NLRP3 inflammasomes
Original Article Paeoniflorin down-regulates the expression of NLRP1 and NLRP3 inflammasomes in rat hippocampal slices after oxygen-glucose deprivation
... and NLRP3 inflammasomes app- ear to play a notable role in the ischemic cas- cade involving the inflammatory response ...and NLRP3 inflammasomes, thereby protecting against the OGD-induced ...
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The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis
... for NLRP3 inflammasome acti- vation are also potential ...of NLRP3 inflammasomes, clearance of damaged mito- chondria by autophagy (mitophagy) can inhibit the activation of NLRP3 ...
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Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection
... of NLRP3 inflammasomes in HSCs are due to stimulation of Schistosoma ...mediating NLRP3 inflammasome activation, we performed a series of experiments in primary cultures of ...of NLRP3 ...
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Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes
... the NLRP3 inflammasome is more ...induce NLRP3 inflammasome activa- ...the NLRP3 inflammasome by ...of NLRP3 with ASC was limited to 4 h ...some NLRP3 and ASC associate with each other ...
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Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells
... of inflammasomes in periodontal inflammatory reactions especially those related to mechanical stimulations has not been ...and NLRP3) inflammasomes and induced the release of IL-1β and pyroptosis via ...
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Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells
... of NLRP3 siRNA on Staphylococcus aureus RN6390-stimulated pro-IL-1β expression and mature IL- 1β ...nM NLRP3 siRNA or 100 nM sc-siRNA prior to co-culture for 4 hours with ...
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Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications
... of NLRP3, ASC and pro-caspase-1, the activation of caspase-1, and the maturation of IL-1β in mouse ...of NLRP3 inflammasome components in hypothalamic paraventricular nucleus, and thus delayed the ...
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HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma
... and NLRP3 inflammasomes and processing IL-1β maturation ...canonical NLRP3-inflammasome activation, induced the processing of IL-1β, and resulted retinal injury and RGC death ...
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Original Article Inhibition of ER stress by 4-PBA protects MCT-induced pulmonary arterial hypertension via reducing NLRP3 inflammasome activation
... Abstract: NLRP3 inflammasome activation and endoplasmic-reticulum (ER) stress contribute to the pathogenesis and development of pulmonary arterial hypertension ...induced NLRP3 inflammasome activation in ...
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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
... the NLRP3 inflammasome and subsequent neurovascular damage in ischemic stroke ...and NLRP3 inflammasomes and NOX2/iNOS-dependent ONOO − formation in the devel- opment of ICH-induced brain damage ...
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Inflammasomes: Pandora’s box for sepsis
... of NLRP3 inflammasomes during sepsis in macrophages, causing their death, release of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to ...
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Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation
... of Nlrp3 inflammasomes [33, ...of Nlrp3 inflammasome (Figure ...of Nlrp3 inflammasome ...palmitate-enhanced Nlrp3 inflammasome activity leads to impairment of endothelial barrier, ...
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Predictable chronic mild stress promotes recovery from LPS-induced depression
... of NLRP3 inflammasome components (NLRP3, ASC, and Caspase-1), and interleukin 1 beta (IL-1 β ) ...inhibit NLRP3 inflammasome overactivation and oxidative ...
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Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis
... of inflammasomes by uric acid leads to tissue destruction, inflammation and fibrosis, and that these symptoms can be relieved by the inhibition of IL-1 signaling in the mouse model of lung emphysema ...
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MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome
... including NLRP3 scaffold, regulatory molecule caspase-1 and apoptosis-associated speck-like protein containing a CARD (ASC), has emerged as a crucial regulator of chronic inflammatory disease [28, ...that ...
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Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats
... of NLRP3, PICs, chemokine ligand 2 (CCL2), C-X-C chemokine recep- tor type 3 (CXCR3), vascular cell adhesion molecule 1 (VCAM-1), and neurohormone level in the develop- ment of ...
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The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
... monocytes were washed and lysed with M-PER Mam- malian Protein Extraction Reagent with phosphatase and protease inhibitors (10 μl/ml, Halt™ Protease and Phosphat- ase Inhibitor Cocktail, Thermo Scientific Inc, Rockford, ...
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Inflammasomes and IL 1 biology in the pathogenesis of allograft dysfunction
... inflammasomes, and each is influenced by a unique pattern-recognition receptor response. Two signals are typically involved in the inflammasome pathways. Signal one involves recognition of pathogen-associated ...
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Current progress of the inflammasomes in aortic aneurysm and aortic dissection
... produce MMP-9 [30,31] . In vitro study by Wu et al. indicated that MMP-9 could be directly activated by NLRP3 inflammasome in thoracic aortic SMCs. Co-immunoprecipitation analysis observed MMP-9 binding to ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
... described and found to inhibit both NLRP3 and AIM2 inflammasome induced IL-1 β processing, by preventing ASC oligomerization. ASC oligomerization is essential for both NLRP3 and AIM2 inflammasome formation. ...
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