Reduces Cellular Myeloid Differentiation Primary-Response Gene 88 (MyD88) Expression via Modulation of Its RNA
... immunity. Myeloid differentiation primary response gene 88 (MyD88) is an essential adaptor molecule for IL-1 as well as most Toll-like receptor ...
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MiR 21: an environmental driver of malignant melanoma?
... translocation gene 2; CAF: cancer- associated fibroblast; EMT: epithelial-mesenchymal transition; FAS: FAS cell surface death receptor; FASLG: FAS ligand; FBXO11: F-box only protein 11; FOXO1: forkhead box O1; ...
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Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
... the phenotype is more pronounced in some muscle types or in pure muscle cells. Remarkably, we also found a negative association between muscle-derived IL32 levels and whole body insulin sensitivity in humans in vivo. Our ...
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Bisphosphonates and adipogenesis: Evidence for alendronate inhibition of adipocyte differentiation in 3T3 L1 preadipocytes through a vitamin D receptor mediated effect
... treatment. An increase in VDR mRNA expression of 3T3-L1 cells was observed with both ALN and VD3. On the contrary, 3T3-F442A cells, which are in a more advanced adipogenic differentiation stage compared to 3T3-L1, ...
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Evidence that HIV 1 restriction factor SAMHD1 facilitates differentiation of myeloid THP 1 cells
... the measurement of electrical impedance of the cell population by micro-electronic biosensors in a plastic well over time [20]. Two parameters reflect fast and strong adhesion: a high slope of the line < impedance = a ...
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Skin innate immune system in psoriasis: friend or foe?
... a primary defect in the terminal dif- ferentiation response to injury by KCs that fail to produce a normal stratum corneum and, therefore, do not create a protective physiological barrier? Alterna- tively, ...
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Marked Suppression of T Cells by a Benzothiophene Derivative in Patients with Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis
... and 2.7%, respectively. CI-959-A at 1 mM suppressed the dif- ferentiation of both types of DCs by more than 50%. There was a statistical difference in the DC differentiation rate be- tween CI-959-A and CI-959. ...
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Impact of DNMT3A Gene Mutation on Response of Acute Myeloid Leukemia Patients to Induction Therapy
... mutation on the overall outcome for AML patients, but could be a predictive factor for response to Idarubicin, and thus, could have a direct influence on the way AML patients should be managed [18]. Ribeiro and ...
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The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
... MiR-10b is upregulated in NPM1-mutated AML A previous study documented that a unique miRNA signature was associated with NPM1-mutated AML and miR-10b expression in clearly differentiated NPMc+ vs. NPMc- cases [16]. To ...
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Regulation of smooth muscle-specific transcription by serum response factor and formin homology domain containing protein 1
... terminal differentiation but retain a capacity to undergo significant and reversible changes in phenotype in response to environmental ...in response to mitogenic ...
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Deubiquitinating enzymes as oncotargets
... Gene expression is controlled by transcription factors that directly bind to DNA. Transcription factors act in complexes with other proteins and DUBs can affect their activity by deubiquitinating transcription ...
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Myeloid-Derived Suppressor Cells Regulate Natural Killer Cell Response to Adenovirus-Mediated Gene Transfer
... C57BL/6 mice were treated intravenously at days ⫺ 1, 0, and ⫹ 1 with 100 g of anti-Gr-1 antibody or an isotype control Ab or intraperitoneally at days 0 and ⫹2 with 200 g of gemcitabine and infected with 2 ⫻ 10 9 PFU ...
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Acute Megakaryoblastic Leukaemia: Experience of Diagnostics at Three Clinical Centres
... fused gene RBM15-MKL1 exerts a modulating effect on chromatin organisation, NOx-induced differentiation and extracellular signaling ...chronic myeloid leukaemia blast crisis can be observed 13 ...
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A Study on the Occurrence and Subtyping of Acute Leukemias Based on Morphology and Cytochemistry.
... Hoelzer D et al in their analysis concluded that there are some serious pitfalls of the morphology in T-ALL, clearly indicating the need for immunological analysis of the leukaemic cells. However, morphology remains an ...
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GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies
... GRAF gene is located at chromo- some 5q31 and its protein is ubiquitously expressed in various tissues ...GRAF gene were found in some cases with AML or myelodys- plastic syndrome (MDS) with a deletion 5q ...
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A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells
... biochemical response is still largely ...osteocyte primary cilium plays an important mechanosensory role in bone turnover ...osteocyte primary cilium is required to sense spatiotemporal flow and is ...
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Investigation of the molecular pathogenesis of Kostmann's syndrome
... Many of the cytokine receptors have more than one membrane-bound isoform in addition to their soluble isoform. These also arise from the use of alternative splice sites with either insertion or deletion of genetic ...
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Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment
... Rag1/2 gene antisilencer 71-75 kb 5’ of the Rag2 gene (Yannoutsos et ...Notch1 gene (Gomezdel Arco et ...to gene regulation (Figure S4A, ...
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Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation
... demonstrate that EGR-1 mRNA levels are increased in part by transcriptional activation of this gene in M-CSF-stimulated monocytes. The results also demonstrate that both EGR-1 and EGR-2 mRNA levels are regulated ...
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