NLRP3 inflammasome
Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome
... the NLRP3 inflammasome in governing the immunopathology asso- ciated with ...an inflammasome- mediated mechanism of inflammation is strongly ...both NLRP3 and NLRC4 play important protective ...
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The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion
... in NLRP3- or RIG-I-mediated inflammasome activation (1, 22, 50, ...the NLRP3 inflammasome ...triggers NLRP3 inflammasome activa- tion in macrophages and dendritic cells (15), ...
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Original Article ROS-activated NLRP3 inflammasome initiates inflammation in delayed wound healing in diabetic rats
... the NLRP3 inflammasome, re- ...production, NLRP3 inflammasome activation and IL-1β ...and NLRP3 inflammasome activation in diabetic rat ...activating NLRP3-IL-1β pathway ...
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Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in rats
... the Nlrp3, pro-caspase-1 (p45), caspase-1 (p20), and IL-1 β protein levels were increased in the NiONP exposed groups from 3 days to 28 days compared with the vehicle control group (Figure ...that Nlrp3 was ...
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Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice
... of NLRP3 inflammasome activation to suppress ...of NLRP3 immediately increased within the first 6 h, further rose until at day 3 and dropped at day 7 post ...of NLRP3 and active-caspase-1 ...
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Correlation of NLRP3 inflammasome expression in periodontitis tissue with inflammatory response and alveolar bone resorption
... (NLRP3) inflammasome is an inflammatory complex composed of NLRP3, apoptosis-associated speck-like protein containing CARD (ASC) and Caspase-1; the upstream receptor molecule NRLP3 belongs to ...
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The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection
... the NLRP3 pathway in helminth-infected humans using MCC950 may be a rational approach for boosting type 2 immu- nity to helminths, lowering worm burdens and limiting the health problems these infections cause in ...
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Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome
... of NLRP3 and the apoptosis-related speckle-like protein containing a caspase recruitment domain (ASC) which controls the extent of inflam- masome activation and IL-1  ...the NLRP3 inflammasome is ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
... the NLRP3 inflammasome itself, as early as possible in disease progres- sion, may prove more beneficial, blocking not only cytokine release but also pyroptotic cell death and the ensuing tissue destruction; ...
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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
... the NLRP3 inflammasome and subsequent neurovascular damage in ischemic stroke ...and NLRP3 inflammasomes and NOX2/iNOS-dependent ONOO − formation in the devel- opment of ICH-induced brain damage ...
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MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome
... that NLRP3 inflammasome activity was negatively controlled by miR-223, which played a role in inflammatory dis- eases [23, 25, 67, ...of NLRP3, but miR-223 deficiency largely promoted the mRNA and ...
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NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes
... elicit NLRP3 inflammasome-mediated ...of NLRP3, and secretion of IL-1β is closely associated with insulin resistance [29, 125, ...the NLRP3 inflammasome and IL-1β expression in ...
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Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages
... alleviate NLRP3 inflammasome changes in BPD has remained ...study, NLRP3 inflammasome levels in LPS-induced THP-1 macrophages were significantly reduced after pretreatment with ...the ...
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Original Article Activation of NLRP3 inflammasome in the ovaries during the development and treatment of polycystic ovary syndrome
... of NLRP3 inflammasomes in a vari- ety of cardiovascular, metabolic, and renal dis- eases ...of NLRP3 inflammasome, and then lead- ing to the ovarian dysfunction of PCOS, includ- ing cystic follicles, ...
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CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin associated periodic syndromes escapes the restriction
... Introduction: NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune ...activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase ...
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Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
... that NLRP3 is expressed in skeletal muscle and show that ApN downregulates NLRP3 via its anti- inflammatory mediator, ...the NLRP3 inflammasome in a murine model of DMD, we crossed mdx mice ...
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Increased expression of the NLRP3 inflammasome components in patients with Behçet’s disease
... species–NLRP3 inflammasome-dependent pathways in ocular BD ...whether NLRP3 inflammasome expression is increased at the mRNA and protein levels in BD patients with skin ...through NLRP3 ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
... the NLRP3 inflammasome itself, as early as possible in disease progres- sion, may prove more beneficial, blocking not only cytokine release but also pyroptotic cell death and the ensuing tissue destruction; ...
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Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs
... the NLRP3 inflammasome are incapable of se- creting the proinflammatory cytokines IL-1β and IL-18 ...Silica-induced inflammasome activation in non- myeloid cells is emphasized in recent publications ...
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The role of the NLRP3 inflammasome in gout.
... the NLRP3 inflammasome, such as IL-18, must also be ...the NLRP3 inflammasome and it will be important to identify such pathways and understand their interaction with the NLRP3 ...
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