Nuclear receptor
Optimization of stress response through the nuclear receptor-mediated cortisol signalling network
... To answer this apparent paradox, we further considered the basic biology of PXR. Although originally described as a pro- miscuous nuclear receptor with many endogenous and xenobiotic ligands 26–28 , PXR has ...
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Elevated copper impairs hepatic nuclear receptor function in Wilson’s disease
... bolic nuclear receptor ...measured nuclear receptor target gene mRNA expres- sion and activity in adult hepatic autopsy samples obtained from the National Disease Research Interchange ...
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Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
... both miRNAs resulted in a significant decrease in Myh7 mRNA in WT myotubes and abolished the enhancing effects of PPARβ/δ on slow-twitch gene expression in MCK-PPARβ/δ myotubes (Figure 3A). Second, to assess the ...
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Role Of The Nuclear Receptor Pparγ In Clear Cell Renal And Bladder Urotheial Carcinoma
... The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) has a well-characterized role in the developmental process of adipogenesis and transcriptional regulation of lipid ...X ...
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Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα
... by nuclear receptors, a superfamily of ligand-activated transcription factors, via cis-acting sequences located in the viral ...X receptor alpha (FXR ␣ ) in modulating transcription from the HBV core ...
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SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
... a nuclear localization signal (NLS)-deleted isoform of SRC-3, could function as an adaptor protein for signal transmission from EGFR to FAK ...than nuclear receptor ...
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Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma
... orphan nuclear receptors are known to prevent toxic accumulations of xenobiotics within cells by regulating a broad range of cellular trans- porters ...The nuclear receptor PXR is a mem- ber of this ...
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Identification and Characterization of the Alternatively Spliced Nuclear Receptor Coactivator-6 Isoforms
... The nuclear receptor coactivator-6 (NCOA6, AIB3, PRIP, ASC-2, TRBP, RAP250 or NRC) is a co-activator for nuclear hormone receptors and certain other transcription ...estrogen receptor ...
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A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
... this nuclear receptor mediates the effect of the natural herbal medicine Yin Zhi Huang on this process, and identified a specific active com- pound present in this ...X receptor (FXR) (48) and PXR ...
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MYC dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα
... estrogen receptor–related receptor α (ERRα), a nuclear receptor that cooperates with the transcription factor nuclear factor of activated T cells, c1 (NFATc1) to drive ...
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Role of nuclear receptor-independent pathways in the mechanism of action of peroxisome proliferators
... of nuclear receptor peroxisome proliferator activated receptor alpha (PPARα) ...This receptor is largely responsible for lipid metabolism through transcriptional regulation of fatty acid ...
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Evolution and developmental expression of nuclear receptor genes in the ascidian Herdmania
... 169 nuclear receptor-containing clones derived from the PCR amplification of genomic DNA (55 clones) and cDNA (114 clones), identified eight unique consensus se- ...the nuclear receptor ...
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Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
... orphan nuclear receptor 4A2 (NR4A2/NURR1, nuclear receptor related-1) has recently emerged as a novel transcription factor with regulatory roles in in- flammatory arthritis ...the ...
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NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASE
... The nuclear receptor superfamily describes a related but diverse array of transcription factors, which include nuclear hormone receptors (NHRs) 2 and orphan nuclear ...the receptor is ...
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Regulation of microRNA expression and function by nuclear receptor signaling
... of nuclear receptors contains 48 human members that include classical receptors, adopted orphan receptors and orphan ...estrogen receptor (ER), androgen receptor (AR), pro- gesterone receptor ...
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The Role of the Nuclear Receptor E75 in the Molt Cycle of Daphnia magna and Consequences of its Disruption.
... In the present study we hypothesized that low concentrations of nitric oxide donors would elicit subtle effects which would combine to alter population dynamics of D. magna. Environmental nitrogen oxides can be converted ...
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Impaired SUMOylation of nuclear receptor LRH 1 promotes nonalcoholic fatty liver disease
... other nuclear receptors also contribute to the development of NAFLD by affect- ing steatosis, glucose homeostasis, inflammation, and/or fibrosis in the ...x receptor (PXR) promotes lipogenesis and the ...
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Microcantilever based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor Ligand Interactions
... Figure 2 compares the responses of a PXR functional- ized MC when exposed to three analytes in PBS. This figure illustrates that 1.0 M rifampicin is the most po- tent PXR activator in this group. Our experiments in the ...
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Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization
... human nuclear receptor inter- action protein (NRIP) gene (GenBankTM accession num- bers AY766164 [GenBank] and AAX09330 [GenBank]) and deposited it in the National Center for Biotechnology Information ...
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Critical Roles of Nuclear Receptor Response Elements in Replication of Hepatitis B Virus
... more, although PPAR ␣ is enriched in the liver (28) while PPAR ␥ is not (53), immunoshift assays and Western blot anal- ysis with appropriate antisera failed to detect either PPAR ␣ or PPAR ␥ in nuclear extracts ...
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