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nuclear hormone receptors

Nuclear hormone receptors in podocytes

Nuclear hormone receptors in podocytes

... Nuclear hormone receptors (NRs) belong to family of sequence specific and ligand activated transcription fac- tors that both positively and negatively regulate gene ex- pression and are involved in ...

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New role for nuclear hormone receptors and coactivators in regulation of BRCA1 mediated DNA repair in breast cancer cell lines

New role for nuclear hormone receptors and coactivators in regulation of BRCA1 mediated DNA repair in breast cancer cell lines

... important nuclear hormone receptors expressed by breast cancer cells are those for estrogen and retinoic acid ...Estrogen receptors (ER) and retin- oic acid receptors (RAR) are members ...

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Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell Culture

Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell Culture

... HNF4:RXR␣-PPAR␣ nuclear hormone receptor recognition sequence ...the nuclear hormone receptor binding site of the variant HBV genome are indicated above the wild-type HBV ...the nuclear ...

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Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier

Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier

... In this study, we have shown that activators of the PPAR a (oleic acid, linoleic acid, or clofibrate) and of the FXR (farne- sol or JH III) accelerate barrier development, as evidenced by decreased transepidermal water ...

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The role of nuclear receptors in the kidney in obesity and metabolic syndrome

The role of nuclear receptors in the kidney in obesity and metabolic syndrome

... are nuclear hormone receptors that stimulate tran- scription of specific genes by binding to specific DNA ...another nuclear receptor, the RXR, to form a complex that interacts with specific ...

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Hormonal regulation of xenopus nuclear receptors and their target genes

Hormonal regulation of xenopus nuclear receptors and their target genes

... transcription underlying metamorphosis. In most mammalian tissues or cells there are about 2,000 to 10,000 molecules of TR proteins (see Section 3.2.2; Oppenheimer et al., 1972; Oppenheimer et at., 1974). Since the ...

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Brain nuclear receptors and body weight regulation

Brain nuclear receptors and body weight regulation

... The estrogen-related receptors (ERRs) ERRα, ERRβ, and ERRγ are orphan nuclear hormone receptors with no known ligands. While ERRs can bind and regulate gene transcription via the same estrogen ...

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Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells

Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells

... melanocyte-stimulating hormone (MSH); the cells were highly responsive to treatment with MSH, which increased the rate of melanin production 25-fold and tyrosinase activity 6-fold within 4 ...MSH receptors ...

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Nuclear receptors: emerging drug targets for parasitic diseases

Nuclear receptors: emerging drug targets for parasitic diseases

... Nuclear receptors are promising drug targets for treating parasitic ...modulating nuclear receptor sig- naling may provide exciting and novel therapeutic ...Although nuclear receptors ...

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Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana

Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana

... We propose that riboswitches function as receptors for signaling molecules, including the classic plant hormone cytokinin. As with many known receptor signaling path- ways, the end result would be altered ...

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Cardiac nuclear receptors: architects of mitochondrial structure and function

Cardiac nuclear receptors: architects of mitochondrial structure and function

... Nuclear receptors in the heart play a fundamental role in the con- trol of energy metabolism and ...cardiac nuclear receptors as a metabolic modulatory strategy aimed at the relatively early ...

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Immunohistochemical localization of sex hormone receptors in two Raillietina tapeworms.

Immunohistochemical localization of sex hormone receptors in two Raillietina tapeworms.

... their receptors function throughout the entire developmental stages of the reproductive systems of both tapeworms, including the initial stage, spermary development, ovary development, and ...

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Regulation of rat CYP2B1 gene expression: The role of nuclear receptors

Regulation of rat CYP2B1 gene expression: The role of nuclear receptors

... Cytochrom e P450 (GYP) plays a central role in the m etabolism of endogenous and exogenous compounds. This thesis aims to investigate the molecular mechanism which underlies CYP2B1 induction in response to xenobiotics, ...

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Involvement of PPAR nuclear receptors in tissue injury and wound repair

Involvement of PPAR nuclear receptors in tissue injury and wound repair

... transcription factors that sense injury. PPARs are such factors and are activated by lipid mediators produced after wounding. Here we highlight advances in our understanding of PPAR action during tissue repair and ...

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Functional differences between two CRF related diuretic hormone receptors
in Drosophila

Functional differences between two CRF related diuretic hormone receptors in Drosophila

... A receptors dissociate from the arrestin early during receptor internalization, which is evidenced by the continued presence of β -arrestin–GFP at the plasma membrane; and is the pattern exhibited by the DH44-R2 ...

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Concentration of l Thyroxine and l Triiodothyronine Specifically Bound to Nuclear Receptors in Rat Liver and Kidney: QUANTITATIVE EVIDENCE FAVORING A MAJOR ROLE OF T3 IN THYROID HORMONE ACTION

Concentration of l Thyroxine and l Triiodothyronine Specifically Bound to Nuclear Receptors in Rat Liver and Kidney: QUANTITATIVE EVIDENCE FAVORING A MAJOR ROLE OF T3 IN THYROID HORMONE ACTION

... hepatic nuclear receptor sites by three different techniques: (a) specific radioimmunoassay after separation of T 3 and T 4 by preparative paper chromatography; (b) in vivo ...

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Steroid hormone receptors ERα and PR characterised by immunohistochemistry in the mare adrenal gland

Steroid hormone receptors ERα and PR characterised by immunohistochemistry in the mare adrenal gland

... proteins. Although the present study did not attempt to investigate the effect of oestrous cycle stage on receptor staining, it was noted that the mare in oestrus showed the strongest staining intensity and highest ...

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Prognostic role of hormone receptors in endometrial cancer: a systematic review and meta analysis

Prognostic role of hormone receptors in endometrial cancer: a systematic review and meta analysis

... that hormone receptors may have value in predicting survival in patients with endometrial ...three hormone receptors had prognostic value for ...of hormone therapy, and there are many ...

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Protein Kinase A Is Part of a Mechanism That Regulates Nuclear Reimport of the Nuclear tRNA Export Receptors Los1p and Msn5p

Protein Kinase A Is Part of a Mechanism That Regulates Nuclear Reimport of the Nuclear tRNA Export Receptors Los1p and Msn5p

... control nuclear-cytoplasmic tRNA trafficking in response to nutrient ...regulate nuclear tRNA export is also dependent on the type of nutrient ...affects nuclear export of func- tional tRNAs made ...

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Regulation of pituitary gonadotropin releasing hormone receptors by pulsatile gonadotropin releasing hormone injections in male rats  Modulation by testosterone

Regulation of pituitary gonadotropin releasing hormone receptors by pulsatile gonadotropin releasing hormone injections in male rats Modulation by testosterone

... respectively) to suppress endogenous GnRH secretion. Subsequently, intracarotid pulse injections of GnRH (5-250 ng/pulse) or saline in controls were given every 30 min for 48 h, after which gonadotropin responses and ...

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