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Non-clear cell renal cell carcinoma

Recent advances in the systemic management of non-clear cell renal cell carcinoma: a review article

Recent advances in the systemic management of non-clear cell renal cell carcinoma: a review article

... Though non-clear cell renal cell carcinoma (nccRCC) is not as common as clear cell renal cell carcinoma (ccRcc) in incidence yet it demands ...

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Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

... treating clear-cell ...T cell infiltrates at baseline, day 8 of cycle 2 (biopsy), and day 2 of cycle 1 (serum) ...T cell infiltrates by 70% (CD3+) and 88% ...

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Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma

Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma

... confirmed non-clear cell RCC, presence of metastatic disease, at least one dose of nivolumab mono- therapy administered and available clinical and imaging data prior to initiation of ...

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Human Endogenous Retroviruses in Clear Cell Renal Cell Carcinoma: Biological Functions and Clinical Values

<p>Human Endogenous Retroviruses in Clear Cell Renal Cell Carcinoma: Biological Functions and Clinical Values</p>

... Millions of years ago, retroviruses invaded and integrated into the cells of human hosts, and the resulting genomic components are known as human endogenous retroviruses (HERVs), which are vertically inherited by ...

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Metabolic features of clear cell renal cell carcinoma: mechanisms and clinical implications

Metabolic features of clear cell renal cell carcinoma: mechanisms and clinical implications

... The pentose phosphate pathway (PPP) generates reducing equivalents in the form of nicotinamide adenine dinucleo- tide phosphate (NADPH) and ribose-5-phosphate (R5P) (Fig. 2). Both of these molecules are used by cancerous ...

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Identification of novel long non-coding RNAs in clear cell renal cell carcinoma

Identification of novel long non-coding RNAs in clear cell renal cell carcinoma

... In order to confirm aberrant lncRNA expression, we de- termined the expression of 13 lncRNAs in an independent validation cohort of ccRCC (n = 55) and normal (n = 52) renal tissue samples. The selection of ...

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Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma

Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma

... RCC: renal cell carcinoma; ccRCC: clear cell renal cell carcinoma; mRCC: meta- static renal cell carcinoma; VHL: von Hippel–Lindau; HIFs: ...

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TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients&rsquo; survival

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients&rsquo; survival

... P < 0.0001) from paired normal tissues (Figure 3B). In addi- tion, we found the significant difference of TRIM2 mRNA expression in ccRCC subgroups, including T stage, N stage, M stage, G stage, TNM stage, living ...

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Alteration of ASIC1 expression in clear cell renal cell carcinoma

Alteration of ASIC1 expression in clear cell renal cell carcinoma

... whose original pathological specimens were available for Western blot and quantitative polymerase chain reaction (qPCR). Paired CCRCC and adjacent non-tumor tissues were obtained, snap-frozen in liquid nitrogen, ...

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ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma

ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma

... versus non-smokers was different in tumor in comparison to normal ...versus non-smokers in normal tissue as well as the fold change of smokers versus non-smokers tumor ...

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Original Article The effects of LOXL2 in clear cell renal cell carcinoma: a

Original Article The effects of LOXL2 in clear cell renal cell carcinoma: a

... adjacent non-cancerous tissues (ANTs) were obtained from ccRCC patients af- ter radical nephrectomy at Sichuan University West China Hospital in China from June 2013 to August ...

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Original Article Expressions of miR-193b and miR-338-3p in renal clear-cell carcinoma cells and their effects on biological function

Original Article Expressions of miR-193b and miR-338-3p in renal clear-cell carcinoma cells and their effects on biological function

... in renal clear-cell carcinoma ...in renal clear-cell ...glioblastoma, non-small cell lung cancer, and other tumor cells [14, ...tumor cell ...

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NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498

NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498

... 5% non-fat dry milk for 1 hour at room temperature, membranes were probed with an appropriate antibody overnight at 4°C followed by a horseradish peroxidase (HRP)-linked goat anti-mouse or anti-rabbit antibodies ...

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Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma

Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma

... non-invasive technique (urine, blood), or ii) by a simple and sensitive method easily transposable to clinical practices. The presence of high amounts of mRNA in tumors of patients that relapsed toward a M1 ...

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Review Article Clear cell papillary renal cell carcinoma: a review

Review Article Clear cell papillary renal cell carcinoma: a review

... all renal tumors occurring in young adults ...(sporadic, non familial setting), non-cystic end-stage renal disease (ESRD) and acquired cystic disease (ACD) [1, 6-9, ...other renal ...

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Genetic mutations associated with metastatic clear cell renal cell carcinoma

Genetic mutations associated with metastatic clear cell renal cell carcinoma

... Frozen tumor samples from patients were fixed in 4% PFA for 24 hours, followed by paraffin block embedding and sectioning. Formalin fixed sections are cut at 4 uM and baked at 60 degree for at least 1 hour before ...

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A four-gene signature predicts survival in clear-cell renal-cell carcinoma

A four-gene signature predicts survival in clear-cell renal-cell carcinoma

... of non-canonical nucleotides, which may cause DNA damage and cancer, indicating a significant role of ITPA in preventing base analog-induced apoptosis, DNA damage and mutagenesis in human cells ...cancer ...

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Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

... tumour cell type in patients with non-metastatic ...than clear cell and papillary in a single ...in clear cell than in papillary ...RCC cell type have yielded conflicting ...

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Identification of clear cell renal cell carcinoma and oncocytoma using a three gene promoter methylation panel

Identification of clear cell renal cell carcinoma and oncocytoma using a three gene promoter methylation panel

... cases, renal mass biopsy is mandatory, for adequate risk stratification, which requires accurate diagnosis [4, ...in renal mass biopsy, it is non-diagnostic in approximately 15% of patients, more ...

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Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

... : renal cell carcinoma; ccRCC : clear cell renal cell carcinoma; mRCC : metastatic renal cell carcinoma; pRCC : papillary renal ...

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