nicotinic acetylcholine receptor
Optical studies of nicotinic acetylcholine receptor subtypes in the guinea pig enteric nervous system
... Nicotinic transmission in the enteric nervous system (ENS) is extensive, but the role of individual nicotinic acetylcholine receptor (nAChR) subtypes in the functional connectivity of its ...
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Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury
... Methods: In this study, we determined whether inhibition of inflammatory macrophages by administration of α 4 β 2 nicotinic acetylcholine receptor (nAChR) agonists improves neuropathic p[r] ...
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Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor alpha 8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens
... Target-site resistance is commonly caused by qualitative changes in insecticide target-receptors and few studies have implicated quantitative changes in insecticide targets in resistance. Here we show that resistance to ...
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Actions of vesamicol on an alpha bungarotoxin sensitive neuronal nicotinic acetylcholine receptor
... This study, using electrophysiological and ligand-binding techniques on insect nervous tissue, has shown that (±)-vesamicol and its resolved stereoisomers are all reversible, non-competitive blockers of a central nervous ...
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The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism
... 7 nicotinic acetylcholine receptor; CAP: cholinergic anti-inflammatory pathway;ALI: acute lung injury; TNF-α: tumor necrosis factor-α;IL-1β: interleukin-1β; HMGB1: high mobility group box-1 protein; ...
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Mutation (G275E) of the nicotinic acetylcholine receptor alpha 6 subunit is associated with high levels of resistance to spinosyns in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)
... the nicotinic acetylcholine receptor alpha 6 subunit is associated with high levels of resistance to spinosyns in Tuta absoluta (Meyrick) (Lepidoptera: ...
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Noncovalent Interactions of Silent Agonists Binding to the Nicotinic Acetylcholine Receptor and Investigation into Expanding the Substrate Scope and Improving the Efficiency of Organic Photochemical Protecting Groups
... The brain is composed of a complex network of neurons that communicate via the propagation of electrical impulses or action potentials. An action potential travels the length of the neuron until it reaches a synapse ...
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Expression of the α7 nicotinic acetylcholine receptor in human lung cells
... α7 nicotinic acetylcholine receptor was demonstrated in the SCLC cell line NCI-H82, however no protected band was detected in the normal small airway epithelial cells (Figure ...
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The tethered agonist approach to mapping ion channel proteins: toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor
... The tethered agonist strategy has a distinguished history with the nAChR. In pioneering experiments, tethered agonists were introduced into the nAChR using chemical modification of Cys residues created by reduction of ...
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Lynxl and the β2V287L Mutation Affect the Stoichiometry of the α4β2 Nicotinic Acetylcholine Receptor
... Unwin and colleagues performed electron microscopic reconstruction, at increasing resolution, of the muscle-type nAChR receptor over ~3 decades, using samples derived from the postsynaptic membranes of the Torpedo ...
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A Decoy Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite
... via nicotinic acetylcholine receptors ...as acetylcholine binding proteins (AChBPs), could effectively capture 3FTxs and therefore be developed as a novel class of snake-generic therapeutics for ...
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Nicotinic Acetylcholine Receptor-Mediated Protection of the Rat Heart Exposed to Ischemia Reperfusion
... muscarinic acetylcholine receptors. In contrast, the role of nicotinic receptors, specifically α-7 subtype (α7nAChR), in the myocardium remains unknown, which offers an opportunity to potentially repurpose ...
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Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease
... Neuronal nicotinic AChRs (nAChRs) are implicated in the pathogenesis of diverse neurological dis- orders and in the regulation of small-cell lung carcinoma ...
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No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol related behaviors
... Neuronal nicotinic acetylcho- line receptors have been identified as possible targets, since drugs that act at these receptors show potential as a therapeutic option for alcoholism [3, ...
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Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
... line receptor α 7 (ab24644), anti-PTP1B (phospho S378) [EP1840Y] (ab76239), anti-collagen I (ab34710) and anti- choline acetyltransferase [EPR13024(B)] (ab181023) antibodies were from ABCAM (Cambridge, MA, ...
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Host cell-specific folding of the neuronal nicotinic acetylcholine receptor α7 and α8 subunits
... Mice deficient in the neuronal a l subunit were generated by deleting the last three exons of the a l gene (encoding for the M2 transmembrane domain onwards) (Orr Urtreger et a l, 1997). The deletion leaves the coding ...
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Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor
... Because the nicotine-bound conformation was used as the basis for the computational design calculations, the design generated mutations that would further stabilize the nicotine-bound state. The 57R mutation, a secondary ...
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Integrated treatment for autonomic paraneoplastic syndrome improves performance status in a patient with small lung cell carcinoma: a case report
... ganglionic nicotinic acetylcholine receptor; GAD65: Glutamic acid decarboxylase 65; Hu: Neuronal nuclear antibody type 1; IVIg: Intravenous immunoglobulin; MIBG: 123I-metaiodobenzylguanidine; MRI: ...
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Disruption of Drug Effects (Dopamine, Nicotine, Pilocarpine, κ Opioid) in Planarians by UV Light
... by receptor-binding ...D2 receptor antagonist (–)sulpiride ...selective nicotinic acetylcholine receptor agonist nicotine (1, 3, 5 mM) and the selective mus- carinic ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... α7 nicotinic acetylcholine receptor agonist), EPC-K1 (the vitamin E derivative), mela- tonin, cisplatin and glycyrrhizin attenu- ate warm liver I/R damage partly through inhibition of HMGB1 release ...
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