nuclear receptor corepressor
Original Article Effect of nuclear receptor corepressor on bone marrow mesenchymal stem cells proliferation
... Abstract: Objective: Bone marrow mesenchymal stem cells (BMSCs) are considered a promising cell source for tissue engineering. Methods to advance the proliferation and anti-apoptotic capacity of mesenchymal stem cells ...
7
Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages
... Gammaherpesviruses are important oncogenic pathogens that transit between lytic and latent life cycles. Silencing the lytic gene expression program enables the establishment of latency and a lifelong chronic infection of ...
9
Progesterone receptors animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer
... Nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptor (SMRT) are both corepressors of numerous transcription factors, including steroid hormone ...the ...
5
Transcriptional activation and dimerisation properties of oestrogen receptor β
... In the absence of ligand, RAR and TR are able to actively repress tra n s c rip tio n (B an iah m ad et al 1992, B aniahm ad et al 1995). This function is present in the LBD of RAR and TR, and is separable from th eir ...
193
Molecular and Structural Insights into Nuclear Hormone Receptor Repression Mediated by the Corepressor NCOR
... [nuclear receptor (NR1H3) and LXRβ (NR1H2) are highly homologous members of the nuclear hormone receptor superfamily that are encoded by two distinct genes (Willy et ...orphan nuclear ...
120
The nuclear corepressor 1 and the thyroid hormone receptor suppress breast tumor lymphangiogenesis
... Vascular Endotelial Growth Factors C and D (VEGF-C and VEGF-D) are crucial regulators of lymphangiogenesis, a main event in the metastatic spread of breast cancer tumors. Although inhibition of lymphangiogenic gene ...
14
NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASE
... biology, nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other ...organism. Nuclear ...
9
Yang, Silei (2012): Rapid neuronal signaling cascades initiated by corticosterone. Dissertation, LMU München: Fakultät für Biologie
... function thus also implicating it causally in depression (Catania et al., 2009; Sotiropoulos et al., 2011). Additionally, recent evidence suggests that c-Abl can modulate the clustering of postsynaptic density (PSD) ...
134
Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... either receptor alone, suggests that RXR a and PPAR transactivate the HBV RARE by forming a functional heterodimeric com- ...other nuclear receptors, such as RAR, HNF-4, thyroid hormone, and/or vitamin D ...
5
Male Pseudohermaphroditism With Partial Androgen Insensitivity
... Studies in skin fibroblasts showed normal androgen receptor affinity and capacity for.. 5a-dihydrotestosterone (DHT), normal nuclear retention of the receptor-DHT complex, and normal con[r] ...
10
Reciprocal Nuclear Shuttling of Two Antagonizing Zn Finger Proteins Modulates Tup Family Corepressor Function To Repress Chromatin Remodeling
... Interestingly, Scr1 rapidly translocates from the nucleus to the cytoplasm in response to glucose starvation (Fig. 4). This localization pattern is reciprocal to that of Rst2 (13). Therefore, such reciprocal ...
10
Activators of peroxisome proliferator activated receptor gamma have depot specific effects on human preadipocyte differentiation
... proliferator–activated receptor (PPAR) g , a nuclear receptor highly expressed in adipo- cytes, induces the differentiation of murine preadipocyte cell ...
6
In vitro binding of L triiodothyronine to receptors in rat liver nuclei Kinectics of binding, extraction properties, and lack of requirement for cytosol proteins
... affect nuclear binding, indicating that active metabolism was not ...the nuclear sites were equilibrated with T3 within 30 min of incubation (one-half maximal binding at 3 min) and that the rate of release ...
12
Transcriptional profiling of spiny lobster metamorphosis reveals three new additions to the nuclear receptor superfamily
... ornatus nuclear receptor gene expression and predicted domain structure Gene expression measured by RLE is plotted for 12 nuclear receptors throughout the 12 developmental stages sampled[r] ...
14
The therapeutic potential of RORγ modulators in the treatment of human disease
... steroid receptor coregulator SRC2 in mice leads to a phenotype similar to von Gierke’s disease (glycogen stor- age disease-1a), a human disorder caused by mutations in the ROR α target gene glucose-6-phosphatase ...
8
Cardiovascular risk and dyslipidemia among persons living with HIV: a review
... : nuclear receptor peroxisome proliferator activator receptor- α ; ABC: abacavir; ACC: American College of Cardiology; ACL: adenosine Triphosphate Citrate Lyase; AHA: American Heart Association; ART: ...
17
Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
... Th e transmembrane or the soluble IL-6 receptor forms a complex with two gp130 molecules after binding IL-6. Th is leads to phosphorylation of Janus protein-tyrosine kinase, which causes the activation of ...
11
AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)
... the nuclear shuttle of AHR induced by 3MC in SkBr3 breast cancer cells is prevented either in the presence of the AHR inhibitor CH223191 or using the GPER an- tagonist G15 ...
18
Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids
... the nuclear receptors RXR (and/or RAR), PPAR, and FXR in the regulation of HBV transcription and replication ...ligand-activated nuclear receptors in HepG2 cells, a definitive characterization of the ...
7
Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25
... in nuclear protein extraction buffer (20 mM HEPES-KOH [pH ...The nuclear extracts were clarified at 13,000 ⫻ g for 2 min, and the supernatants from the nuclear and cytoplasmic fractions were pooled ...
14