N-acetylneuraminic acid (sialic acid)
Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N Acetylneuraminic Acid as a Host Adaptation
... utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glyco- lipid lipooligosaccharide ...(LOS). Sialic acid expressed on LOS is critical in NTHi ...
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Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs
... The sialic acids that are commonly found in mammalian cells are N-glycolylneuraminic acid (Neu5Gc) and N- acetylneuraminic acid ...monophosphate-N-acetylneuraminic ...
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Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli
... The functional role of induction of the sialic acid-spe- cific uptake systems has been demonstrated in many ways under many conditions. The classical approaches include growth experiments and ...
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High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats
... lic acid was purchased from Santa Cruz Biotechnol- ogy (Santa Cruz, CA, ...and sialic acid (Neu5Ac) were pur- chased from Pfizer (New York, NY, USA) and Carbo- synth Limited (Compton, Berkshire, UK), ...
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Specificity and Affinity of Sialic Acid Binding by the Rhesus Rotavirus VP8* Core
... Rotavirus causes approximately 600,000 childhood deaths through dehydrating diarrhea annually (43) and is also an important veterinary pathogen. Understanding early events in cell entry by rotavirus could aid in the ...
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1. Study on sialic acid as biomarker of cancer
... serum sialic acid (LASA) was measured by using the methods of Katopodis ...phosphotungstic acid was mixed by ...acetate: n- butanol was ...of N-acetylneuraminic acid and ...
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SIALIC ACID TRANSPORT IN E. COLI: ROLE OF OUTER MEMBRANE PORIN NANC
... Sialic acid is a nutrient of bacteria important in host-pathogen ...of sialic acid from outer membrane to periplasmic space of Escherichia coli is not ...known. ...
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Neurotropism of Enterovirus D68 Isolates Is Independent of Sialic Acid and Is Not a Recently Acquired Phenotype
... that sialic acid may only initiate the first step of the entry process, attachment to the cell surface, and is not involved in conformational changes related to uncoating ...
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Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function
... endogenous sialic acid occurs in the cytosol, starting from UDP-N-acetyl glu- cosamine ...to N-acetylneuraminic acid (Neu5Ac) by N-acetylneuraminic acid ...
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A Study of Lipid- and Protein- Bound Sialic Acids for the Diagnosis of Bladder Cancer and Their Relationships with the Severity of Malignancy
... (7). Sialic acid (N-acetylneuraminic acid) is a nine-carbon α-keto acid commonly found at the ends of carbohydrate chains of glycoproteins and glycolipids ...the sialic ...
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Cytidine monophosphate <em>N</em>-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells
... Results: N-acetylneuraminic acid (Neu5Ac), the predominant sialic acid derivative in mam- malian cells, which forms the terminal sugar on mucinous cell surface glycoproteins, was the ...
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Plasmodium gallinaceum ookinetes adhere specifically to the midgut epithelium of Aedes aegypti by interaction with a carbohydrate ligand
... contain sialic-acid-like sugars. Furthermore, free N-acetylneuraminic acid competed with the ookinetes in binding aasays, while other monosaccharides had no ...contain sialic ...
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Structural and functional characterization of the <em>Helicobacter pylori </em>cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism
... pseudaminic acid biosynthesis protein F; NmCNS, Neisseria meningitidis CMP-5-N-acetylneuraminic acid synthetase; MmCNS, Mus musculus CMP-5-N-acetylneuraminic acid ...
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Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide.
... coli K92 antigen, an N-acetylneuraminic acid homopolymer containing alternating a2--8 and a2-*9 linkages, occurred, but the enzyme failed to release a2-*3-, a2-6-, or a2-*9-linked sialic[r] ...
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Expression of 9 O and 7,9 O Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses
... ABSTRACT Sialic acids (Sia) are widely displayed on the surfaces of cells and tis- sues. Sia come in a variety of chemically modified forms, including those with acetyl modifications at the C-7, C-8, and C-9 ...
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Studies on the defect underlying the lysosomal storage of sialic acid in Salla disease Lysosomal accumulation of sialic acid formed from N acetyl mannosamine or derived from low density lipoprotein in cultured mutant fibroblasts
... mutant fibroblasts, 40% of the radioactivity remained in lysosomes, whereas no labeled free sialic acid was detected in lysosomes from normal fibroblasts. We conclude that in Salla disease, fibroblast ...
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Sialic Acid of Human Blood Platelets
... The release of sialic acid from platelets by influenza lyzed platelet remnants were spun down 21,000 X g for 2 hours, the supernatant fluid neutralized with 0.1 M virus, neuraminidase, a[r] ...
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Initial Interaction of Rotavirus Strains with N-Acetylneuraminic (Sialic) Acid Residues on the Cell Surface Correlates with VP4 Genotype, Not Species of Origin
... amino acid sequences of SA-dependent and SA-indepen- dent animal and human rotavirus strains, the amino acid se- quences of the VP8* cleavage products of VP4 were aligned by using the PILEUP program, and ...
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A Preliminary Investigation into the Mediating Role of Positive Affect in the Development of Posttraumatic Stress Disorder among African American Female Sexual Assault Survivors
... are sialic acid analogues that have spacers attached to the 2 position via a thiol linkage, in contrast, SC5-8 are analogues derived from Zanamivir® and attached to the spacer at the 7 ...
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Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus
... Fasting blood was collected in bottles containing diso- dium ethylene diamine tetraacetate Dehydrate (EDTA) and the plasma was separated immediately by centrifuga- tion at 3000 rpm for 15 minutes at 4 0 C. Total ...
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