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nuclear retinoid X receptors

Retinoid X receptor and retinoic acid response in the marine sponge
Suberites domuncula

Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula

... the nuclear receptor superfamily and, more specificly, to group 2A/2B of these ...oldest nuclear hormone receptor identified to ...the nuclear hormone receptors and their possible existence in ...

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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

... The effect of pharmacological RXR activation on osteoclast differentiation occurs through heterodimerization with LXR, but not with other nuclear receptors expressed in osteoclast pro- genitors, such as ...

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Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation

Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation

... hepatic nuclear factor (HNF) 4α [15], liver X receptors [16], retinoid X receptor (RXR) [17], farnesoid X receptor [18], and per- oxisome proliferator-activated receptors ...

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The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers

The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers

... retinoic X receptor (RXR), activated by 9-cis retinoic acid (9-cis ...II nuclear receptors [23] and explains how fatty acids and retinoids control lipid metabolism ...in retinoid-activated ...

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Original Article Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting

Original Article Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting

... Abstract: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder disease in elderly. It is char- acterized by the formation of amyloid plaques and nerve cells apoptosis in the brain. This study focuses ...

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Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells.

Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells.

... of nuclear receptors, the RA receptors (RARs) and retinoid X receptors (RXRs), which function by activating transcription as heterodimeric or RXR homodimeric complexes from ...

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Cholesterol Metabolism and Its Regulation by Functional Foods

Cholesterol Metabolism and Its Regulation by Functional Foods

... LXRβ nuclear receptors form heterodimers with the retinoid X receptor tivated by a variety of sterols intermediaries and produce an expression of lipogenic genes and high speed of LXR ...

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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

... that nuclear receptors (NRs) are related to the development of ...liver X receptor (LXR) in the lungs was increased in COPD patients, and an LXR agonist exerted anti-inflammatory effects on ...

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Genetic disorders of nuclear receptors

Genetic disorders of nuclear receptors

... Maturity-onset diabetes of the young (MODY), usually defined as diabetes mellitus (diagnosed before age 25 years) with negative islet cell autoantibodies, is most commonly (in about 50% of cas- es) due to mutations in ...

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Nuclear thyroid hormone receptors

Nuclear thyroid hormone receptors

... Isolation ofa cDNA encoding human Rev-ErbAa: transcription from the non-coding DNA strand of a thyroid hormone receptor gene results in a related protein which does not bind thyroid horm[r] ...

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Nuclear receptors in vascular biology

Nuclear receptors in vascular biology

... a nuclear receptor that has a highly promiscuous ligand binding domain, acting as a common drug, hormone, and nutrient sensor that co-ordinates detoxification and elimination pathways in the liver ...

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Nuclear hormone receptors in podocytes

Nuclear hormone receptors in podocytes

... The mechanisms by which aldosterone induces pro- teinuria are likely complex. However, the observation that podocytes express MR suggests a direct role of liganded MR in podocyte injury. In podocytes, aldoster- one ...

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An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

... Bioinformatic analysis of the T. muris genome [15] dem- onstrated that T. muris possesses an RXR-like receptor. Two synthetic retinoids known to modulate the function of mammalian RXR were used to target worm viability ...

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Models of buffering of dosage imbalances in protein complexes

Models of buffering of dosage imbalances in protein complexes

... conformation when it is complexed with binding partners forming an oligomer [18]. This is epitomized by the interac- tions between domains of the cAMP response element binding protein (CREB-binding protein or CBP) and ...

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Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons

Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons

... catenin protein levels in the cortex, we expressed RAR403.GFP or GFP alone in mouse cortices by in utero electroporation, dissected out the electroporated areas and examined levels of active β-catenin by western blot ...

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Bench to bedside review: Ventilation induced renal injury through systemic mediator release   just theory or a causal relationship?

Bench to bedside review: Ventilation induced renal injury through systemic mediator release just theory or a causal relationship?

... interleukin-1 receptor antagonist; iNOS, inducible nitric oxide synthase; I/R, ischemia/reperfusion; KC, keratinocyte chemoattractant; LXR, liver X-receptor/ retinoid X-receptor; MCP, mo[r] ...

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Nuclear Receptors and the Warburg effect in cancer

Nuclear Receptors and the Warburg effect in cancer

... the nuclear receptor ...which nuclear receptors actions are altered during tumori- genic transformation and can serve to enhance the shift to aerobic ...

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Non-steroid anti-inflammatory drugs, prostaglandins, and cancer

Non-steroid anti-inflammatory drugs, prostaglandins, and cancer

... COX-2 has been shown to promote invasive phenotypes through increased expression of matrix metalloproteinases (MMP) 1 and 2 to break down the extracellular matrix and decrease cell-cell adhesion, in human colon cancer ...

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Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids

Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids

... additional nuclear receptors capable of heterodimerizing with RXR ␣ were evaluated for their effects on retinoic acid-activated RXR␣-mediated HBV RNA and DNA syn- thesis ...various nuclear ...

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New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

... The majority of breast cancer tumors express ERα. Drugs that target ERα have been a mainstay of breast cancer treatment for nearly 50 years, yet many of the signaling pathways that underlie such treatments remain incom- ...

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