N-Acetylneuraminic acid
Binding to Gangliosides Containing N-Acetylneuraminic Acid Is Sufficient To Mediate the Immunomodulatory Properties of the Nontoxic Mucosal Adjuvant LT-IIb(T13I)
... sialic acid moieties of ganglio- sides are heterogeneous and include N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc), among many others ...
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Exogenous supplement of N-acetylneuraminic acid improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice
... NANA: N-acetylneuraminic acid; PPAR α : Proliferator-activated receptor α ; RCT: Reverse cholesterol transport; SR-BI: Scavenger receptor B type ...
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Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs
... are N-glycolylneuraminic acid (Neu5Gc) and N- acetylneuraminic acid ...monophosphate-N-acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene, ...
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Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N Acetylneuraminic Acid as a Host Adaptation
... sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glyco- lipid lipooligosaccharide ...Sialic acid expressed on LOS is critical in NTHi biofilm formation and immune ...
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Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase Pseudogene and Implications of Haplotype Diversity for Human Evolution
... The human CMP-N-acetylneuraminic acid hydroxylase gene (CMAH) suffered deletion of an exon that encodes an active center for the enzyme 3.2 million years ago (MYA). We analyzed a 7.3-kb intronic ...
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N Acetylneuraminic Acid (NANA) Stimulates in situ cyclic AMP Production in Tentacles of Sea Anemone (Aiptasia pallida): Possible Role in Chemosensitization of Nematocyst Discharge
... of N-acetylneuraminic acid (NANA) on nematocyst discharge, adhesive force and tentacle cAMP ..., N=3 experiments; n=18 ..., N=3; ..., N=2; n=20) and endoderm ( 䊉 , ...
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Structural Insights into the Recovery of Aldolase Activity in N -Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy
... Chemical modification has been used to introduce the unnatu- ral amino acid g-thialysine in place of the catalytically impor- tant Lys165 in the enzyme N-acetylneuraminic acid lyase (NAL). The ...
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Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis.
... sialic acid bound in the active site of subunits A, B, and D, while in subunit C, discontinuous electron density reveals the positions of enzyme-bound pyruvate and ...
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High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats
... lic acid was purchased from Santa Cruz Biotechnol- ogy (Santa Cruz, CA, ...sialic acid (Neu5Ac) were pur- chased from Pfizer (New York, NY, USA) and Carbo- synth Limited (Compton, Berkshire, UK), ...
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Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Skin Lightening Activities: Identification of N Acetylneuraminic Acid as Active Ingredient
... citric acid are the most abundant soluble chemicals and therefore considered to be the targeted ...citric acid in EBN after standard processing ...citric acid dropped by 90% after the processing ...
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Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli
... The functional role of induction of the sialic acid-spe- cific uptake systems has been demonstrated in many ways under many conditions. The classical approaches include growth experiments and liposome-swelling ...
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Structural Basis of Rotavirus Strain Preference toward N-Acetyl- or N-Glycolylneuraminic Acid-Containing Receptors
... N-Acetylneuraminic acid (Neu5Ac) and N-glycolyl- neuraminic acid (Neu5Gc) are the most common neuraminic acids in nature, being ubiquitously expressed on the surface of most mammalian ...
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SIALIC ACID TRANSPORT IN E. COLI: ROLE OF OUTER MEMBRANE PORIN NANC
... Sialic acid is a nutrient of bacteria important in host-pathogen ...sialic acid from outer membrane to periplasmic space of Escherichia coli is not ...known. N-acetylneuraminic acid ...
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Structural and functional characterization of the <em>Helicobacter pylori </em>cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism
... pseudaminic acid biosynthesis protein F; NmCNS, Neisseria meningitidis CMP-5-N-acetylneuraminic acid synthetase; MmCNS, Mus musculus CMP-5-N-acetylneuraminic acid ...
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Cytidine monophosphate <em>N</em>-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells
... Notes: (A) In Neu5Ac biosynthesis glucose is first converted to UDP-GlcNAc by a series of enzymes in the cytosol. In two steps, GNE then converts UDP-GlcNAc to ManNAc to Mannac-6-P. nans adds PeP to Mannac-6-P to ...
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Plasmodium gallinaceum ookinetes adhere specifically to the midgut epithelium of Aedes aegypti by interaction with a carbohydrate ligand
... of N-acetylneuraminic acid (NANA) or the related sugars keto- deoxynononic acid (KDN) and keto-deoxyoctonic acid (KDO); NANA could also be detected, with minimal loss of material, when ...
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Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide.
... coli K92 antigen, an N-acetylneuraminic acid homopolymer containing alternating a2--8 and a2-*9 linkages, occurred, but the enzyme failed to release a2-*3-, a2-6-, or a2-*9-linked sialic[r] ...
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Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS
... arachidonic acid (AA, 20:4 n-6), eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), the precursors of anti-inflammatory bioactive lipids lipoxin A4 ...
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Synthesis and Characterization of Some Hot Brand Reactive Dyes and Their Application on Various Fibers
... H- acid, K-acid, J-acid, T-acid, Metanilic acid, Gamma acid, N-methyl-J-acid, Tobias acid, Bronner’s acid, Chicago acid, Laurent’s acid, ...
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Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice
... -tetraacetic acid; Ca 2+ : current-voltage (I/V); calcium; cDNA: complementary deoxyribonucleic acid; CNNM1: Cyclin and CBS domain divalent metal cation transport mediator 1; CNNM2: Cyclin and CBS domain ...
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