neuronal cytoplasmic inclusions
Neuronal cytoplasmic inclusions in tau, TDP-43, and FUS molecular subtypes of frontotemporal lobar degeneration share similar spatial patterns
... ‘signature’ neuronal cytoplasmic inclusions (NCI) characteristic of these ...(TDP-43)-immunoreactive inclusions (FTLD-TDP), and (3) FTLD with ‘fused in sarcoma’ (FUS)-immunoreactive inclu- ...
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Spatial patterns of phosphorylation-dependent TDP-43-immunoreactive neuronal cytoplasmic inclusions (NCI) in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
... pTDP-43-immunoreactive neuronal cytoplasmic inclusions (NCI) in vari- ous brain regions lobe (MFG = Middle frontal gyrus, ITG = Inferior temporal gyrus, PHG = Parahippocampal gyrus, CA1/2 = Sectors ...
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Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease
... and neuronal cytoplasmic inclusions in the cere- bral cortex and hippocampus that are immunoreactive for ubiquitin (ub-ir) but negative for tau, synuclein and inter- mediate filament proteins ...
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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
... ubiquitin-positive neuronal cytoplasmic inclusions (NCI) in a portion of ALS cases led to the re- examination of other neurological diseases with NCI of unknown ...glial inclusions, in sev- ...
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FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases
... plasmic inclusions and thread-like (phospho)-TDP-43 immunoreactivity was seen in the white ...of neuronal cytoplasmic inclusions in the frontal cortex and hippocampus Case 1 and 2 were ...
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Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration
... the neuronal cytoplasmic inclusions (NCI) seen in DG granule cells, characteristic of patients with Semantic Dementia (SD) and type C TDP-43 pathology, but did not detect TDP-43 or tau ...
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Different molecular pathologies result in similar spatial patterns of cellular inclusions in neurodegenerative disease:a comparative study of eight disorders
... the neuronal cytoplasmic inclusions (NCI) characteristic of these ...(FUS)-immunoreactive inclusions in neuronal intermediate filament inclusion disease (NIFID), and the transactive ...
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Quantitative pathological changes in the cerebellum of multiple system atrophy
... selective neuronal loss, gliosis, and myelin pathology [25], the ‘signature’ pathological lesion being the glial cytoplasmic inclu sion (GCI) found mainly in oligodendrocytes ...tive neuronal ...
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Combined Diffusion Tensor Imaging and Apparent Transverse Relaxation Rate Differentiate Parkinson Disease and Atypical Parkinsonism
... PD is marked by the loss of dopamine neurons in the substantia nigra SN.3 MSA is characterized neuropathologically by glial and neuronal cytoplasmic inclusions in many basal ganglia and [r] ...
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Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS.
... in neuronal cytoplasmic inclusions in the spinal cord anterior horn was also present in the index case (figure ...had cytoplasmic inclusions positive for both optineurin and ubiquitin; ...
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Fibrinogen storage disease without hypofibrinogenemia associated with estrogen therapy
... The inclusions observed in our patient were large, hyaline bodies occupying the entire cytoplasm, resulting in a ground-glass ...II inclusions. Neither the characteristics of Type I inclusions, such ...
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GnRH agonist versus GnRH antagonist in assisted reproduction cycles: oocyte morphology
... GnRH receptors are expressed in the human ovary, but the action of GnRH analogues on oocyte morphology and quality remains controversial. In the present study, no sig- nificant difference was observed between the ...
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Amyotrophic lateral sclerosis: update and new developments
... families, incomplete penetrance was noted in females, presumably due to X-inactivation. The encoded ubiquilin-2 protein (Figure 1) normally performs effector functions in the ubiquitin proteasome pathway by tethering ...
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Pregnancy in multiple system atrophy: a case report
... glial cytoplasmic inclusions in brain stem nuclei, basal ganglia and white matter tracts, consistent with a neuropathological diagnosis of multiple system ...
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A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
... upper edge of the granule cell layer. The data were then expressed per 250 x 50m sample field so that they were directly comparable with those from the other brain regions. The NCI [34,35, GI [36-41], NII [42] and DN ...
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Dysregulation of the ALS associated gene TDP 43 leads to neuronal death and degeneration in mice
... of neuronal populations including upper motor neurons, a motor phenotype, and the vari- able presence of TDP-43 aggregates ...43 inclusions in our tTA/TDP-ΔNLS and tTA/TDP-WT mice make it unlikely that ...
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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
... differentially affected by macroautophagy deficiency. Purkinje neurons deficient in Atg7 display axonal swel- lings and are rapidly lost [51]. TH-positive midbrain DA neurons display axonal dystrophy and degeneration, ...
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Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities
... to neuronal dysfunction and ultimately cell death (recently reviewed in ...pathological inclusions observed among the ...glial cytoplasmic inclusions has been shown to have a different ...
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Morphological Identification of Cell Death in Dorsal Root Ganglion Neurons Following Peripheral Nerve injury and repair in adult rat
... in neuronal cell bodies decreased in direct epineurial suture repair but no in autograft repair ...sensory neuronal loss to 50% [16] or lesser than 50% (present ...
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SDH-deficient renal cell carcinoma – clinical, pathologic and genetic correlates: a case report
... Conclusions: Without the identification of SDHB deficiency, this patient ’ s personal and familial predisposition to PC, PGL, GIST and metachronous RCCs may have gone undetected despite his RCC diagnosis. When faced with ...
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