Neuropilin 1
Original Article MiR-152 regulates metastases of non-small cell lung cancer cells by targeting neuropilin-1
... and neuropilin-1 was up-regulated in the NSCLC ...and neuropilin-1 were inversely ...of neuropilin-1 mRNA to inhibit its ...inhibited neuropilin-1 mediated cell ...
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Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues
... malignancy. Neuropilin-1 (NRP1) as an isoform-specific receptor for vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) in endothelial cells has been demonstrated to be expressed in ...
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Neuropilin-1 is a receptor for extracellular miRNA and AGO2/ miRNA complexes and mediates the internalization of miRNAs that modulate cell function
... examined neuropilin-1 (NRP1), in view of its properties as a receptor for many ligands, including growth factors such as vascular endothelial growth factor (VEGF), and efficiency at mediating ligand ...
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Neuropilin 1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk
... as diabetic retinopathy, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease. The molecular dynamics governing immune cell recruitment to sites of injury and disease in the CNS during sterile ...
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The significance of neuropilin-1 for the diagnosis of hepatocellular carcinoma in Egyptian patients
... and neuropilin-1 were statistically significantly higher in patients groups than control group and also statistically significantly higher in group II than in group ...
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Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry
... Various viruses use several molecules to interact with target cells. Therefore, it is possible that more than one molecule contributes to HTLV-1 entry. Given the particular mode of transmission of HTLV-1, ...
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<p>Neuropilin-1 is associated with the prognosis of cervical cancer in Henan Chinese population</p>
... soluble Neuropilin-1 (NRP-1) has been reported to be a valuable diagnostic biomarker in patients with cervical intraepithelial neoplasia (CIN) and early cervical ...
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Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection
... ABSTRACT Neuropilin-1 (Nrp1) plays important roles in axonal guidance in neurons and in the growth of new blood ...by neuropilin-1 in the immune ...that neuropilin-1 is expressed ...
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Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
... for 1 hour with horseradish peroxidase-labelled IgG (Santa Cruz biotechnology, ...anti-Neuropilin 1 (Abcam ab81321); anti-GAPDH V-18 (Santa Cruz sc-20357), ...
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MicroRNA-19b-3p suppresses gastric cancer development by negatively regulating neuropilin-1
... Methods: Immunohistochemistry (IHC) and western blot assay were performed to determine the protein expression levels of neuropilin-1 (NRP1) and mRNA levels were confirmed by quantitative RT-PCR (qRT-PCR) in ...
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Original Article The prognostic value of neuropilin-1 in various cancers: a meta-analysis
... between neuropilin-1 (NRP-1) and the progression of many malignant cancers, and the level of NRP-1 expression can be considered as a potential prognostic biomarker for ...
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Bone marrow cells recruited through the neuropilin 1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice
... the neuropilin-1 (NP-1) receptor and that they are essential for the maturation of the activated endothelium and the formation of arteries in ...
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MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1
... for 1 h at 25 °C and then incubated overnight at 4 °C with the following primary antibodies: anti-Neuropilin 1 (A-12) (NRP1) (Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-phospho- histone ...
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Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin 1 in non small cell lung cancer
... Background: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ...
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Neuropilin-1 drives tumor-specific uptake of chlorotoxin
... Results: Neuropilin-1 (NRP1), an endocytic receptor on tumor and endothelial cells, was identified as a novel Cltx target, and NRP1 binding by Cltx increased drug uptake into ...
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Neuropilin 1 biases dendrite polarization in the retina
... that neuropilin-1 (Nrp1) and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class ...
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The wiring of Grueneberg ganglion axons is dependent on neuropilin 1
... of neuropilin 2 alters the projection map formed by GC-D-expressing neurons in the necklace glomeruli in mice (Walz et ...bulb. Neuropilin 2 plays thus a role in preventing GC-D axons from arborizing too ...
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Neuropilin 1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF β signaling in hepatic stellate cells
... PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain ...
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Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma
... co-receptor, neuropilin-1 (NRP- 1) actively binds TGFβ1, the primary mediator of EndMT and is involved in oncogenic processes like epithelial-to-mesenchymal transition ...
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Peripheral nerve derived VEGF promotes arterial differentiation via neuropilin 1 mediated positive feedback
... transgenes, as well as both ‘floxed’ alleles of the Vegf gene (Gerber et al., 1999), we generated and then inter-crossed Wnt1-Cre; Vegf flox/+ with Isl1-Cre; Vegf flox/+ mice. On average, one in 16 embryos derived from ...
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