Notch1 pathway
Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression
... activated Notch1 pathway promotes FAK expression and the phosphorylated state of Tyr397 residue in FAK (referred to hereafter as pFAK Y397), a pivotal event in the FAK-mediated ...
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<p>PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway</p>
... cells, which was the consequence of decreased apoptosis rate. Moreover, we demonstrated that PRKD2 expression was positively correlated with the activity of Notch1 pathway. Notch1, NICD and HES1 ...
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Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer
... factors Notch1, ZEB1, and ZEB2, which had the capacities to directly repress the expression of epithelial markers E-cadherin and β -catenin but increase mesenchymal markers N-cadherin and vimentin, a characterized ...
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Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4
... years, Notch1 has been found to be overex- pressed in GICs, and the Notch pathway plays a vital role in the stem maintenance of glioma cells [7, ...Notch pathway requires that the receptor bind to ...
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MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway
... the Notch1 pathway, facilitating down- stream gene transcription and thereby promoting G1 to S cell cycle phase transition as well as proliferation ...
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Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
... clear. Notch1 signalling has been shown to play an oncogenic role in the majority of hematological malig- nancies including ...Further, Notch1 is related to resistance to chemotherapy, a major cause of ...
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Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway
... whether Notch1 signaling was activated in CD44v6+ LCSCs, we measured the expression of the key components in Notch1 signaling in CD44v6+ and CD44v6- ...of Notch1, NICD (cleaved Notch1), and ...
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Activated Notch1 Inhibits p53-Induced Apoptosis and Sustains Transformation by Human Papillomavirus Type 16 E6 and E7 Oncogenes through a PI3K-PKB/Akt-Dependent Pathway
... human Notch1 was originally cloned from a chromo- somal rearrangement generated in a human T-cell acute lym- phoblastic leukemia cell line ...of Notch1 protein ...
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Original Article Jagged-1 attenuates LPS-induced apoptosis and ROS in rat intestinal epithelial cells
... Notch pathway in affecting the pathogenesis of UC and regulating intestinal epithelial cell proliferation and ...Jagged-1, Notch1, Hes1, and OLFM4 in colon tissues were detected by real-time quantitative ...
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NON-CODING NOTCH1 MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA; THEIR CLINICAL IMPACT IN THE UK CLL4 TRIAL
... The genomic and clinical characteristics of NOTCH1 non-coding and coding mutations in the LRF CLL4 trial. (A) The distribution of mutations in NOTCH1[r] ...
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The p53 transcriptional pathway is preserved in ATM mutated and NOTCH1 mutated chronic lymphocytic leukemias
... p53 pathway, ATM, BAX, CDKN1A, MDM2, NOTCH1, NOTCH2, TNFRSF10A, TNFRSF10B, and TP53 itself (Supplemental Table 1) was performed using Ion Torrent chemistry (Life Technologies, Foster City, ...
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Original Article Fluoxetine alleviates cerebral ischemic injury by regulation of Notch1 signaling pathway in rats
... of Notch1 signaling pathway in adult ischemic ...signal pathway inhibitor) group (Group ...evaluate NOTCH1 with immunohistochemistry in the ...reduced Notch1 protein level, fluoxetine ...
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Role of the Notch1 Tad in Embryonic Development and Hematopoiesis
... the Notch1 TAD influenced the binding of the Notch1 trimolecular complex to DNA targets, we performed oligo-immunoprecipitation experiments using a biotinylated oligonucleotide containing the RBPJ binding ...
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Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway
... and Notch1 signaling pathways [33–39] Activa- tion of ERK was almost present in all T-ALL samples, and activation of MEK/ERK was an independent negative prognostic indicator for T-ALL patients [33, ...signaling ...
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Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch
... the Notch1 signaling ...that Notch1 signaling was significantly suppressed by BMSCs at 24 h and 72 h post-SAH, which was confirmed by measuring protein and mRNA levels of Notch1, NICD, RBP-Jκ, and ...
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Luteolin suppresses gastric cancer progression by reversing epithelial mesenchymal transition via suppression of the Notch signaling pathway
... The remodeling of the cytoskeleton upon luteolin treat- ment indicated that luteolin may regulate this process by inhibition of EMT in GC cells. We observed that the epi- thelial biomarker E-cadherin was increased and ...
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Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma
... MiR-34a, a classic tumor suppressor, plays an important role in the initiation, progression and even therapy of many tumors [20]. MiR-34a was found to regulate many key genes that control the cell cycle, cellular ...
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Original Article KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro
... tissues-enriched notch1 and KRT6B implicated in RCC ...of notch1 and KRT6 in the tumor tissues and corresponding nontumourous specimens from RCC patients, and densitometric quantification for western ...
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Original Article Notch1 promotes tumor growth in colon cancer by targeting Fascin1
... of Notch1 expression is associated with tumor ...dysregulated Notch1 expression induces colon cancer growth remains ...of Notch1 and Fascin1 were found to be higher in human colon cancer tissues than ...
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The NOTCH1-HEY1 pathway regulates self-renewal and epithelial-mesenchymal transition of salivary adenoid cystic carcinoma cells
... and then incubated with primary antibodies against Caspase-3 (1:300, Cell Signaling, USA), Caspase-9 (1:500 dilution, Abcam, UK), Ki-67 (1:500 dilution, Abcam, UK), NOTCH1 (1:400 dilution, Sigma, USA) and HEY1 ...
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