NER, nucleotide excision repair
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the ...genomic NER, the XPC protein complex ...
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The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition
... in NER-deficient L1 in- sertions fall within the size range of genomic copy number variations (Eichler ...in NER, such as XP patients, are likely to be subject to higher levels of DNA damage caused by L1 ...
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Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... Rhp7p and Rhp16p form a protein complex and function in GG-NER [12]. Surprisingly, rhp7 and rhp16 genes are located very close together in a head-to-head orientation [12]. The expression of these genes in response ...
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Nucleotide excision repair in aging & cancer
... essentiële NER‐factoren defect is kan dit leiden tot zeldzame ziektes zoals Xeroderma pigmentosum (XP), Trichothiodystrophy (TTD) of Cockayne syndroom ...essentiële NER‐factoren (XPA en XPC) ...door ...
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Interactions and function of nucleotide excision repair complexes
... een NER p ro te in ...purified NER proteins from ...e excision repairosom ...1995). NER factors in this com plex w ere id en tified bo th by im m u n o b lo ttin g a n d b y fu n ctio n al com ...
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<em>ERCC1 </em>and <em>XRCC1 </em>as biomarkers for lung and head and neck cancer
... for nucleotide excision repair (NeR) of bulky chemical DNA adducts like cisplatin intrastrand crosslinks, the repair of double-strand breaks that cannot be directly ligated back ...
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<em>ERCC1</em> rs3212986 A/C polymorphism is not associated with chemotherapy treatment outcomes in gastric cancer patients: evidence from 11 publications in Chinese populations
... DNA repair systems play an important role in repairing the damage to DNA induced by endogenous and/or exogenous factors such as therapeutic ...agents. Nucleotide excision repair (NER) ...
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The XPC-hHR23b complex and nucleotide excision repair of DNA
... the repair of a substrate containing a single specific platinum adduct (Figure ...the NER process in repairing these lesions and thus, possibly decreasing the efficiency of chem otherapy ...
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Nucleotide excision repair deficiency in melanoma in response to UVA
... reduced NER function in melanoma has important clinical ...coupled repair (TCR) genes CSA and CSB in Cockayne’s ...mismatch repair (MMR) pathway result in hereditary non-polyposis colorectal cancer ...
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Original Article Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population
... Larynx cancer is an important entity of cancer, which accounts for 30%-40% of all malignant head and neck tumors [1, 2]. It is estimated that the there were 138,102 new cases with laryngeal cancer and 73,261 deaths from ...
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Base flipping in nucleotide excision repair
... several repair mechanisms have evolved to avoid these ...mechanisms, nucleotide excision repair (NER) 2 is characterized by the unique feature that it is able to recognize and ...
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Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes
... of NER-deficient strains between substrates containing (A) four recombination products (Chen and Jinks-Robertson base-base mismatches, (B) four 1-nt loops, (C) four 4-nt ...
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Nucleotide excision repair is a predictor of early relapse in pediatric acute lymphoblastic leukemia
... whether NER gene expression was altered at the level of the whole path- ...upregulated NER genes was com- pared to a theoretical “no change” prediction of 10 genes upregulated and 10 genes ...individual ...
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The Mechanism of Nucleotide Excision Repair-Mediated UV-Induced Mutagenesis in Nonproliferating Cells
... The DNA damage checkpoint response is activated by NER- generated single-strand gaps (Giannattasio et al. 2004, 2010). In brief, RPA-coated single-strand DNA (ssDNA) recruits the Mec1-Ddc2 kinase complex, while ...
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DNA damage repair in ovarian cancer: unlocking the heterogeneity
... Nucleotide excision repair (NER) is a highly conserved and versatile pathway used to remove ‘bulky lesions’ caused by UV light and carcinogens such as benzopyr- ene, which would otherwise ...
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Mechanisms of interstrand DNA crosslink repair and human disorders
... ICL repair is exceptionally challenging because an ICL lesion affects both DNA ...various excision repair pathways, including nucleotide excision repair (NER), base ...
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Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to Squamous Cell Carcinomas of the Head and Neck (SCCHN) and Breast cancer in the north Indian population
... the Nucleotide excision repair (NER) pathway, a major DNA repair pathway that removes photoproducts from UV radiation and bulky adducts from a huge number of chemicals, cross-links and ...
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Nucleotide excision repair : a multi-step mechanism required to maintain genome integrity
... multiple repair pathways and various checkpoint signal transduction and effectors systems (hoeijmakers, ...dNa repair. several different dNa repair pathways have been identified which are activated ...
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Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing
... Nucleotide excision repair (NER) is a multistep DNA repair process in which a broad spectrum of DNA lesions are re- moved in two stages - one acting genome-wide (GG-NER) and the ...
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Role of Repair Enzymes - Damage Control of DNA From Ageing pans
... GG- NER or, presumably, CSB and CSA in TC-NER recruit the multi-subunit (ten protein complex) and the multi-functional transcription factor TFIIH to the site of ...∼30 nucleotide bubble flanking the ...
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