Non-structural protein 1 (NS1)
Tick-borne Encephalitis Virus Vaccines Contain Non-structural Protein 1 (NS1) Antigen and May Elicit NS1-Specific Antibody Responses in Vaccinated Individuals
... viral non-structural protein 1 ...of NS1 in FSME-IMMUN was confirmed by immunization of mice with six doses of this vaccine, which led to a robust anti-NS1 antibody ...response. ...
13
Dengue virus Non-Structural Protein 1: Roles in Replication and Immunity.
... with NS1 does not lead to enhanced T cell proliferation by DV1 infected ...with NS1/HNS1 and infected with DV1 for 24h upregulated CD86 to similar levels (Chapter 3, Figure ...the NS1 pretreated ...
166
Bluetongue virus non structural protein 1 is a positive regulator of viral protein synthesis
... which NS1 increases the expression of the BTV genes, including itself, creating a positive feedback loop of NS1 expression which increases the rate of synthesis of all the viral proteins, as has been found ...
11
The Effects of P320Sc Mutation in West Nile Non-structural Protein 1 (NS1) and the Generation of Aptamers to Detect Dengue NS1 in the Context of Infection.
... 23 There are several tests which may be used for early detection of flavivirus infection. These include RT-PCR based amplification of viral genome from patient blood, ELISA-based detection of viral NS1 ...
159
Ovine and murine T cell epitopes from the non-structural protein 1 (NS1) of bluetongue virus serotype 8 (BTV-8) are shared among viral serotypes
... However, NS1(403) peptide which was a predicted binder using SYFPEITHI and Pro- Pred-I algorithms but not by the NetMHC algorithm showed weak affinity for D b in RMA-S cell binding ...binding NS1 (403) ...
12
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate
... DENV NS1 is a 48-kDa glycoprotein that is highly con- served among all flaviviruses ...[12]. NS1 is essential for viral replication with an unknown mechanism that possibly in- volves interactions with NS4A ...
11
Mutation of the elongin C binding domain of human respiratory syncytial virus non structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus
... [8,9]. NS1 and NS2 of both bovine and human RSV are type I Interferon (IFN a/b) antagonists and target type I IFN induction and signaling ...of NS1, more so than NS2, from human recombinant (r) RSV ...
12
Apoptosis, cytokine and chemokine induction by non structural 1 (NS1) proteins encoded by different influenza subtypes
... chemotactic protein-1; CCL-3/MIP-1 α : Chemokine (C-C motif) ligand 3/Macrophage inflammatory protein-1 α ; CCL-4/MIP-1 β : Chemokine (C-C motif) ligand 3/Macrophage inflammatory ...
9
Flavivirus NS1: a multifaceted enigmatic viral protein
... complex 1; DCNS1, dengue C ’ terminal amino acid; DENV, dengue virus; DHF, dengue hemorrhagic fever; DJNS1, dengue N ’ terminal amino acid; DSS, dengue shock syndrome; ECM, extracellular matrix; f(H), glycoprotein ...
10
EVALUATION OF NS1 ANTIGEN CAPTURE ELISA AND IgM ANTIBODY CAPTURE ELISA IN ACUTE CASES OF DENGUE IN RURAL POPULATION IN A TERTIARY CARE TEACHING HOSPITAL IN WESTERN UTTAR PRADESH INDIA
... virus non-structural protein 1 (NS1), and IgM antibody capture are available with different sensitivities and specificities observed in various ...i.e. non-structural ...
5
Delayed and highly specific antibody response to nonstructural protein 1 (NS1) revealed during natural human ZIKV infection by NS1 based capture ELISA
... The non-structural protein 1(NS1) of flavivirus can be released from infected cell to the blood or expressed on the cell ...surface. NS1 is also highly antigenic and contrib- ...
7
Usefulness of dengue ns1 antigen as an early marker of dengue virus infection in a tertiary care hospital
... drawbacks. Non- Structural Protein 1(NS1) is a highly conserved glycoprotein that is essential for the viability of dengue virus (DENV) and circulates uniformly in all serotypes of ...
6
Development and characterization of serotype specific monoclonal antibodies against the dengue virus 4 (DENV 4) non structural protein (NS1)
... a 1% low melting point agarose (LMPA) (Invitrogen), and the appropriate band was excised, and purified using a QIAGEN Gel Extraction Kit (QIAGEN, Gaithersburg, MD, USA) and double-restriction enzyme digested with ...
12
The Influenza A Virus Protein NS1 Displays Structural Polymorphism
... of NS1 is low, NS1 may exist as a monomer ...Monomeric NS1 may be favored when NS1 undergoes structural changes, for instance, when in complex to PI3K (13) ...of NS1 increases, ...
10
Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family
... (EV71). Non-enveloped enterovirus is spherical in shape, with a diameter ranging from 28 nm to 30 ...capsid protein fraction of the virus, whereas P2 and P3 comprise the non-structural pro- ...
9
Marozin, Sabrina (2006): Interferon Escape of Respiratory Syncytial Virus: Functional Analysis of Nonstructural Proteins NS1 and NS2. Dissertation, LMU München: Tierärztliche Fakultät
... (capsid protein V3), rotavirus (NSP3) and influenzavirus (NS1) (Chang ...E6 protein of human papillomavirus type 16 (HPV-16) binds IRF3 and therefore inhibits its activity (Ronco ...
123
Effects of Influenza A Virus NS1 Protein on Protein Expression: the NS1 Protein Enhances Translation and Is Not Required for Shutoff of Host Protein Synthesis
... virus NS1 protein, a virus-encoded alpha/beta interferon (IFN- ␣ /  ) antagonist, appears to be a key regulator of protein expression in infected ...that NS1 protein expression results ...
7
Translational Inhibition and Increased Interferon Induction in Cells Infected with C Protein-Deficient Measles Virus
... C protein-deficient MV has been reported to grow well in Vero, B95a, and human neuroblastoma SK-N-MC cells (14, 38, 40, 45, ...C protein of MV is likely to be able to modulate the IFN and PKR systems, since ...
7
Protein interaction studies on the rotavirus non structural protein NSP1
... The eleven segments of dsRNA that comprise the rota virus genome and the proteins encoded by each gene are shown for the UKtc strain of bovine rotavirus.. The structural proteins which m[r] ...
325
Influenza C virus NS1 protein counteracts RIG I mediated IFN signalling
... of NS1, this IFN-b promoter activation was decreased, whereat NS1 from strain C/ JHB/1/66 exhibited stronger inhibitory ...truncated NS1 proteins from both strains (NS1-50-239-JJ and ...
6