nuclear receptor farnesoid X receptor
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
... mature nuclear form of SREBP1 (SREBP1-N) and CIDEA were significantly downregulated in the livers of antibiotic-treated mice on a HFD for 7 weeks (Figure 6, F and ...toll-like receptor 4 (Tlr4), toll-like ...
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Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
... this nuclear receptor are already in advanced clinical trials for treatment of liver dis- eases, 27 and they have also been proposed as potential targets for therapy of several other conditions, including ...
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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells
... Previous studies have demonstrated that hepatic apoM expression could be regulated by certain cytokines and nuclear factors. In our previous study [15], we demon- strated that LXR agonist, TO901317, could ...
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra and extrahepatic cholestasis
... Farnesoid X receptor (FXR) is a bile acid–activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler ...
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Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication
... Earlier studies during the 1970s and 1980s showed that bile acids (CDCA) lowered triglyceride levels in blood through a mechanism not fully understood. Recent studies suggested that triglyceride-lowering effects of bile ...
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Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis
... the nuclear receptor superfamily that binds to and interferes with the positive regulation of gene expression by other nuclear receptors including liver receptor homolog-1 on the target gene ...
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Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D
... The farnesoid X receptor belongs to the nuclear recep- tor family and is expressed in organs like the kidney, liver, adipose tissue and ...
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Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis
... various nuclear receptor agonist assays express either the native receptor or a receptor hybrid in which the native N-terminal DNA binding domain (DBD) is replaced by a yeast Gal4 ...upstream ...
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Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation
... hepatic nuclear factor (HNF) 4α [15], liver X receptors [16], retinoid X receptor (RXR) [17], farnesoid X receptor [18], and per- oxisome proliferator-activated receptors ...
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Farnesoid X receptor represses hepatic human APOA gene expression
... repressor, it has no DNA binding motif (56) but interacts with sev- eral nuclear receptors, such as LRH-1 or HNF4α, thereby interfering with gene transcription. Recently, the SHP/LRH-1/CYP7A1 signal- ing pathway ...
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Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease
... hepatocyte nuclear factor 4-α (HNF4-α) [15, 16] and glucose [17, 18], and downregulation with AMP-activated protein kinase [15, 19], insulin [20–22] and tumor necrosis factor-α (TNF-α) [23, ...
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Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism
... of farnesoid X receptor (FXR) signaling has beneficial effects on the development of obesity ...acid-activated nuclear receptor that regulates the homeostasis of bile acids, lipids, and ...
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Farnesoid X receptor is essential for normal glucose homeostasis
... of PEPCK, PGC-1α, or G-6-Pase expression in response to CA feeding (Figure 6E). On a chow diet, they exhibited modestly elevated serum glucose in both fasted and fed conditions (Fig- ure 6F) without significant changes ...
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Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential
... The nuclear receptor FXR is classically associated with bile acid homeostasis in the body and its target genes impact on the metabolic and transporter-mediated clearance of both bile acids and their ...
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Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma
... Acid Receptor (RAR) associated with RAR response elements in MCF7 breast cancer cells ...D receptor (VDR) could repress Wnt/β-Catenin signaling and decrease 1α, 25(OH) 2 vitamin D3 induced tumorigenesis ...
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Case Report Mammary carcinoma with osteoclast-like giant cells: a case report
... [9]. Receptor activator of nuclear- (RANK), RANK ligand (RANKL), and matrix me- talloproteinase 1 (MMP1) are absent or not overexpressed in the current ...
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Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids
... these nuclear receptors might shift the cellular equilibrium from RXR␣ homodimers capable of activating HBV transcription to RXR ␣ /RAR ␣ or RXR ␣ /PXR heterodimers that are incapable of binding to the ...
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Microcantilever based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor Ligand Interactions
... pregnane X receptor (PXR) is of vital importance in pharmaceutical and exogenous compound metabolism within the ...estrogen receptor (ER-) directly compares the nanomechanical responses of these ...
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Cholesterol Metabolism and Its Regulation by Functional Foods
... releasing nuclear SREBP (nSREBP) in the cytoplasm In contrast, when cells have abundant cholesterol SCAP binds to INSING, stabilizing the protein and allowing the accumulation of a stable complex ...
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Retinoid X Receptor Antagonists
... Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but also are candidate drugs for treatment of various diseases, including diabetes and allergy, although ...
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