Nanoparticles for gene delivery:
Cross-linked polyethylenimine–tripolyphosphate nanoparticles for gene delivery
... PEI-TPP nanoparticles in terms of size, zeta potential, and Fourier- transform infrared (FTIR) spectra, and assessed their transfection efficiency, cytotoxicity, and ability to resist deoxyribonuclease (DNase) I ...
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Biocompatible Polymer–Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery
... as gene delivery systems is one of the most important directions in both polymer science and ...uniform nanoparticles with a slightly negative zeta potential were ...hybrid-based gene ...
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CHITOSAN BASED INTRATUMORAL INJECTABLE NANOPARTICLES FOR GENE DELIVERY TO PANCREATIC CANCER CELLS
... pEGFP nanoparticles are prepared by polyelectrolyte ...i.t. gene delivery via fluorescence microscopy, flow cytometry and ...This delivery system involves simple preparation procedures and can ...
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Polysaccharide-modified nanoparticles with intelligent CD44 receptor targeting ability for gene delivery
... Dovepress Polysaccharide-modified nanoparticles for gene delivery at δ 3.6 ppm for CH 2 of ethylene glycol. The PLGA-PEG copo- lymer was further conjugated with HA or CD at a feed molar ratio of 1:1. ...
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In Vivo Bio distribution and Efficient Tumor Targeting of Gelatin/Silica Nanoparticles for Gene Delivery
... non-viral gene delivery system is an attractive alternative to cancer ...non-viral gene delivery is hampered by transfection efficiency and tumor targeting, which can be individually overcome ...
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Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells
... Viral gene delivery vectors, such as retroviruses, adeno- viruses, and adeno-associated viruses, are extensively used for gene delivery and show superior transfection ...nonviral gene ...
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Targeted cationic poly(D,L-lactic-co-glycolic acid) nanoparticles for gene delivery to cultured cells
... cationic nanoparticles with DNA encapsulated (NP1) or adsorbed to their surface (NP2) are able to efficiently transfect HepG2 cells in vitro in the presence of 60% FBS; however, no gene expression was ...
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Ternary nanoparticles composed of cationic solid lipid nanoparticles, protamine, and DNA for gene delivery
... SLN/protamine/DNA gene delivery system was designed to improve transfection ...lipid nanoparticles were prepared using an aqueous solvent diffusion ...on gene transfection efficiency mediated ...
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Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications
... distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of ...
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Fabrication of Positively Charged Fluorescent Polymer Nanoparticles for Cell Imaging and Gene Delivery
... for gene delivery. To achieve an efficient gene transfection process, several strategies have been developed based on chemical or physical stimulations such as pH and temperature ...functionalized ...
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The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy
... dexamethasone, gene delivery, brain-derived neurotrophic factor Introduction An inner ear delivery system for drugs (or genes) has been developed using viral or non-viral ...viral delivery ...
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Assessment of DNA Damage During Gene Delivery in Freshwater Prawn by Chitosan Reduced Gold Nanoparticles
... to nanoparticles concentrations (10 µg/L, 20 µg/L) of CRGNPs by immersion treatment for a period of 36 ...nano-gene delivery in aquatic invertebrates and development of transgenics employing less ...
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In vivo targeted gene delivery to peripheral neurons mediated by neurotropic poly(ethylene imine)-based nanoparticles
... low gene transfer ...vivo gene therapy are the specific targeting of the desired cell population as a way to avoid off-target delivery and increase the transgene expres- sion in the target tissue, ...
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Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery
... peptide-DNA nanoparticles (RNPs) encapsulated within a PLA-PEG ...Composite nanoparticles based on these copolymers exhibited a range of acceptable DNA release rates over a 6-week in vitro ...prolonged ...
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Local gene delivery via endovascular stents coated with dodecylated chitosan–plasmid DNA nanoparticles
... Keywords: gene delivery, endovascular stent, chitosan, gene nanoparticles Introduction Percutaneous transluminal coronary angioplasty (PTCA) and stent implantation are the major treatment ...
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Reprogramming fibroblasts to pluripotency using arginine-terminated polyamidoamine nanoparticles based non-viral gene delivery system
... Abbreviations: HE, hematoxylin-eosin; iPSC, induced pluripotent stem cell; NOD-SCID, nonobese diabetic-severe combined immunodeficient. would facilitate more effective interactions with negatively charged DNA by the ...
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Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery
... for gene silencing showed that it was able to silence GFP at lower concentrations of siRNA as well as maintain good cell viability compared to nucleofection and lipofection ...
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Feasibility study of magnetic effects on silver nanoparticles for drug and gene delivery in Cyprinus carpio
... silver nanoparticles under its acute toxicity produced by seaweed Sargassum angustifolium that is produced by biological methods were ...bio nanoparticles of 102 nm with spherical ...Magnetic ...
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Cellular Endocytosis and Gene Delivery
... Ultimately, each vector type is associ- ated with its own set of strengths and caveats when used to manipulate a given endocytic pathway and deliver cargo to target cells. Although viral vec- tors are extremely efficient ...
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A novel type of self-assembled nanoparticles as targeted gene carriers: an application for plasmid DNA and antimicroRNA oligonucleotide delivery
... Keywords: gene delivery, hyaluronic acid, polyethyleneimine, anti-miR-221, PLGA Introduction Nucleic acid-based therapeutics could play a significant role in the treatment of a variety of diseases in the ...
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